骨关节炎发生发展相关信号通路的研究进展
R684.3; 骨关节炎(OA)是以关节进行性退变为特征,以关节疼痛为主要临床表现的退行性疾病.在OA的发生发展过程中各种信号通路起到重要作用,目前研究较多的有MAPK信号通路、Notch信号通路、Wnt信号通路、TGF-β信号通路、NF-κB信号通路及mTOR信号通路.以上信号通路多可被外界刺激激活,在炎性反应的调控、软骨细胞及细胞外基质的代谢调节中起重要作用.通过对这些信号通路的研究,寻找通路上游或下游的关节效应因子,可为OA提供更加行之有效的治疗方法....
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| Published in | 山东医药 Vol. 60; no. 16; pp. 84 - 88 |
|---|---|
| Main Authors | , , , |
| Format | Magazine Article |
| Language | Chinese |
| Published |
山西医科大学第二医院,太原,030000
2020
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1002-266X |
| DOI | 10.3969/j.issn.1002-266X.2020.16.024 |
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| Abstract | R684.3; 骨关节炎(OA)是以关节进行性退变为特征,以关节疼痛为主要临床表现的退行性疾病.在OA的发生发展过程中各种信号通路起到重要作用,目前研究较多的有MAPK信号通路、Notch信号通路、Wnt信号通路、TGF-β信号通路、NF-κB信号通路及mTOR信号通路.以上信号通路多可被外界刺激激活,在炎性反应的调控、软骨细胞及细胞外基质的代谢调节中起重要作用.通过对这些信号通路的研究,寻找通路上游或下游的关节效应因子,可为OA提供更加行之有效的治疗方法. |
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| AbstractList | R684.3; 骨关节炎(OA)是以关节进行性退变为特征,以关节疼痛为主要临床表现的退行性疾病.在OA的发生发展过程中各种信号通路起到重要作用,目前研究较多的有MAPK信号通路、Notch信号通路、Wnt信号通路、TGF-β信号通路、NF-κB信号通路及mTOR信号通路.以上信号通路多可被外界刺激激活,在炎性反应的调控、软骨细胞及细胞外基质的代谢调节中起重要作用.通过对这些信号通路的研究,寻找通路上游或下游的关节效应因子,可为OA提供更加行之有效的治疗方法. |
| Author | 王越 王新军 袁银鹏 王宇泽 |
| AuthorAffiliation | 山西医科大学第二医院,太原,030000 |
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| Keywords | Notch信号通路 TGF-β信号通路 信号通路 骨关节炎 MAPK信号通路 Wnt信号通路 NF-κB信号通路 mTOR信号通路 |
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| Title | 骨关节炎发生发展相关信号通路的研究进展 |
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