The role ofα- andβ- adrenergic receptors in the spasmolytic effects on rat ileum ofPetroselinum crispumLatifolum (parsley)

• Published in: 亚太热带医药杂志（英文版） no. 11; pp. 866 - 870
• Main Authors: N MirzaieDamabi, AA Moazedi, SM Seyyednejad
• Format: Journal Article
• Language: English
• Published: School of Science, Department of Biology, Shahid Chamran University, Ahwaz, Iran 2010
• Subjects: Relaxation; Latifolum; Petroselinum crispum; Adrenergic receptors; Ileum
• ISSN: 1995-7645

Objective:To investigatePetroselinum crispumLatifolum (parsley) for treating stomach and intestinal disorders in Iran.Methods:An80% ethanol extract was prepared from parsley seeds, and its antispasmodic activity assessed by measuring contractions of isolated ilea induced by60 mM potassium chloride(KCl). A piece of ileum from an adult male Wistar rat was dissected and mounted in an organ bath containing Tyrode's solution, and ileum contractions were recorded by an isotonic transducer under one gram resting tension. The effect of parsley extract was measured in the presence of two antagonists’ of α- and β-adrenoceptors.Results: These experiments showed that parsley extract inhibited the response to 60 mMKCl in a concentration-dependent manner (P<0.01,n=7). The spasmolytic effect of parsley extract was unaffected by1 μM phentolamine or1 μM propranolol.Conclusions: This study shows that parsley seed extract is a relaxant of isolated rat ileum and the relaxation effect of extract does not involved adrenergic receptors.