电刺激干预骨代谢相关信号通路研究进展

R681%R285.6; 骨质疏松症(osteoporosis,OP)作为一种患病率逐年递增的临床上常见的全身代谢性疾病,其发病机制与多种信号通路及分子相关.大量动物实验及分子研究分析发现,电刺激引起的电流变化能通过多种直接或间接途径激活成骨细胞(osteoblast,OB)、破骨细胞(osteoclasts,OC),从而促进骨细胞生长.因此合理介导电刺激激活或抑制相关信号通路及分子水平或许是未来深入、系统探究骨质疏松症发病机制及治疗的有效手段.本文旨在总结电刺激与OP发病相关信号通路及分子之间的影响并加以阐述、总结,为OP治疗提供一些新的思路....

Full description

Saved in:
Bibliographic Details
Published in中国骨质疏松杂志 Vol. 29; no. 2; pp. 242 - 247
Main Authors 黄委委, 李鼎鹏, 李宁, 韩宪富, 林德民, 李建国, 丁聚贤, 谢兴文
Format Journal Article
LanguageChinese
Published 甘肃中医药大学,甘肃兰州730000%甘肃省第二人民医院,甘肃兰州730000%甘肃中医药大学附属医院,甘肃兰州730000 2023
Subjects
信号通路
电刺激
生长因子
骨质疏松症
Online AccessGet full text

Cover

Abstract R681%R285.6; 骨质疏松症(osteoporosis,OP)作为一种患病率逐年递增的临床上常见的全身代谢性疾病,其发病机制与多种信号通路及分子相关.大量动物实验及分子研究分析发现,电刺激引起的电流变化能通过多种直接或间接途径激活成骨细胞(osteoblast,OB)、破骨细胞(osteoclasts,OC),从而促进骨细胞生长.因此合理介导电刺激激活或抑制相关信号通路及分子水平或许是未来深入、系统探究骨质疏松症发病机制及治疗的有效手段.本文旨在总结电刺激与OP发病相关信号通路及分子之间的影响并加以阐述、总结,为OP治疗提供一些新的思路.
AbstractList R681%R285.6; 骨质疏松症(osteoporosis,OP)作为一种患病率逐年递增的临床上常见的全身代谢性疾病,其发病机制与多种信号通路及分子相关.大量动物实验及分子研究分析发现,电刺激引起的电流变化能通过多种直接或间接途径激活成骨细胞(osteoblast,OB)、破骨细胞(osteoclasts,OC),从而促进骨细胞生长.因此合理介导电刺激激活或抑制相关信号通路及分子水平或许是未来深入、系统探究骨质疏松症发病机制及治疗的有效手段.本文旨在总结电刺激与OP发病相关信号通路及分子之间的影响并加以阐述、总结,为OP治疗提供一些新的思路.
Author 林德民
李鼎鹏
黄委委
谢兴文
韩宪富
李建国
李宁
丁聚贤
AuthorAffiliation 甘肃中医药大学,甘肃兰州730000%甘肃省第二人民医院,甘肃兰州730000%甘肃中医药大学附属医院,甘肃兰州730000
AuthorAffiliation_xml – name: 甘肃中医药大学,甘肃兰州730000%甘肃省第二人民医院,甘肃兰州730000%甘肃中医药大学附属医院,甘肃兰州730000
Author_FL HAN Xianfu
LI Ning
HUANG Weiwei
LIN Demin
LI Dingpeng
LI Jianguo
XIE Xingwen
DING Juxian
Author_FL_xml – sequence: 1
  fullname: HUANG Weiwei
– sequence: 2
  fullname: LI Dingpeng
– sequence: 3
  fullname: LI Ning
– sequence: 4
  fullname: HAN Xianfu
– sequence: 5
  fullname: LIN Demin
– sequence: 6
  fullname: LI Jianguo
– sequence: 7
  fullname: DING Juxian
– sequence: 8
  fullname: XIE Xingwen
Author_xml – sequence: 1
  fullname: 黄委委
– sequence: 2
  fullname: 李鼎鹏
– sequence: 3
  fullname: 李宁
– sequence: 4
  fullname: 韩宪富
– sequence: 5
  fullname: 林德民
– sequence: 6
  fullname: 李建国
– sequence: 7
  fullname: 丁聚贤
– sequence: 8
  fullname: 谢兴文
BookMark eNrjYmDJy89LZWBQMTTQM7Y0s9TP0sssLs7TMzQwMNM1NzSw0DMyMDLWMzDSMzA0Z2HghItzMPAWF2cmGRgYGZkZWRpZcDKYPZ-y9WnHrmf7G57u3PRyUcvLVSue7F78YsOi57N3PG3d_GT_wqf92182zHqxff3zBVOer9z2Yv_spxun8jCwpiXmFKfyQmluBk031xBnD93yxLy0xLz0-Kz80qI8oEx8VXp6VXFxVRXIRQZGBoYWxqSoBQAHn1g3
ClassificationCodes R681%R285.6
ContentType Journal Article
Copyright Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 2B.
4A8
92I
93N
PSX
TCJ
DOI 10.3969/j.issn.1006-7108.2023.02.017
DatabaseName Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
DocumentTitle_FL Research progress of electrical stimulation on bone metabolism-related signaling pathways
EndPage 247
ExternalDocumentID zggzsszz202302018
GrantInformation_xml – fundername: 中央引导地方科技发展专项项目; (国家自然科学基金); (国家自然科学基金); (甘肃省青年科技基金计划); (中央高校基本科研业务费项目); (敦煌医学与转化教育部重点实验室开放课题); (甘肃省第二人民医院院内重点项目)
  funderid: 中央引导地方科技发展专项项目; (国家自然科学基金); (国家自然科学基金); (甘肃省青年科技基金计划); (中央高校基本科研业务费项目); (敦煌医学与转化教育部重点实验室开放课题); (甘肃省第二人民医院院内重点项目)
GroupedDBID -05
2B.
2C~
4A8
92F
92I
93N
ABDBF
ACGFS
ALMA_UNASSIGNED_HOLDINGS
CCEZO
CIEJG
CW9
EAD
EAP
EAS
EOJEC
EPL
ESX
OBODZ
PSX
TCJ
TGQ
U1G
U5O
ID FETCH-wanfang_journals_zggzsszz2023020183
ISSN 1006-7108
IngestDate Tue Feb 13 23:43:13 EST 2024
IsPeerReviewed false
IsScholarly true
Issue 2
Keywords 信号通路
电刺激
生长因子
骨质疏松症
Language Chinese
LinkModel OpenURL
MergedId FETCHMERGED-wanfang_journals_zggzsszz2023020183
ParticipantIDs wanfang_journals_zggzsszz202302018
PublicationCentury 2000
PublicationDate 2023
PublicationDateYYYYMMDD 2023-01-01
PublicationDate_xml – year: 2023
  text: 2023
PublicationDecade 2020
PublicationTitle 中国骨质疏松杂志
PublicationTitle_FL Chinese Journal of Osteoporosis
PublicationYear 2023
Publisher 甘肃中医药大学,甘肃兰州730000%甘肃省第二人民医院,甘肃兰州730000%甘肃中医药大学附属医院,甘肃兰州730000
Publisher_xml – name: 甘肃中医药大学,甘肃兰州730000%甘肃省第二人民医院,甘肃兰州730000%甘肃中医药大学附属医院,甘肃兰州730000
SSID ssib002262928
ssj0058516
ssib001103816
ssib051369297
Score 4.6868625
Snippet R681%R285.6;...
SourceID wanfang
SourceType Aggregation Database
StartPage 242
Title 电刺激干预骨代谢相关信号通路研究进展
URI https://d.wanfangdata.com.cn/periodical/zggzsszz202302018
Volume 29
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LbxMxELZKKiEuCASItyrUOXBIyL689tGbeFUhwalIvVW7ecElSCS95FQJkLhxKRd6gXIBLrwE5XHIn2lI8i-YsTfJUiJoAWm1GtmemW881nrs3fEyttxMkrrbrPm4LHHDos8bSVHyZr1Yq3GMbpsyFSHlDt-4yVdu-dfXgrWFwv3cV0sb3bRU683NK_kbr2IZ-pWyZA_h2alQLEAa_Yt39DDeD-Rj0CFIH6IAdABCQKRAc4hi-nwBSyIJkQtagnJB-IZQoARoZIlAeaCRpUy1JCeCSBg5yOiZNjEox5TEEIXETl9FKMMVgoqJS5UJABGoi5uqmESRdgfsjy0nsa-RKUBVqZbUVXOQkNE3BCLhpBENkVWIdEYI18hE4dOJk7jRDrIsAGV6YkLMmlhmbdpWJgRaEs9pgswahJOXL2OyzNYgUiKwdyv5vRKbyGzGdeYPaexBxML7yWZRIbxUVTXdh8J8wksElnAc7vMkWJdYj2KtprP_6d_awbzGWIJmOsYlFboIgCLVlsiGCLrNyUFCQ80o-Q8ADmOv1WsdSMNF_yOk3AxLW1gY1or8FJxtet3J7YRk86k9ei0LzVx7OOv-Wd-TXJpZnxSUpgpKNALMgbw2O3jfueq9VqvX6fR61ArXTI44whbdUAZ-gS2qqBrFs1WFY16v56Je7srZqj1wPI6LjOk-D71oN0mNEyBH2XKG8trvMJq0wXYzabdyEe7qCXY8W5ouKfucOckWerdPMT7c-jh49PV7f3Pw5f1458H49cu9by9Gb3eG258HDz_s9Z8PHu-ON5-Odt8Mn20NX30a9bcH756cZldjvVpZKWa61rPnWWf9lw7xzrBC-267cZYtpfQGXfB6Egap78gkSUMf49hyUgu8gKflc-zKn-WdP0ijC-wY0XaX8yIrdO9tNC5h3N9NL2d--QEmxreq
link.rule.ids 315,786,790,4043,27954,27955,27956
linkProvider EBSCOhost
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E7%94%B5%E5%88%BA%E6%BF%80%E5%B9%B2%E9%A2%84%E9%AA%A8%E4%BB%A3%E8%B0%A2%E7%9B%B8%E5%85%B3%E4%BF%A1%E5%8F%B7%E9%80%9A%E8%B7%AF%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95&rft.jtitle=%E4%B8%AD%E5%9B%BD%E9%AA%A8%E8%B4%A8%E7%96%8F%E6%9D%BE%E6%9D%82%E5%BF%97&rft.au=%E9%BB%84%E5%A7%94%E5%A7%94&rft.au=%E6%9D%8E%E9%BC%8E%E9%B9%8F&rft.au=%E6%9D%8E%E5%AE%81&rft.au=%E9%9F%A9%E5%AE%AA%E5%AF%8C&rft.date=2023&rft.pub=%E7%94%98%E8%82%83%E4%B8%AD%E5%8C%BB%E8%8D%AF%E5%A4%A7%E5%AD%A6%2C%E7%94%98%E8%82%83%E5%85%B0%E5%B7%9E730000%25%E7%94%98%E8%82%83%E7%9C%81%E7%AC%AC%E4%BA%8C%E4%BA%BA%E6%B0%91%E5%8C%BB%E9%99%A2%2C%E7%94%98%E8%82%83%E5%85%B0%E5%B7%9E730000%25%E7%94%98%E8%82%83%E4%B8%AD%E5%8C%BB%E8%8D%AF%E5%A4%A7%E5%AD%A6%E9%99%84%E5%B1%9E%E5%8C%BB%E9%99%A2%2C%E7%94%98%E8%82%83%E5%85%B0%E5%B7%9E730000&rft.issn=1006-7108&rft.volume=29&rft.issue=2&rft.spage=242&rft.epage=247&rft_id=info:doi/10.3969%2Fj.issn.1006-7108.2023.02.017&rft.externalDocID=zggzsszz202302018
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzggzsszz%2Fzggzsszz.jpg