Copper(II)-Catalyzed -Borylation of Acetylenic Esters in Water
A method for the -borylation of alkynoates has been developed. In the presence of bis(pinacolato)diboron and catalytic amounts of both copper(II) and 4-picoline, substituted alkynoates undergo borylation in a regio-, stereo-, and chemoselective fashion. The reaction is performed under mild condition...
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Published in | Synthesis (Stuttgart) Vol. 47; no. 15; pp. 2242 - 2248 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
STUTTGART
Thieme Medical Publishers
01.08.2015
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Subjects | |
Online Access | Get more information |
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Summary: | A method for the -borylation of alkynoates has been developed. In the presence of bis(pinacolato)diboron and catalytic amounts of both copper(II) and 4-picoline, substituted alkynoates undergo borylation in a regio-, stereo-, and chemoselective fashion. The reaction is performed under mild conditions using water as solvent and open to the atmosphere to exclusively afford (Z)--boryl-,-unsaturated esters. |
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ISSN: | 0039-7881 1437-210X |
DOI: | 10.1055/s-0034-1380524 |