Copper-catalyzed synthesis of N-unsubstituted 1,2,3-triazoles from nonactivated terminal alkynes

• Published in: European journal of organic chemistry Vol. 2004; no. 18; pp. 3789 - 3791
• Main Authors: Jin, T, Kamijo, S, Yamamoto, Y
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 13.09.2004
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; TETRAZOLES; PHASE; cycloaddition; AZIDES; alkynes; copper; catalysis; EFFICIENT; 1,2,3-triazoles; TRIAZOLES

The [3+2] cycloaddition of nonactivated terminal alkynes and trimethylsilyl azide proceeded smoothly in the presence of Cu-I catalyst and DMF/MeOH, to give the corresponding N-unsubstituted triazoles in good to high yields. The reaction most probably proceeds through the in situ formation of a coppe...