超高效液相色谱-串联质谱法测定牛奶中4种 β-内酰胺类抗生素及其主要代谢产物

目的 建立超高效液相色谱-串联质谱法检测牛奶中青霉素G、青霉素V、氨苄西林、阿莫西林及其代谢产物脱羧噻唑酸含量的分析方法.方法 样品经0.2％氨水乙腈溶液超声离心提取,通过Oasis PRiME HLB固相萃取柱进行净化,采用超高效液相色谱-串联质谱法进行测定.结果 青霉素G、青霉素V、氨苄西林、阿莫西林及其代谢产物脱羧噻唑酸在所考察的线性范围内线性良好,相关系数不低于0.999;方法 回收率为70.9％～101.6％,相对标准偏差(relative standard deviation,RSD)为4.0％～7.5％.市售的35份样品中,均未检出青霉素G、青霉素V、阿莫西林、氨苄西林及其代谢产...

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Published in食品安全质量检测学报 Vol. 12; no. 5; pp. 1662 - 1668
Main Authors 路杨, 王丽英, 秦振顺, 任贝贝, 刘梦颖, 常凤启
Format Journal Article
LanguageChinese
Published 河北省疾病预防控制中心, 石家庄 050021 2021
Subjects
超高效液相色谱-串联质谱法
牛奶
β-内酰胺类抗生素
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Abstract 目的 建立超高效液相色谱-串联质谱法检测牛奶中青霉素G、青霉素V、氨苄西林、阿莫西林及其代谢产物脱羧噻唑酸含量的分析方法.方法 样品经0.2％氨水乙腈溶液超声离心提取,通过Oasis PRiME HLB固相萃取柱进行净化,采用超高效液相色谱-串联质谱法进行测定.结果 青霉素G、青霉素V、氨苄西林、阿莫西林及其代谢产物脱羧噻唑酸在所考察的线性范围内线性良好,相关系数不低于0.999;方法 回收率为70.9％～101.6％,相对标准偏差(relative standard deviation,RSD)为4.0％～7.5％.市售的35份样品中,均未检出青霉素G、青霉素V、阿莫西林、氨苄西林及其代谢产物.结论 该方法操作简单、重现性好,可用于牛奶中青霉素G、青霉素V、阿莫西林、氨苄西林及其代谢产物脱羧噻唑酸的检测.
AbstractList 目的 建立超高效液相色谱-串联质谱法检测牛奶中青霉素G、青霉素V、氨苄西林、阿莫西林及其代谢产物脱羧噻唑酸含量的分析方法.方法 样品经0.2％氨水乙腈溶液超声离心提取,通过Oasis PRiME HLB固相萃取柱进行净化,采用超高效液相色谱-串联质谱法进行测定.结果 青霉素G、青霉素V、氨苄西林、阿莫西林及其代谢产物脱羧噻唑酸在所考察的线性范围内线性良好,相关系数不低于0.999;方法 回收率为70.9％～101.6％,相对标准偏差(relative standard deviation,RSD)为4.0％～7.5％.市售的35份样品中,均未检出青霉素G、青霉素V、阿莫西林、氨苄西林及其代谢产物.结论 该方法操作简单、重现性好,可用于牛奶中青霉素G、青霉素V、阿莫西林、氨苄西林及其代谢产物脱羧噻唑酸的检测.
Author 任贝贝
王丽英
秦振顺
路杨
常凤启
刘梦颖
AuthorAffiliation 河北省疾病预防控制中心, 石家庄 050021
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LIU Meng-Ying
QIN Zhen-Shun
REN Bei-Bei
LU Yang
CHANG Feng-Qi
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  fullname: 路杨
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牛奶
β-内酰胺类抗生素
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Snippet 目的 建立超高效液相色谱-串联质谱法检测牛奶中青霉素G、青霉素V、氨苄西林、阿莫西林及其代谢产物脱羧噻唑酸含量的分析方法.方法 样品经0.2％氨水乙腈溶液超声离心提取,通过Oasis PRiME HLB固相萃取柱进行净化,采用超高效液相色谱-串联质谱法进行测定.结果...
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Title 超高效液相色谱-串联质谱法测定牛奶中4种 β-内酰胺类抗生素及其主要代谢产物
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