生酮饮食对海人酸点燃癫(痫)模型大鼠海马神经元保护作用研究

目的 探讨生酮饮食对海人酸点燃癫(痫)模型大鼠海马神经元的保护作用.方法 经海人酸制备SD大鼠癫(痫)模型,分别给予生理盐水+正常膳食(C组)、生理盐水+生酮饮食(K组)、海人酸+正常膳食(E组)和海人酸+生酮饮食(EK组),连续观察21d后记录不同处理组大鼠体重、观察Ⅳ或Ⅴ级癫(痫)发作频率和持续时间,并通过HE染色和Nissl染色计数E组和EK组大鼠海马CA3区正常锥体神经元数目.结果 C组和K组大鼠均无癫(痫)发作,且海马CA3区锥体神经元数目正常.E组和EK组大鼠在观察过程中均出现Ⅳ或Ⅴ级癫(痫)发作,但EK组大鼠在饲养第21天时与E组相比,癫(痫)发作频率减少[(17.90±4.12...

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Published in中国现代神经疾病杂志 Vol. 15; no. 11; pp. 890 - 895
Main Authors 张楠楠, 丛琳, 方秀英, 冯雪梅, 朱喜科
Format Journal Article
LanguageChinese
Published 中国医科大学附属盛京医院神经功能科,沈阳,110004%中国医科大学附属盛京医院神经内科,沈阳,110004%中国医科大学附属盛京医院实验研究中心,沈阳,110004 2015
Subjects
神经元
Neurons
Epilepsy
Ketone bodies
膳食疗法
海人酸
Diet therapy
癫(痫)
海马
酮体类
Kainic acid
Hippocampus
疾病模型,动物
Disease models,animal
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Abstract 目的 探讨生酮饮食对海人酸点燃癫(痫)模型大鼠海马神经元的保护作用.方法 经海人酸制备SD大鼠癫(痫)模型,分别给予生理盐水+正常膳食(C组)、生理盐水+生酮饮食(K组)、海人酸+正常膳食(E组)和海人酸+生酮饮食(EK组),连续观察21d后记录不同处理组大鼠体重、观察Ⅳ或Ⅴ级癫(痫)发作频率和持续时间,并通过HE染色和Nissl染色计数E组和EK组大鼠海马CA3区正常锥体神经元数目.结果 C组和K组大鼠均无癫(痫)发作,且海马CA3区锥体神经元数目正常.E组和EK组大鼠在观察过程中均出现Ⅳ或Ⅴ级癫(痫)发作,但EK组大鼠在饲养第21天时与E组相比,癫(痫)发作频率减少[(17.90±4.12)次对(30.50±4.40)次,P=0.000]、发作持续时间缩短[(212.70± 17.75)s对(335.00±14.21)s,P=0.000],差异有统计学意义;EK组海马CA3区正常锥体神经元数目与E组相比增加[(117.67±7.51)个对(71.33±6.11)个,P=0.000],差异亦有统计学意义.结论 生酮饮食对海人酸点燃癫(痫)模型大鼠海马神经元具有保护作用.
AbstractList 目的 探讨生酮饮食对海人酸点燃癫(痫)模型大鼠海马神经元的保护作用.方法 经海人酸制备SD大鼠癫(痫)模型,分别给予生理盐水+正常膳食(C组)、生理盐水+生酮饮食(K组)、海人酸+正常膳食(E组)和海人酸+生酮饮食(EK组),连续观察21d后记录不同处理组大鼠体重、观察Ⅳ或Ⅴ级癫(痫)发作频率和持续时间,并通过HE染色和Nissl染色计数E组和EK组大鼠海马CA3区正常锥体神经元数目.结果 C组和K组大鼠均无癫(痫)发作,且海马CA3区锥体神经元数目正常.E组和EK组大鼠在观察过程中均出现Ⅳ或Ⅴ级癫(痫)发作,但EK组大鼠在饲养第21天时与E组相比,癫(痫)发作频率减少[(17.90±4.12)次对(30.50±4.40)次,P=0.000]、发作持续时间缩短[(212.70± 17.75)s对(335.00±14.21)s,P=0.000],差异有统计学意义;EK组海马CA3区正常锥体神经元数目与E组相比增加[(117.67±7.51)个对(71.33±6.11)个,P=0.000],差异亦有统计学意义.结论 生酮饮食对海人酸点燃癫(痫)模型大鼠海马神经元具有保护作用.
Author 丛琳
张楠楠
方秀英
朱喜科
冯雪梅
AuthorAffiliation 中国医科大学附属盛京医院神经功能科,沈阳,110004%中国医科大学附属盛京医院神经内科,沈阳,110004%中国医科大学附属盛京医院实验研究中心,沈阳,110004
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Author_FL ZHU Xi-ke
FANG Xiu-ying
CONG Lin
ZHANG Nan-nan
FENG Xue-mei
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DocumentTitle_FL Study on protective effect of ketogenic diet against hippocampal neurons of kainic acid-induced epileptic rats
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Issue 11
Keywords 神经元
Neurons
Epilepsy
Ketone bodies
膳食疗法
海人酸
Diet therapy
癫(痫)
海马
酮体类
Kainic acid
Hippocampus
疾病模型,动物
Disease models,animal
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PublicationTitle 中国现代神经疾病杂志
PublicationTitle_FL Chinese Journal of Contemporary Neurology and Neurosurgery
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Publisher 中国医科大学附属盛京医院神经功能科,沈阳,110004%中国医科大学附属盛京医院神经内科,沈阳,110004%中国医科大学附属盛京医院实验研究中心,沈阳,110004
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