Nucleophilic F-18-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors: Advantages and Disadvantages

• Published in: European journal of organic chemistry Vol. 2017; no. 3; pp. 453 - 458
• Main Authors: Petersen, Ida Nymann, Kristensen, Jesper Langgaard, Herth, Matthias Manfred
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 18.01.2017
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; DESIGN; RADIOFLUORINATION; ARENES; F-18-FLUORINATION; FLUORINATION; SALTS; FLUORIDE; POSITRON-EMISSION-TOMOGRAPHY; ARYL HALIDES; Comparative studies; Nucleophilic substitution; Spiro compounds; Ylides; BORYLATION; Isotopic labeling

The field of labeling electron-rich aryl compounds with nucleophilic [F-18] fluoride has recently expanded with radio-fluorination strategies that apply boronic esters or spirocyclic iodonium ylides as precursors. Herein, we present a direct comparison of these strategies by using nine chemically di...