Nucleotides - LXIII - New 2-(4-nitrophenyl)ethyl(npe)- and 2-(4-nitrophenyl)ethoxycarbonyl(npeoc)-protected 2 '-deoxyribonucleosides and their 3 '-phosphoramidites - Versatile building blocks for oligonucleotide synthesis

• Published in: Helvetica chimica acta Vol. 82; no. 12; pp. 2172 - 2185
• Main Authors: Lang, H, Gottlieb, M, Schwarz, M, Farkas, S, Schulz, BS, Himmelsbach, F, Charubala, R, Pfleiderer, W
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 01.01.1999
• Subjects: Chemistry; Chemistry, Multidisciplinary; Physical Sciences; Science & Technology; OLIGODEOXYNUCLEOTIDES; PROTECTION; SOLID-PHASE SYNTHESIS; NUCLEOSIDES; PHOSPHORAMIDITE APPROACH; OLIGODEOXYRIBONUCLEOTIDES; DERIVATIVES; RESIDUES; CHEMICAL SYNTHESIS; SIDE REACTIONS

A series of new base-protected and 5'-O-(4-monomethoxytrityl)- or 5'-O-(4,4'-dimethoxytrityl)-substituted 3'-(2-cyanoethyl diisopropylphosphoramidites) and 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidites] 52-66 and 67-82, respectively, are prepared as potential buildi...