Design, Synthesis, and invitro Evaluation of Multivalent Drug Linkers for High-Drug-Load Antibody-Drug Conjugates
A series of novel multivalent drug linkers (MDLs) containing cytotoxic agents were synthesized and conjugated to antibodies to yield highly potent antibody-drug conjugates (ADCs) with drug/antibody ratios (DARs) higher than those typically reported in the literature (10 vs. approximate to 4). These...
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Published in | ChemMedChem Vol. 13; no. 8; pp. 790 - 794 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WEINHEIM
Wiley
23.04.2018
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Subjects | |
Online Access | Get full text |
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