Design and characterizing of robust probes for enhanced mass spectrometry imaging and spatially resolved metabolomics

• Published in: 中国化学快报（英文版） Vol. 34; no. 5; pp. 397 - 402
• Main Authors: Jianpeng Huang, Shanshan Gao, Kai Wang, Jin Zhang, Xuechao Pang, Junwen Shi, Jiuming He
• Format: Journal Article
• Language: English
• Published: NMPA Key Laboratory of Safety Research and Evaluation of Innovative Drug,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China%Viktor Technology Co.,Ltd.,Beijing 101100,China 2023; State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China
• Subjects: Molecular imaging; Spatially resolved metabolomics; Brain; Mass spectrometry imaging; Air-flow assisted desorption electrospray ionization

As for the emerging and cut edge spatially resolved metabolomics,mass spectrometry imaging(MSI)is a powerful tool that can map thousands of metabolites from bio-tissue sections without chemical labels.However,the stability,sensitivity and spatial resolution of MSI are always limited by the performan...