Nickel Nanoparticle Catalyzed Mono- and Di-Reductions ofgem-Dibromocyclopropanes Under Mild, Aqueous Micellar Conditions

• Published in: Angewandte Chemie International Edition Vol. 59; no. 40; pp. 17587 - 17593
• Main Authors: Wood, Alex B., Cortes-Clerget, Margery, Kincaid, Joseph R. A., Akkachairin, Bhornrawin, Singhania, Vani, Gallou, Fabrice, Lipshutz, Bruce H.
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 28.09.2020
• Subjects: Chemistry; Chemistry, Multidisciplinary; Physical Sciences; Science & Technology; nickel; nanoparticles; reductions; DEHALOGENATION; CYCLOPROPANATION; CHEMISTRY; COUPLINGS; ADDUCTS; micelles; water chemistry; ALKYL-HALIDES; WATER

Mild mono- and di-hydrodehalogenative reductions of gem-dibromocyclopropanes are described, providing an easy and green approach towards the synthesis of cyclopropanes. The methodology utilizes 0.5-5 mol % TMPhen-nickel as the catalyst, which, when activated with a hydride source such as sodium boro...