Theophylline derivatives as potential histamine H-3-receptor antagonists

Previous results of histamine H-3-receptors investigations allowed to formulate a general structure of H-3-receptor antagonists. According to this model a series of compounds were obtained. As heterocycles they contained a theophylline moiety connected with a polar group (amine, ester, amide, and th...

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Published inPharmazie Vol. 53; no. 8; pp. 518 - 521
Main Authors Kiec-Kononowicz, K, Cegla, MT
Format Journal Article
LanguageEnglish
Published ESCHBORN Govi-Verlag Pharmazeutischer Verlag Gmbh 01.08.1998
Subjects
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Physical Sciences
Science & Technology
H-3 RECEPTOR ANTAGONISTS
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Abstract Previous results of histamine H-3-receptors investigations allowed to formulate a general structure of H-3-receptor antagonists. According to this model a series of compounds were obtained. As heterocycles they contained a theophylline moiety connected with a polar group (amine, ester, amide, and thiourea function) via an alkyl chain linked by a spacer to a lipophilic residue. The common distance between xanthine moiety and lipophilic rest was a six-link-chain. Selected compounds did not show significant H-3-receptor antagonist activity and were weak antagonists at histamine H-1-receptors.
AbstractList Previous results of histamine H-3-receptors investigations allowed to formulate a general structure of H-3-receptor antagonists. According to this model a series of compounds were obtained. As heterocycles they contained a theophylline moiety connected with a polar group (amine, ester, amide, and thiourea function) via an alkyl chain linked by a spacer to a lipophilic residue. The common distance between xanthine moiety and lipophilic rest was a six-link-chain. Selected compounds did not show significant H-3-receptor antagonist activity and were weak antagonists at histamine H-1-receptors.
Author Kiec-Kononowicz, K
Cegla, MT
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Snippet Previous results of histamine H-3-receptors investigations allowed to formulate a general structure of H-3-receptor antagonists. According to this model a...
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SubjectTerms Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Physical Sciences
Science & Technology
Title Theophylline derivatives as potential histamine H-3-receptor antagonists
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