An environmentally benign system for synthesis of beta-hydroxyl ketones: L-histidine asymmetrically catalyzed direct aldol reactions in aqueous micelle and water-like media

• Published in: Chinese journal of chemistry Vol. 25; no. 3; pp. 356 - 363
• Main Authors: Peng Yi-Yuan, Peng Shu-Jun, Ding Qiu-Ping, Wang Qi, Cheng Jin-Pei
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 01.03.2007
• Subjects: Chemistry; Chemistry, Multidisciplinary; Physical Sciences; Science & Technology; ROUTE; L-PROLINE; ACID; DE-NOVO SYNTHESIS; AMINO; MICHAEL ADDITION; ALPHA-AMINATION; asymmetric synthesis; poly(ethylene glycol); beta-hydroxylketone; ORGANOCATALYTIC CONJUGATE ADDITION; SMALL ORGANIC-MOLECULES; histidine

The first histidine catalyzed direct aldol reactions of ketones with nitrobenzaldehydes in water and in poly(ethylene glycol) (PEG) were reported. It reveals that histidine is a good aldol catalyst for synthesis of beta-hydroxylketones in water and in PEG, giving good to excellent yields of the resp...