Structure based design, synthesis, and biological evaluation of imidazole derivatives

• Published in: Bioorganic & medicinal chemistry letters Vol. 36
• Main Authors: Daraji, Drashti G., Rajani, Dhanji P., Rajani, Smita D., Pithawala, Edwin A., Jayanthi, Sivaraman, Patel, Hitesh D.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier 15.03.2021
• Subjects: Chemistry; Chemistry, Medicinal; Chemistry, Organic; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Physical Sciences; Science & Technology; saDHPS; Antiresistant bacterial strains; ADME; Imidazole; Molecular docking

In this study, we have designed and synthesized 2-((5-acetyl-1-(phenyl)-4-methyl-1H-imidazol-2-yl)thio)-N-(4((benzyl)oxy)phenyl) acetamide derivatives. Antimicrobial activities of all the imidazole derivatives have been examined against Gram-positive and Gram-negative bacteria and results showed tha...