高效液相色谱法测定血液透析患者缬沙坦血药浓度
R459.5; 目的 探讨血液透析对缬沙坦血药浓度的影响.方法 收集2018年1月至2022年1月于北京中医药大学厦门医院门诊就诊及住院的55例血液透析患者相关资料,受试者在血液透析前6 h服用缬沙坦胶囊80 mg,采集透析开始时及透析结束时透析器中静脉血,采用高效液相色谱法测定血药浓度.结果 缬沙坦低、中、高浓度的回收率分别为(100.75±1.36)％、(103.12±1.02)％、(101.68±2.37)％,相对标准偏差分别为1.35％、0.99％、2.33％.透析后缬沙坦血药浓度(0.47 μg/mL)低于透析前(0.67 μg/mL),差异有统计学意义(P＜0.01).患者年龄、血...
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| Published in | 现代医药卫生 Vol. 40; no. 22; pp. 3781 - 3785 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
北京中医药大学厦门医院,福建厦门 361009%厦门华夏学院,福建厦门 361024
2024
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1009-5519 |
| DOI | 10.3969/j.issn.1009-5519.2024.22.001 |
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| Abstract | R459.5; 目的 探讨血液透析对缬沙坦血药浓度的影响.方法 收集2018年1月至2022年1月于北京中医药大学厦门医院门诊就诊及住院的55例血液透析患者相关资料,受试者在血液透析前6 h服用缬沙坦胶囊80 mg,采集透析开始时及透析结束时透析器中静脉血,采用高效液相色谱法测定血药浓度.结果 缬沙坦低、中、高浓度的回收率分别为(100.75±1.36)％、(103.12±1.02)％、(101.68±2.37)％,相对标准偏差分别为1.35％、0.99％、2.33％.透析后缬沙坦血药浓度(0.47 μg/mL)低于透析前(0.67 μg/mL),差异有统计学意义(P＜0.01).患者年龄、血浆白蛋白、尿素氮、血肌酐与血药浓度均无相关性(P＞0.01).结论 缬沙坦在血液透析后血药浓度呈下降趋势. |
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| AbstractList | R459.5; 目的 探讨血液透析对缬沙坦血药浓度的影响.方法 收集2018年1月至2022年1月于北京中医药大学厦门医院门诊就诊及住院的55例血液透析患者相关资料,受试者在血液透析前6 h服用缬沙坦胶囊80 mg,采集透析开始时及透析结束时透析器中静脉血,采用高效液相色谱法测定血药浓度.结果 缬沙坦低、中、高浓度的回收率分别为(100.75±1.36)％、(103.12±1.02)％、(101.68±2.37)％,相对标准偏差分别为1.35％、0.99％、2.33％.透析后缬沙坦血药浓度(0.47 μg/mL)低于透析前(0.67 μg/mL),差异有统计学意义(P＜0.01).患者年龄、血浆白蛋白、尿素氮、血肌酐与血药浓度均无相关性(P＞0.01).结论 缬沙坦在血液透析后血药浓度呈下降趋势. |
| Abstract_FL | Objective To investigate the effect of hemodialysis on plasma concentration of valsartan.Methods The relevant data of 55 hemodialysis patients in Xiamen Hospital Affiliated to Beijing University of Traditional Chinese Medicine from January 2018 to January 2022 were collected.The subjects took 80 mg of valsartan capsule 6 hours before hemodialysis,and the venous blood was collected from the dialyzer at the be-ginning and end of dialysis,and the plasma concentration was determined by high performance liquid chroma-tography.Results The recovery rates of valsartan at low,medium and high concentrations were(100.75±1.36)％,(103.12±1.02)％and(101.68±2.37)％,respectively,and the relative standard deviation were 1.35％,0.99％and 2.33％,respectively.The plasma concentration of valsartan after dialysis(0.47 μg/mL)was lower than that before dialysis(0.67 μg/mL),the difference was statistically significant(P＜0.01).There was no correlation between age,plasma albumin,urea nitrogen,serum creatinine and plasma concentration(P＞0.01).Conclusion The plasma concentration of valsartan shows a downward trend after hemodialysis. |
| Author | 许正锦 王海烨 郑凤伟 文娱 赖源发 陈慧 蔡丽娜 许勇镇 吴玲艳 |
| AuthorAffiliation | 北京中医药大学厦门医院,福建厦门 361009%厦门华夏学院,福建厦门 361024 |
| AuthorAffiliation_xml | – name: 北京中医药大学厦门医院,福建厦门 361009%厦门华夏学院,福建厦门 361024 |
| Author_FL | CHEN Hui XU Zhengjin WU Lingyan LAI Yuanfa WANG Haihua CAI Lina WEN Yu XU Yongzhen ZHENG Fengwei |
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| Author_xml | – sequence: 1 fullname: 王海烨 – sequence: 2 fullname: 许正锦 – sequence: 3 fullname: 赖源发 – sequence: 4 fullname: 郑凤伟 – sequence: 5 fullname: 陈慧 – sequence: 6 fullname: 许勇镇 – sequence: 7 fullname: 吴玲艳 – sequence: 8 fullname: 蔡丽娜 – sequence: 9 fullname: 文娱 |
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| DocumentTitle_FL | Determination of valsartan plasma concentration in hemodialysis patients by high performance liquid chromatography |
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| Keywords | Hypertension End-stage renal disease 缬沙坦 Valsartan 高血压 Hemodialysis 高效液相色谱 血液透析 High performance liquid chromatography 终末期肾病 |
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| Title | 高效液相色谱法测定血液透析患者缬沙坦血药浓度 |
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