瘦素与银屑病的研究进展

银屑病是一种常见的免疫炎症性系统性疾病,常合并肥胖等代谢综合征.瘦素作为最经典的促炎性脂肪因子,在银屑病领域受到持续关注.目前普遍认为瘦素对银屑病起着促进作用.本文主要综述瘦素与银屑病发生发展和代谢相关合并症的关联性,以及瘦素在银屑病免疫炎症激活、表皮角质形成细胞增殖分化和促炎因子分泌、真皮乳头毛细血管增生扩张等病理过程中的可能作用机制....

Full description

Saved in:
Bibliographic Details
Published in皮肤性病诊疗学杂志 Vol. 31; no. 3; pp. 198 - 202
Main Authors 陈琳, 熊慧, 郭庆
Format Journal Article
LanguageChinese
Published 中山大学孙逸仙纪念医院,广东 广州 510030 2024
Subjects
银屑病
瘦素
角质形成细胞
psoriasis
capillaries
免疫细胞
毛细血管
immune cells
keratinocytes
leptin
Online AccessGet full text
ISSN1674-8468
DOI10.3969/j.issn.1674-8468.2024.03.009

Cover

Abstract 银屑病是一种常见的免疫炎症性系统性疾病,常合并肥胖等代谢综合征.瘦素作为最经典的促炎性脂肪因子,在银屑病领域受到持续关注.目前普遍认为瘦素对银屑病起着促进作用.本文主要综述瘦素与银屑病发生发展和代谢相关合并症的关联性,以及瘦素在银屑病免疫炎症激活、表皮角质形成细胞增殖分化和促炎因子分泌、真皮乳头毛细血管增生扩张等病理过程中的可能作用机制.
AbstractList 银屑病是一种常见的免疫炎症性系统性疾病,常合并肥胖等代谢综合征.瘦素作为最经典的促炎性脂肪因子,在银屑病领域受到持续关注.目前普遍认为瘦素对银屑病起着促进作用.本文主要综述瘦素与银屑病发生发展和代谢相关合并症的关联性,以及瘦素在银屑病免疫炎症激活、表皮角质形成细胞增殖分化和促炎因子分泌、真皮乳头毛细血管增生扩张等病理过程中的可能作用机制.
Abstract_FL Psoriasis,a systemic immune-inflammatory disease,is often associated with meta-bolic syndromes such as obesity.As the most classical pro-inflammatory adipokine,leptin has re-ceived persistent attention in psoriasis.Currently,it is generally believed that leptin promotes the development of psoriasis.This article delves into the intricate relationship between leptin and the development of psoriasis,along with its associated metabolic complications.Additionally,the po-tential mechanisms by which leptin operates in the pathological processes of psoriasis,such as im-mune inflammatory activation,epidermal keratinocyte proliferation,differentiation and secretion of proinflammatory factors,and proliferation and dilatation of dermal papillary capillaries,are ex-plored.
Author 熊慧
郭庆
陈琳
AuthorAffiliation 中山大学孙逸仙纪念医院,广东 广州 510030
AuthorAffiliation_xml – name: 中山大学孙逸仙纪念医院,广东 广州 510030
Author_FL CHEN Lin
XIONG Hui
GUO Qing
Author_FL_xml – sequence: 1
  fullname: CHEN Lin
– sequence: 2
  fullname: XIONG Hui
– sequence: 3
  fullname: GUO Qing
Author_xml – sequence: 1
  fullname: 陈琳
– sequence: 2
  fullname: 熊慧
– sequence: 3
  fullname: 郭庆
BookMark eNrjYmDJy89LZWBQMTTQM7Y0s9TP0sssLs7TMzQzN9G1MDGz0DMyMDLRMzDWMzCwZGHghItzMPAWF2cmGZgaGpubmJmbcTIoPp-x7PmWBU929L2cvO3pxonPp7c-n9XyfMGU5yu3vdg_--nGqTwMrGmJOcWpvFCam0HLzTXE2UO3PDEvLTEvPT4rv7QoDygTn5NXkFaRlF1VBbLdwBhotzFJigFXyEk5
ContentType Journal Article
Copyright Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 2B.
4A8
92I
93N
PSX
TCJ
DOI 10.3969/j.issn.1674-8468.2024.03.009
DatabaseName Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
DocumentTitle_FL The role of leptin in psoriasis
EndPage 202
ExternalDocumentID lnpfxbkzz202403009
GrantInformation_xml – fundername: (广东省自然科学基金); (广东省医师协会皮肤研究专项课题)
  funderid: (广东省自然科学基金); (广东省医师协会皮肤研究专项课题)
GroupedDBID -05
2B.
4A8
92I
93N
ALMA_UNASSIGNED_HOLDINGS
CCEZO
CIEJG
GROUPED_DOAJ
PSX
TCJ
ID FETCH-wanfang_journals_lnpfxbkzz2024030093
ISSN 1674-8468
IngestDate Thu May 29 03:58:13 EDT 2025
IsPeerReviewed false
IsScholarly true
Issue 3
Keywords 银屑病
瘦素
角质形成细胞
psoriasis
capillaries
免疫细胞
毛细血管
immune cells
keratinocytes
leptin
Language Chinese
LinkModel OpenURL
MergedId FETCHMERGED-wanfang_journals_lnpfxbkzz2024030093
ParticipantIDs wanfang_journals_lnpfxbkzz202403009
PublicationCentury 2000
PublicationDate 2024
PublicationDateYYYYMMDD 2024-01-01
PublicationDate_xml – year: 2024
  text: 2024
PublicationDecade 2020
PublicationTitle 皮肤性病诊疗学杂志
PublicationTitle_FL Journal of Diagnosis and Therapy on Dermato-venereology
PublicationYear 2024
Publisher 中山大学孙逸仙纪念医院,广东 广州 510030
Publisher_xml – name: 中山大学孙逸仙纪念医院,广东 广州 510030
SSID ssib051374676
ssib036439063
ssj0002923811
ssib007124007
ssib011909005
ssib052606345
Score 4.679944
Snippet ...
SourceID wanfang
SourceType Aggregation Database
StartPage 198
Title 瘦素与银屑病的研究进展
URI https://d.wanfangdata.com.cn/periodical/lnpfxbkzz202403009
Volume 31
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Pi9QwFA_rCuJFFBV1VVbcXBw69k-SvhzT2Q6LoKcV9ra0M62KUsWdBZmzXgVRUfSyJ8Hjgize_DIu1W_he2mmU1mRURjKa_LeLy9507yXNGkYWxMxDpMVaE-AP8IBSlR4GUDh5WWAXaYuy7Gi_c6376iNu-LWltxaOtbrrFraneT90fSP-0r-x6qYhnalXbL_YNkWFBOQRvviFS2M14VszNOYa-BGEZEIbnyeCp4Ah5SnmuuIJ5gleRJwHVjmmIO0hOEgiEAR3RDaMgNPhlwnMynZDV6doEmJDUJuUFDRUgkTd8BRnyEHY1MUJSKUWbdK4u06CRI4ltK6QKus5gBWyOdJNM9BUGXhFKGb32QgImRCw-qo7gRGOJ-6dE3iGAP6kUbCat2qZgnUgVB94iepxKbEBG-M0zqRRMCAchu1TYj_U5uriaEpTg96nSQksGJpD7sm370gahyBioWHsRl0PYXzVw-6Ewm22w-ak7RdBBHaPeRHnFOklbbOiQrotwX0qU2aD-3quVNul0o-qp6Uz_KH0ymxoYq0WfV4GMeB7MwfUOcZB-HsjHu6DzDS052jCCIKPf35t9ZkENFJM20sKnFgqyL3ipnCmFBTNGcnLGaqnmBrrh43_1YLu_-tKrPqXidU2zzNTrkx1qppHpgzbGl6_yy7Vr__VH_Z-_715c_XB4f7r-p3L-oPz-u9N_Xngx_fPh7uvz3HbgzTzcGG52C33TO4s320daLzbLl6XBUX2OpY5UqVSgnIYuEXkI38cQbBSIYZyLHyL7LrCwBeWohrhZ0kupmcu8yWJ093iysYrk7yq9ZMvwCbA2dl
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E7%98%A6%E7%B4%A0%E4%B8%8E%E9%93%B6%E5%B1%91%E7%97%85%E7%9A%84%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95&rft.jtitle=%E7%9A%AE%E8%82%A4%E6%80%A7%E7%97%85%E8%AF%8A%E7%96%97%E5%AD%A6%E6%9D%82%E5%BF%97&rft.au=%E9%99%88%E7%90%B3&rft.au=%E7%86%8A%E6%85%A7&rft.au=%E9%83%AD%E5%BA%86&rft.date=2024&rft.pub=%E4%B8%AD%E5%B1%B1%E5%A4%A7%E5%AD%A6%E5%AD%99%E9%80%B8%E4%BB%99%E7%BA%AA%E5%BF%B5%E5%8C%BB%E9%99%A2%2C%E5%B9%BF%E4%B8%9C+%E5%B9%BF%E5%B7%9E+510030&rft.issn=1674-8468&rft.volume=31&rft.issue=3&rft.spage=198&rft.epage=202&rft_id=info:doi/10.3969%2Fj.issn.1674-8468.2024.03.009&rft.externalDocID=lnpfxbkzz202403009
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Flnpfxbkzz%2Flnpfxbkzz.jpg