Ref-1在阿尔茨海默病大鼠海马CA1区表达的研究
R741; 目的:探讨Ref-1在阿尔茨海默病(AD)大鼠发病中的变化及其可能机制.方法:采用Aβ25-35单次侧脑室注射诱导AD大鼠模型,Y迷宫测定大鼠行为学变化,免疫组化法检测建模后4 d、7 d和14 d时痴呆组、对照组大鼠海马CA1区Ref-1的表达.结果:①Aβ注射7 d、14 d后,痴呆组大鼠达到学习标准的训练次数、错误次数和全天总反应时间较对照组均明显增加(P<0.05).②痴呆组Aβ注射4 d起,海马CA1区Ref-1表达开始增高(P<0.01),随着观察时点的延长,这种表达进一步增高(P<0.01).结论:大鼠侧脑室注射Aβ 7 d可成功诱导AD大鼠模型;R...
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| Published in | 浙江大学学报（医学版） Vol. 37; no. 6; pp. 629 - 633 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
西安交通大学医学院,第二附属医院神经内科,陕西,西安,710004
2008
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-9292 |
| DOI | 10.3785/j.issn.1008-9292.2008.06.014 |
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| Abstract | R741; 目的:探讨Ref-1在阿尔茨海默病(AD)大鼠发病中的变化及其可能机制.方法:采用Aβ25-35单次侧脑室注射诱导AD大鼠模型,Y迷宫测定大鼠行为学变化,免疫组化法检测建模后4 d、7 d和14 d时痴呆组、对照组大鼠海马CA1区Ref-1的表达.结果:①Aβ注射7 d、14 d后,痴呆组大鼠达到学习标准的训练次数、错误次数和全天总反应时间较对照组均明显增加(P<0.05).②痴呆组Aβ注射4 d起,海马CA1区Ref-1表达开始增高(P<0.01),随着观察时点的延长,这种表达进一步增高(P<0.01).结论:大鼠侧脑室注射Aβ 7 d可成功诱导AD大鼠模型;Ref-1的上调早于大鼠记忆障碍的发生,Ref-1可能参与了AD的发生发展. |
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| AbstractList | R741; 目的:探讨Ref-1在阿尔茨海默病(AD)大鼠发病中的变化及其可能机制.方法:采用Aβ25-35单次侧脑室注射诱导AD大鼠模型,Y迷宫测定大鼠行为学变化,免疫组化法检测建模后4 d、7 d和14 d时痴呆组、对照组大鼠海马CA1区Ref-1的表达.结果:①Aβ注射7 d、14 d后,痴呆组大鼠达到学习标准的训练次数、错误次数和全天总反应时间较对照组均明显增加(P<0.05).②痴呆组Aβ注射4 d起,海马CA1区Ref-1表达开始增高(P<0.01),随着观察时点的延长,这种表达进一步增高(P<0.01).结论:大鼠侧脑室注射Aβ 7 d可成功诱导AD大鼠模型;Ref-1的上调早于大鼠记忆障碍的发生,Ref-1可能参与了AD的发生发展. |
| Author | 张桂莲 张茹 吴海琴 姚丽 刘璟洁 杜赟 卜宁 |
| AuthorAffiliation | 西安交通大学医学院,第二附属医院神经内科,陕西,西安,710004 |
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| DocumentTitle_FL | Expression of Ref-1 in hippocampus CA1 area of rats with Alzheimer's disease |
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| Keywords | 疾病模型动物 β-淀粉样蛋白/模型 阿尔茨海默病 Ref-1/海马 淀粉样β蛋白 |
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| Snippet | R741; 目的:探讨Ref-1在阿尔茨海默病(AD)大鼠发病中的变化及其可能机制.方法:采用Aβ25-35单次侧脑室注射诱导AD大鼠模型,Y迷宫测定大鼠行为学变化,免疫组化法检测建模后4 d、7 d和14 d时痴呆组、对照组大鼠海马CA1区Ref-1的表达.结果:①Aβ注射7 d、14... |
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| Title | Ref-1在阿尔茨海默病大鼠海马CA1区表达的研究 |
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