Mechanistic Studies of Wacker-Type Intramolecular Aerobic Oxidative Amination of Alkenes Catalyzed by Pd(OAc)(2)/Pyridine

• Published in: Journal of organic chemistry Vol. 76; no. 4; pp. 1031 - 1044
• Main Authors: Ye, Xuan, Liu, Guosheng, Popp, Brian V., Stahl, Shannon S.
• Format: Journal Article
• Language: English
• Published: WASHINGTON Amer Chemical Soc 18.02.2011
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; N-FLUOROBENZENESULFONIMIDE; NITROGEN NUCLEOPHILE; ALCOHOL OXIDATION; SELECTIVE OXIDATION; ORGANIC-CHEMICALS; C-N; PALLADIUM(II)-CATALYZED OXIDATION; SOLVATION MODELS; CIS-AMINOPALLADATION; MOLECULAR-OXYGEN
• ISSN: 0022-3263; 1520-6904
• DOI: 10.1021/jo102338a

Wacker-type oxidative cyclization reactions have been the subject of extensive research for several decades, but few systematic mechanistic studies of these reactions have been reported. The present study features experimental and DFT computational studies of Pd(OAc)(2)/pyridine-catalyzed intramolec...