脐带间充质干细胞治疗脑胶质瘤:作用机制、安全性和未来应用前景

R394.2; 背景:脐带间充质干细胞是一类具有自我更新能力、高度增殖能力和多向分化潜能的细胞.脐带间充质干细胞的特性尤其是肿瘤嗜性能力使其成为神经胶质瘤细胞治疗的理想工具.这些细胞可以通过旁分泌或者作为基因和药物的递送系统起作用.已经证明脐带间充质干细胞能够抑制脑胶质瘤的生长并改善移植入大脑后的存活.目的:总结脐带间充质干细胞在脑胶质瘤治疗中分子机制和安全性的研究和进展,并为其进一步研究提供有益的参考.方法:应用计算机检索2000至2017年 PubMed 和 CNKI 数据库相关文章,英文检索词为"Glioma;Umbilical cord mesenchymal stem ce...

Full description

Saved in:
Bibliographic Details
Published in中国组织工程研究 Vol. 22; no. 17; pp. 2740 - 2746
Main Authors 周馨魁, 马珊珊, 刘腾飞, 周建康, 邢衢, 黄团结, 王亚苹, 杨波, 关方霞
Format Journal Article
LanguageChinese
Published 郑州大学第一附属医院神经外科,河南省郑州市 450052 2018
郑州大学生命科学学院,河南省郑州市,450001%郑州大学第一附属医院神经外科,河南省郑州市,450052%郑州大学生命科学学院,河南省郑州市 450001
Subjects
脑胶质瘤
脐带间充质干细胞
细胞治疗
细胞因子
干细胞
安全性
分子机制
综述
Online AccessGet full text
ISSN2095-4344
DOI10.3969/j.issn.2095-4344.0530

Cover

Abstract R394.2; 背景:脐带间充质干细胞是一类具有自我更新能力、高度增殖能力和多向分化潜能的细胞.脐带间充质干细胞的特性尤其是肿瘤嗜性能力使其成为神经胶质瘤细胞治疗的理想工具.这些细胞可以通过旁分泌或者作为基因和药物的递送系统起作用.已经证明脐带间充质干细胞能够抑制脑胶质瘤的生长并改善移植入大脑后的存活.目的:总结脐带间充质干细胞在脑胶质瘤治疗中分子机制和安全性的研究和进展,并为其进一步研究提供有益的参考.方法:应用计算机检索2000至2017年 PubMed 和 CNKI 数据库相关文章,英文检索词为"Glioma;Umbilical cord mesenchymal stem cells",中文检索词为"胶质瘤;脐带间充质干细胞;安全性;分子机制".根据纳入与排除标准,最终保留55篇文献进行综述.结果与结论:①脐带间充质干细胞治疗脑胶质瘤有着明显的作用;②脐带间充质干细胞可以通过其归巢特征、旁分泌机制、作为基因载体和共培养对脑胶质瘤进行治疗;③脐带间充质干细胞在脑胶质瘤的治疗中具有一定的安全性.
AbstractList R394.2; 背景:脐带间充质干细胞是一类具有自我更新能力、高度增殖能力和多向分化潜能的细胞.脐带间充质干细胞的特性尤其是肿瘤嗜性能力使其成为神经胶质瘤细胞治疗的理想工具.这些细胞可以通过旁分泌或者作为基因和药物的递送系统起作用.已经证明脐带间充质干细胞能够抑制脑胶质瘤的生长并改善移植入大脑后的存活.目的:总结脐带间充质干细胞在脑胶质瘤治疗中分子机制和安全性的研究和进展,并为其进一步研究提供有益的参考.方法:应用计算机检索2000至2017年 PubMed 和 CNKI 数据库相关文章,英文检索词为"Glioma;Umbilical cord mesenchymal stem cells",中文检索词为"胶质瘤;脐带间充质干细胞;安全性;分子机制".根据纳入与排除标准,最终保留55篇文献进行综述.结果与结论:①脐带间充质干细胞治疗脑胶质瘤有着明显的作用;②脐带间充质干细胞可以通过其归巢特征、旁分泌机制、作为基因载体和共培养对脑胶质瘤进行治疗;③脐带间充质干细胞在脑胶质瘤的治疗中具有一定的安全性.
Abstract_FL BACKGROUND: Umbilical cord mesenchymal stem cells (UC-MSCs) are a group of cells that have self-renewal, highly proliferative and multidrug differentiation potential. The properties of UC-MSCs and their tumor tropism make them an ideal tool for glioma cell therapy. These cells can act by paracrine or as a delivery system for genes and drugs. It has been demonstrated that UC-MSCs can inhibit the growth of glioma and improve the survival after transplantation into the brain. OBJECTIVE: To summarize the molecular mechanisms and safety of UC-MSCs in the treatment of glioma and to provide a useful reference for further research. METHODS: We searched the PubMed and CNKI databases from 2000 to 2017 with the English terms of "glioma; umbilical cord mesenchymal stem cells" and the Chinese terms of "glioma; umbilical cord mesenchymal stem cells; safety; molecular mechanism". Based on the inclusion and exclusion criteria, 55 articles were finally reserved for review. RESULTS AND CONCLUSION: UC-MSCs have obvious effect on treating glioma. These cells can treat glioma through homing mechanism and paracrine mechanism as gene carrier and co-culture. Moreover, UC-MSCs have certain safety in the treatment of glioma.
Author 周馨魁
王亚苹
邢衢
杨波
关方霞
黄团结
刘腾飞
周建康
马珊珊
AuthorAffiliation 郑州大学生命科学学院,河南省郑州市,450001%郑州大学第一附属医院神经外科,河南省郑州市,450052%郑州大学生命科学学院,河南省郑州市 450001;郑州大学第一附属医院神经外科,河南省郑州市 450052
AuthorAffiliation_xml – name: 郑州大学生命科学学院,河南省郑州市,450001%郑州大学第一附属医院神经外科,河南省郑州市,450052%郑州大学生命科学学院,河南省郑州市 450001;郑州大学第一附属医院神经外科,河南省郑州市 450052
Author_FL Ma Shan-shan
Yang Bo
Xing Qu
Zhou Xin-kui
Liu Teng-fei
Wang Ya-ping
Zhou Jian-kang
Huang Tuan-jie
Guan Fang-xia
Author_FL_xml – sequence: 1
  fullname: Zhou Xin-kui
– sequence: 2
  fullname: Ma Shan-shan
– sequence: 3
  fullname: Liu Teng-fei
– sequence: 4
  fullname: Zhou Jian-kang
– sequence: 5
  fullname: Xing Qu
– sequence: 6
  fullname: Huang Tuan-jie
– sequence: 7
  fullname: Wang Ya-ping
– sequence: 8
  fullname: Yang Bo
– sequence: 9
  fullname: Guan Fang-xia
Author_xml – sequence: 1
  fullname: 周馨魁
– sequence: 2
  fullname: 马珊珊
– sequence: 3
  fullname: 刘腾飞
– sequence: 4
  fullname: 周建康
– sequence: 5
  fullname: 邢衢
– sequence: 6
  fullname: 黄团结
– sequence: 7
  fullname: 王亚苹
– sequence: 8
  fullname: 杨波
– sequence: 9
  fullname: 关方霞
BookMark eNrjYmDJy89LZWCQNTTQM7Y0s9TP0sssLs7TMzKwNNU1MTYx0TMwNTZgYeCEC3Aw8BYXZyYZmBqZmJmbG1lyMkS8aJnwdMeyl9O3PG1tfbFlxdOdm57vbnvRPO_Zpt3Pp01_0TLxRfM2oPjzGUusnuyd83zKimdzdj3t2Pa4ofHpus6nrSueNSx_Oqnn2ZxVz-YufbprClDB087eZzPX8zCwpiXmFKfyQmluBlU31xBnD93yxLy0xLz0-Kz80qI8oEx8RUp2mpGBoYWhuYGRoTGx6gALXmnE
ClassificationCodes R394.2
ContentType Journal Article
Copyright Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 2B.
4A8
92I
93N
PSX
TCJ
DOI 10.3969/j.issn.2095-4344.0530
DatabaseName Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
DocumentTitle_FL Treating glioma with umbilical cord mesenchymal stem cells: mechanism of action, safety and future application
EndPage 2746
ExternalDocumentID xdkf201817021
GrantInformation_xml – fundername: 国家自然科学基金资助项目; 河南省高校科技创新团队基金资助项目; 河南省科技创新人才计划基金资助项目 the National Natural Science Foundation of China, No. U1404313, 81471306, 81601078; Henan Provincial University Science and Technology Innovation Team Funded Project, No. 15IRTSTHN022; Henan Science and Technology Innovation Talents Program, No. 154200510008
  funderid: (U1404313,81471306,81601078); (15IRTSTHN022); (154200510008) the National Natural Science Foundation of China, No. U1404313, 81471306, 81601078; Henan Provincial University Science and Technology Innovation Team Funded Project, No. 15IRTSTHN022; Henan Science and Technology Innovation Talents Program, No. 154200510008
GroupedDBID 2B.
4A8
92F
92I
93N
ALMA_UNASSIGNED_HOLDINGS
PSX
TCJ
TGQ
U1G
U5O
ID FETCH-wanfang_journals_xdkf2018170213
ISSN 2095-4344
IngestDate Thu May 29 04:11:46 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 17
Keywords 脑胶质瘤
脐带间充质干细胞
细胞治疗
细胞因子
干细胞
安全性
分子机制
综述
Language Chinese
LinkModel OpenURL
MergedId FETCHMERGED-wanfang_journals_xdkf2018170213
ParticipantIDs wanfang_journals_xdkf201817021
PublicationCentury 2000
PublicationDate 2018
PublicationDateYYYYMMDD 2018-01-01
PublicationDate_xml – year: 2018
  text: 2018
PublicationDecade 2010
PublicationTitle 中国组织工程研究
PublicationTitle_FL Chinese Journal of Tissue Engineering Research
PublicationYear 2018
Publisher 郑州大学第一附属医院神经外科,河南省郑州市 450052
郑州大学生命科学学院,河南省郑州市,450001%郑州大学第一附属医院神经外科,河南省郑州市,450052%郑州大学生命科学学院,河南省郑州市 450001
Publisher_xml – name: 郑州大学第一附属医院神经外科,河南省郑州市 450052
– name: 郑州大学生命科学学院,河南省郑州市,450001%郑州大学第一附属医院神经外科,河南省郑州市,450052%郑州大学生命科学学院,河南省郑州市 450001
SSID ssib052467729
ssib051369104
ssib013936551
ssib014787831
ssj0002511089
ssib017477121
Score 4.202678
Snippet R394.2;...
SourceID wanfang
SourceType Aggregation Database
StartPage 2740
Title 脐带间充质干细胞治疗脑胶质瘤:作用机制、安全性和未来应用前景
URI https://d.wanfangdata.com.cn/periodical/xdkf201817021
Volume 22
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3daxNBED9K-uKLKCp-lj64IEhq7mNvd33by10ogj5V6FvJ5RIFIYK2IH2qtBELCirFKkSf_Cg-KJRStMW_Ri-J_4Uzc5vcFYIfhXLszc7O_G5mczP7dbWsi47dFI3Ea5TrXgwDlEaSlOs8icuNOI6bHmTMLQcPOF-_4c_e9K7N8_mJ0qXCrqWlxXimsTz2XMlhvAo08Cuekv0Pz46EAgHK4F-4gofh-k8-ZpFk0mOqwiLOAsm0zyLFlGCBhxRJf8ADt1oSj2KBwyJgCJj0qbnLVMQiH-lAhCrlowQj2TY8gV-QAzygywOULPJYEDJVJWJW6-NtoAmApIYubqeQNlJ0xKQy2DJmqNICKcphsmqaa02FkGlOsDUKz1VwFCJD4lFMH9iaSJAAXkgyA4RnntcbFkhdIEi4QIGSHlxXjBYNVhpNWJIYm9QqNLAphEzaOYvCNpqsIGtM6lGhKAWsAXZDe4L2iBqh8cco4ggzMyFcA1GcmjFxBH9GKAL9Z5vnQUdydExmUMCIHUIgMMRGdgFzYxdRZA5oZZtWYHp0P1Vp6iJgHazKTFYzklUmUKBSpzrsNy5JCKnfCPQfOnscNgTgXPY4LhPkIciBBLzsudkXOofx0nGK7wVRjH4i-_SWyaTg1h8XpV3lK4rSqGNmpGMG4kElT0tGm0UfJHdaaF1bVPCLEZOOEDYvWZM6CIPaMHbAQMb1eb7CbeNHp2S-wg0Db2iWp6rcdn1VmIrgDmQMwxVszOJw6F2h_6A5ApgdAET0V8Zip3N_7Va9fauQos4ds46aseW0zl4Ux62J5dsnrPnB2rP064dfmztppzPY2Uq_bff3Hw1W3_a29_svNwdrzweru0Dvv3p39ef3bn9jq9fdSx_v_lh5mH5eTztbvZWP6Ysnve6n3pv36d4GMKTrT3uvv5y0WC2aq86WDZoF88q6v3DAlO4pq9S-226etqYFpLGy6TrNhLc83ojriajErkwEhPvY9ZIz1tSfZZ39G8M56wiWs8nL81Zp8d5S8wKk84vxlPHkb03mu8k
linkProvider EBSCOhost
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E8%84%90%E5%B8%A6%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%91%E8%83%B6%E8%B4%A8%E7%98%A4%3A%E4%BD%9C%E7%94%A8%E6%9C%BA%E5%88%B6%E3%80%81%E5%AE%89%E5%85%A8%E6%80%A7%E5%92%8C%E6%9C%AA%E6%9D%A5%E5%BA%94%E7%94%A8%E5%89%8D%E6%99%AF&rft.jtitle=%E4%B8%AD%E5%9B%BD%E7%BB%84%E7%BB%87%E5%B7%A5%E7%A8%8B%E7%A0%94%E7%A9%B6&rft.au=%E5%91%A8%E9%A6%A8%E9%AD%81&rft.au=%E9%A9%AC%E7%8F%8A%E7%8F%8A&rft.au=%E5%88%98%E8%85%BE%E9%A3%9E&rft.au=%E5%91%A8%E5%BB%BA%E5%BA%B7&rft.date=2018&rft.pub=%E9%83%91%E5%B7%9E%E5%A4%A7%E5%AD%A6%E7%AC%AC%E4%B8%80%E9%99%84%E5%B1%9E%E5%8C%BB%E9%99%A2%E7%A5%9E%E7%BB%8F%E5%A4%96%E7%A7%91%2C%E6%B2%B3%E5%8D%97%E7%9C%81%E9%83%91%E5%B7%9E%E5%B8%82+450052&rft.issn=2095-4344&rft.volume=22&rft.issue=17&rft.spage=2740&rft.epage=2746&rft_id=info:doi/10.3969%2Fj.issn.2095-4344.0530&rft.externalDocID=xdkf201817021
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fxdkf%2Fxdkf.jpg