Iodide as a Nucleophilic Trigger in Aryne Three-Component Coupling for the Synthesis of 2-lodobenzyl Alcohols
The synthetic potential of KI as the iodide source in aryne three-component coupling has been demonstrated using aldehydes as the third component. This mild and transition-metal free coupling reaction allowed the straightforward synthesis of 2-iodobenzyl alcohols in moderate to good yields with good...
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Published in | Organic letters Vol. 21; no. 11; pp. 4383 - 4387 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
Amer Chemical Soc
07.06.2019
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Subjects | |
Online Access | Get full text |
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Summary: | The synthetic potential of KI as the iodide source in aryne three-component coupling has been demonstrated using aldehydes as the third component. This mild and transition-metal free coupling reaction allowed the straightforward synthesis of 2-iodobenzyl alcohols in moderate to good yields with good functional group compatibility. Moreover, KBr and KCl could be used as the nucleophilic trigger in this aryne multicomponent coupling (MCC) and N-methylisatin and CO2 could be used as the electrophilic third components. |
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ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/acs.orglett.9b01621 |