Synthesis and biological activity of 4 '-thio-1-xylofuranosyl purine nucleosides

• Published in: Nucleosides, nucleotides & nucleic acids Vol. 24; no. 10-12; pp. 1895 - 1906
• Main Authors: Tiwari, KN, Messini, L, Montgomery, JA, Secrist, JA
• Format: Journal Article
• Language: English
• Published: PHILADELPHIA Taylor & Francis 01.01.2005
• Subjects: Biochemistry & Molecular Biology; Life Sciences & Biomedicine; Science & Technology; 4 '-thionucleosides; nucleosides; T-ARAC; METABOLISM; ANALOGS; DNA; purines; antiviral activity; 4'-THIO-BETA-D-ARABINOFURANOSYLCYTOSINE; OSI-7836; 2-CHLORO-9-(2-DEOXY-2-FLUORO-BETA-D-ARABINOFURANOSYL)ADENINE; DFDC

A series of some new 4'-thio-L-xylofuranosyl nucleosides were prepared and evaluated as potential anticancer agents. A versatile sugar intermediate for direct coupling with the purine moiety is also synthesized by an efficient and high-yielding route. Proof of structure and configuration at all...