Design of novel cyclic altered peptide ligands of myelin basic protein MBP(83-99) that modulate immune responses in SJL/J mice

• Published in: Journal of medicinal chemistry Vol. 51; no. 13; pp. 3971 - 3978
• Main Authors: Katsara, Maria, Deraos, George, Tselios, Theodore, Matsoukas, John, Apostolopoulos, Vasso
• Format: Journal Article
• Language: English
• Published: WASHINGTON Amer Chemical Soc 10.07.2008
• Subjects: Chemistry, Medicinal; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Science & Technology; MULTIPLE-SCLEROSIS PATIENTS; EPITOPE; ANALOG; RECOGNITION; AMINO-ACIDS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; INDUCTION; MANNAN; T-CELLS; ANTIGEN

The use of antagonist peptides derived from the myelin sheath constitutes a promising therapeutic approach for multiple sclerosis (MS). Cyclization of peptide analogues is of great interest, since the limited stability of linear peptides restricts their potential as therapeutic agents. Herein, we de...