高效液相色谱法同时测定蜈蚣药材中5种成分含量

R28; 为建立蜈蚣药材中次黄嘌呤、黄嘌呤、硫酸-3-羟基喹啉、硫酸-3-羟基-4-甲氧基喹啉、3,8-二羟基喹啉的一测多评含量测定方法(quantitative analysis of multi-components by single-marker,QAMS),采用高效液相色谱法(high performance liquid chromatography,HPLC),以次黄嘌呤为内参物分别计算4个待测组分(黄嘌呤、硫酸-3-羟基喹啉、硫酸-3-羟基-4-甲氧基喹啉、3,8-二羟基喹啉)与次黄嘌呤的相对校正因子,并采用外标法和QAMS法同时测定14批蜈蚣药材中成分含量以验证QAMS法的准...

Full description

Saved in:
Bibliographic Details
Published in科学技术与工程 Vol. 23; no. 1; pp. 91 - 99
Main Authors 马云, 马庆文, 范建伟, 李倩, 申凤霞, 关永霞, 张贵民
Format Journal Article
LanguageChinese
Published 中药制药共性技术国家重点实验室,临沂276006%鲁南制药集团股份有限公司, 临沂276006%中药制药共性技术国家重点实验室,临沂276006 2023
鲁南厚普制药有限公司, 临沂276006
鲁南制药集团股份有限公司, 临沂276006
Subjects
蜈蚣药材
高效液相色谱法
成分含量
Online AccessGet full text

Cover

Abstract R28; 为建立蜈蚣药材中次黄嘌呤、黄嘌呤、硫酸-3-羟基喹啉、硫酸-3-羟基-4-甲氧基喹啉、3,8-二羟基喹啉的一测多评含量测定方法(quantitative analysis of multi-components by single-marker,QAMS),采用高效液相色谱法(high performance liquid chromatography,HPLC),以次黄嘌呤为内参物分别计算4个待测组分(黄嘌呤、硫酸-3-羟基喹啉、硫酸-3-羟基-4-甲氧基喹啉、3,8-二羟基喹啉)与次黄嘌呤的相对校正因子,并采用外标法和QAMS法同时测定14批蜈蚣药材中成分含量以验证QAMS法的准确性.结果表明,HPLC法测定蜈蚣药材中5种成分含量的方法适用性良好,以次黄嘌呤为内参物,计算得黄嘌呤、硫酸-3-羟基喹啉、硫酸-3-羟基-4-甲氧基喹啉、3,8-二羟基喹啉的相对校正因子分别为1.67、9.01、5.03、0.76,相对保留值分别为1.22、2.65、3.04、3.52;外标法和QAMS法测得14批蜈蚣药材中5种成分含量无显著差异(P>0.05);可见以次黄嘌呤为内参物建立了蜈蚣药材5种成分的一测多评含量测定法,可用于蜈蚣药材的定量分析与质量评价.
AbstractList R28; 为建立蜈蚣药材中次黄嘌呤、黄嘌呤、硫酸-3-羟基喹啉、硫酸-3-羟基-4-甲氧基喹啉、3,8-二羟基喹啉的一测多评含量测定方法(quantitative analysis of multi-components by single-marker,QAMS),采用高效液相色谱法(high performance liquid chromatography,HPLC),以次黄嘌呤为内参物分别计算4个待测组分(黄嘌呤、硫酸-3-羟基喹啉、硫酸-3-羟基-4-甲氧基喹啉、3,8-二羟基喹啉)与次黄嘌呤的相对校正因子,并采用外标法和QAMS法同时测定14批蜈蚣药材中成分含量以验证QAMS法的准确性.结果表明,HPLC法测定蜈蚣药材中5种成分含量的方法适用性良好,以次黄嘌呤为内参物,计算得黄嘌呤、硫酸-3-羟基喹啉、硫酸-3-羟基-4-甲氧基喹啉、3,8-二羟基喹啉的相对校正因子分别为1.67、9.01、5.03、0.76,相对保留值分别为1.22、2.65、3.04、3.52;外标法和QAMS法测得14批蜈蚣药材中5种成分含量无显著差异(P>0.05);可见以次黄嘌呤为内参物建立了蜈蚣药材5种成分的一测多评含量测定法,可用于蜈蚣药材的定量分析与质量评价.
Author 马庆文
马云
关永霞
李倩
张贵民
范建伟
申凤霞
AuthorAffiliation 鲁南厚普制药有限公司, 临沂276006;中药制药共性技术国家重点实验室,临沂276006%鲁南制药集团股份有限公司, 临沂276006%中药制药共性技术国家重点实验室,临沂276006;鲁南制药集团股份有限公司, 临沂276006
AuthorAffiliation_xml – name: 鲁南厚普制药有限公司, 临沂276006;中药制药共性技术国家重点实验室,临沂276006%鲁南制药集团股份有限公司, 临沂276006%中药制药共性技术国家重点实验室,临沂276006;鲁南制药集团股份有限公司, 临沂276006
Author_FL MA Qing-wen
GUAN Yong-xia
ZHANG Gui-min
FAN Jian-wei
LI Qian
MA Yun
SHEN Feng-xia
Author_FL_xml – sequence: 1
  fullname: MA Yun
– sequence: 2
  fullname: MA Qing-wen
– sequence: 3
  fullname: FAN Jian-wei
– sequence: 4
  fullname: LI Qian
– sequence: 5
  fullname: SHEN Feng-xia
– sequence: 6
  fullname: GUAN Yong-xia
– sequence: 7
  fullname: ZHANG Gui-min
Author_xml – sequence: 1
  fullname: 马云
– sequence: 2
  fullname: 马庆文
– sequence: 3
  fullname: 范建伟
– sequence: 4
  fullname: 李倩
– sequence: 5
  fullname: 申凤霞
– sequence: 6
  fullname: 关永霞
– sequence: 7
  fullname: 张贵民
BookMark eNrjYmDJy89LZWBQMTTQM7Y0s9TP0sssLs7TMzQzN9Q1tDA01TMyMDLWMzAEIgMWBk64OAcDb3FxZpKBgQFQl4mROSeDw8vVM55N7Xi2bdPz2TtedG56sWHjs81Tn07oeTZ927Ot3U_XzXoxp-PFrMUvetc_mzvhyY61ps-X9z7rmPC0o-3phNUv2_t5GFjTEnOKU3mhNDeDhptriLOHbnliXlpiXnp8Vn5pUR5QJj67Iqu4Mj0Z5DSgswwNjElQCgCsX1x5
ClassificationCodes R28
ContentType Journal Article
Copyright Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 2B.
4A8
92I
93N
PSX
TCJ
DOI 10.3969/j.issn.1671-1815.2023.01.010
DatabaseName Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
DocumentTitle_FL Simultaneous Determination of Five Components in Centipede Medicinal Materials by High Performance Liquid Chromatography
EndPage 99
ExternalDocumentID kxjsygc202301010
GrantInformation_xml – fundername: (山东省重点研发计划); (临沂市自主创新重大专项)
  funderid: (山东省重点研发计划); (临沂市自主创新重大专项)
GroupedDBID 2B.
4A8
92I
93N
ALMA_UNASSIGNED_HOLDINGS
CDYEO
PSX
TCJ
ID FETCH-wanfang_journals_kxjsygc2023010103
ISSN 1671-1815
IngestDate Wed Nov 06 04:33:42 EST 2024
IsPeerReviewed false
IsScholarly true
Issue 1
Keywords 蜈蚣药材
高效液相色谱法
成分含量
Language Chinese
LinkModel OpenURL
MergedId FETCHMERGED-wanfang_journals_kxjsygc2023010103
ParticipantIDs wanfang_journals_kxjsygc202301010
PublicationCentury 2000
PublicationDate 2023
PublicationDateYYYYMMDD 2023-01-01
PublicationDate_xml – year: 2023
  text: 2023
PublicationDecade 2020
PublicationTitle 科学技术与工程
PublicationTitle_FL Science Technology and Engineering
PublicationYear 2023
Publisher 中药制药共性技术国家重点实验室,临沂276006%鲁南制药集团股份有限公司, 临沂276006%中药制药共性技术国家重点实验室,临沂276006
鲁南厚普制药有限公司, 临沂276006
鲁南制药集团股份有限公司, 临沂276006
Publisher_xml – name: 鲁南厚普制药有限公司, 临沂276006
– name: 鲁南制药集团股份有限公司, 临沂276006
– name: 中药制药共性技术国家重点实验室,临沂276006%鲁南制药集团股份有限公司, 临沂276006%中药制药共性技术国家重点实验室,临沂276006
SSID ssib000969427
ssib051374925
ssib002258142
ssib001129818
ssib018829817
ssib006563779
ssib048878216
ssib036435880
Score 4.6854672
Snippet R28; 为建立蜈蚣药材中次黄嘌呤、黄嘌呤、硫酸-3-羟基喹啉、硫酸-3-羟基-4-甲氧基喹啉、3,8-二羟基喹啉的一测多评含量测定方法(quantitative analysis of multi-components by single-marker,QAMS),采用高效液相色谱法(high...
SourceID wanfang
SourceType Aggregation Database
StartPage 91
Title 高效液相色谱法同时测定蜈蚣药材中5种成分含量
URI https://d.wanfangdata.com.cn/periodical/kxjsygc202301010
Volume 23
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwzR1NaxNBdKgpiBdRVPymggNeErMfsztzcya7oXjwVKG3kt0mFYUINgXtD9CIFnMpStWTBw_Fr4qlP8aj2ab_wvfeTpJtCbV6EsKyO_O-5r3Zee_NzkwYu-4ErUSBWy0nrheW_VCEuAhgsSybXtpymtRvcLXFnWD2rn97XsxPlX4WVi2tdJJKujpxX8m_WBXKwK64S_YvLDsiCgVwD_aFK1gYrkeyMY8V14YryeOAK8El3Rj4uTwOuTLcQInkUlGJ5KbKjUMwHsLHgqsqlzVCDxERq4COwSodc6URS9WIssRH7RHBiOs6YUVIIfaRkY4EctUhVkMd4GAdiSUDywzEBaElwOxbUGgRlUOMgTqJIjUuxEA2NeJHbGSMMAbgc3ZQMvpsRAqBX41gNVfOhBqBNZIYKOARjkEk6kJ6BGIQCqnUuKqPQajJuQggmlbFWZN8SzP18JFKCtoiRaCOiyXCGgSJhZPaLMiMkTUIoufqi7Dx0uVGDW0VUxs12ZNKtA8vkJXE-GRbF1Bc_EoacFcgPJaQ0oEgdIEJQioUwNrPcE39CPhqhyjnspG00MsQWA2tLqy2ZR0FgFf5UFH-d30VvHcQOmUIWUXRvVvbF4ex3FfbLphHffm_dB2MJzwVKIonkHxlRL6CPYpO-7VLsvef2P7g8f3lJ0spAuEJjtVjbNoFNyhKbFqbyNSL0wfKd8fhP-Y-shArgq-Vjj9OPyD3wvNBh88OZMcAP8L3ILsQBX8Mvhni_3H6JxwvxLNIcQ5q2JTjMFzn7bx5WCtpS2O71WgvFaLvuVPspE2bZ3Q-Bp5mU6v3zrBbe5tvsvVutr21-3Zn8Hxr8PVb9n2933uZvd7Ofrzof94YvOsONj4M1r5k73u_dj6J3Y9rWbfX7z7t9zb3nr06y27U47nabNlyXbCj7vLCQeV651ip_bDdPM9mRKsRNF03cX3IaRtBmjh-YzENGqlIIUlKqxfYtT-Su3gEmEvsBN7nE7GXWanzaKV5BVKTTnLVWvg32TfchQ
link.rule.ids 315,783,787,4031,27935,27936,27937
linkProvider EBSCOhost
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E9%AB%98%E6%95%88%E6%B6%B2%E7%9B%B8%E8%89%B2%E8%B0%B1%E6%B3%95%E5%90%8C%E6%97%B6%E6%B5%8B%E5%AE%9A%E8%9C%88%E8%9A%A3%E8%8D%AF%E6%9D%90%E4%B8%AD5%E7%A7%8D%E6%88%90%E5%88%86%E5%90%AB%E9%87%8F&rft.jtitle=%E7%A7%91%E5%AD%A6%E6%8A%80%E6%9C%AF%E4%B8%8E%E5%B7%A5%E7%A8%8B&rft.au=%E9%A9%AC%E4%BA%91&rft.au=%E9%A9%AC%E5%BA%86%E6%96%87&rft.au=%E8%8C%83%E5%BB%BA%E4%BC%9F&rft.au=%E6%9D%8E%E5%80%A9&rft.date=2023&rft.pub=%E4%B8%AD%E8%8D%AF%E5%88%B6%E8%8D%AF%E5%85%B1%E6%80%A7%E6%8A%80%E6%9C%AF%E5%9B%BD%E5%AE%B6%E9%87%8D%E7%82%B9%E5%AE%9E%E9%AA%8C%E5%AE%A4%2C%E4%B8%B4%E6%B2%82276006%25%E9%B2%81%E5%8D%97%E5%88%B6%E8%8D%AF%E9%9B%86%E5%9B%A2%E8%82%A1%E4%BB%BD%E6%9C%89%E9%99%90%E5%85%AC%E5%8F%B8%2C+%E4%B8%B4%E6%B2%82276006%25%E4%B8%AD%E8%8D%AF%E5%88%B6%E8%8D%AF%E5%85%B1%E6%80%A7%E6%8A%80%E6%9C%AF%E5%9B%BD%E5%AE%B6%E9%87%8D%E7%82%B9%E5%AE%9E%E9%AA%8C%E5%AE%A4%2C%E4%B8%B4%E6%B2%82276006&rft.issn=1671-1815&rft.volume=23&rft.issue=1&rft.spage=91&rft.epage=99&rft_id=info:doi/10.3969%2Fj.issn.1671-1815.2023.01.010&rft.externalDocID=kxjsygc202301010
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fkxjsygc%2Fkxjsygc.jpg