miR-140表达与肿瘤发生发展关系的研究进展

R739.2; MicroRNA是真核生物中一类小分子非编码RNA,长约22个核苷酸,通过影响mRNA的稳定性及其翻译过程而在转录后水平调节基因的表达.研究发现,microRNA在多种肿瘤中表达失调,与肿瘤的发生、发展密切相关,在肿瘤中发挥抑癌或促癌作用.miR-140在乳腺癌、肺癌、肝癌、结肠癌和骨肉瘤等多种肿瘤中呈低表达,通过调控多种靶基因参与调节肿瘤细胞的增殖、分化、侵袭和转移等,被认为是一种具有抑癌作用的microRNA.本文就miR-140在常见肿瘤中的研究现状作一综述....

Full description

Saved in:
Bibliographic Details
Published in解放军医学杂志 Vol. 43; no. 6; pp. 523 - 529
Main Authors 李维娜, 何飞
Format Journal Article
LanguageChinese
Published 710032,西安 空军军医大学基础医学院%475003,河南开封 解放军95982部队卫生连 2018
Subjects
肿瘤抑制因子
肿瘤
miR-140
基因
微RNAs
Online AccessGet full text

Cover

Abstract R739.2; MicroRNA是真核生物中一类小分子非编码RNA,长约22个核苷酸,通过影响mRNA的稳定性及其翻译过程而在转录后水平调节基因的表达.研究发现,microRNA在多种肿瘤中表达失调,与肿瘤的发生、发展密切相关,在肿瘤中发挥抑癌或促癌作用.miR-140在乳腺癌、肺癌、肝癌、结肠癌和骨肉瘤等多种肿瘤中呈低表达,通过调控多种靶基因参与调节肿瘤细胞的增殖、分化、侵袭和转移等,被认为是一种具有抑癌作用的microRNA.本文就miR-140在常见肿瘤中的研究现状作一综述.
AbstractList R739.2; MicroRNA是真核生物中一类小分子非编码RNA,长约22个核苷酸,通过影响mRNA的稳定性及其翻译过程而在转录后水平调节基因的表达.研究发现,microRNA在多种肿瘤中表达失调,与肿瘤的发生、发展密切相关,在肿瘤中发挥抑癌或促癌作用.miR-140在乳腺癌、肺癌、肝癌、结肠癌和骨肉瘤等多种肿瘤中呈低表达,通过调控多种靶基因参与调节肿瘤细胞的增殖、分化、侵袭和转移等,被认为是一种具有抑癌作用的microRNA.本文就miR-140在常见肿瘤中的研究现状作一综述.
Author 何飞
李维娜
AuthorAffiliation 710032,西安 空军军医大学基础医学院%475003,河南开封 解放军95982部队卫生连
AuthorAffiliation_xml – name: 710032,西安 空军军医大学基础医学院%475003,河南开封 解放军95982部队卫生连
Author_FL LI Wei-na
HE Fei
Author_FL_xml – sequence: 1
  fullname: LI Wei-na
– sequence: 2
  fullname: HE Fei
Author_xml – sequence: 1
  fullname: 李维娜
– sequence: 2
  fullname: 何飞
BookMark eNrjYmDJy89LZWBQMTTQMzS0MDXVz9LLLC7O0zMwNTfXNTcxMNIzMjC00DMw0zM0YWHghAtzMPAWF2cmGRgYGhqYmBiacTKY52YG6RqaGLxYuOLFvn1PdvS9aNr_fMaSp_0Tn0-ZDySfbpz6tHXz8827n89qeb5gyvOV217snw0U5GFgTUvMKU7lhdLcDBpuriHOHrrliXlpiXnp8Vn5pUV5QJn4rLSsyoqqKpCDDMwMDE2MSVAKAKrBVFg
ClassificationCodes R739.2
ContentType Journal Article
Copyright Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 2B.
4A8
92I
93N
PSX
TCJ
DOI 10.11855/j.issn.0577-7402.2018.06.14
DatabaseName Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
DocumentTitle_FL Research progress on the role of miR-140 expression in the development of tumor
EndPage 529
ExternalDocumentID jfjyxzz201806014
GrantInformation_xml – fundername: 国家自然科学基金
  funderid: (81300325)
GroupedDBID -05
2B.
2C~
3V.
4A8
5VS
5XA
5XF
92F
92I
93N
ABUWG
ACGFS
AFKRA
ALMA_UNASSIGNED_HOLDINGS
BENPR
BPHCQ
BVBZV
CCEZO
CCPQU
CIEJG
CW9
GROUPED_DOAJ
IPNFZ
KQ8
PQQKQ
PROAC
PSX
RIG
RNS
TCJ
TGQ
U1G
U5O
ID FETCH-wanfang_journals_jfjyxzz2018060143
ISSN 0577-7402
IngestDate Tue Feb 13 23:31:50 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 6
Keywords 肿瘤抑制因子
肿瘤
miR-140
基因
微RNAs
Language Chinese
LinkModel OpenURL
MergedId FETCHMERGED-wanfang_journals_jfjyxzz2018060143
ParticipantIDs wanfang_journals_jfjyxzz201806014
PublicationCentury 2000
PublicationDate 2018
PublicationDateYYYYMMDD 2018-01-01
PublicationDate_xml – year: 2018
  text: 2018
PublicationDecade 2010
PublicationTitle 解放军医学杂志
PublicationTitle_FL Medical Journal of Chinese People's Liberation Army
PublicationYear 2018
Publisher 710032,西安 空军军医大学基础医学院%475003,河南开封 解放军95982部队卫生连
Publisher_xml – name: 710032,西安 空军军医大学基础医学院%475003,河南开封 解放军95982部队卫生连
SSID ssib001104416
ssib002263991
ssib046619461
ssib051375714
ssj0058562
ssib038074682
Score 4.317445
Snippet R739.2;...
SourceID wanfang
SourceType Aggregation Database
StartPage 523
Title miR-140表达与肿瘤发生发展关系的研究进展
URI https://d.wanfangdata.com.cn/periodical/jfjyxzz201806014
Volume 43
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3daxQxEA_tFYov4id-U6EBoWzdj2STPG7uchShRUqFvpXu3Z5a8AS9gt6j6KsiVBB9UEFBH6UggtD-Mx57f4Yz2dze9oNahSOEucnMbzK3m0luZ5aQWem3ZZrywMtYmmJR7cCTaai8tuIdP4rSjrLp0YtL8cIddmuVr05Mfqk8tbTZS-db_UPzSv7Hq0ADv2KW7D94thQKBOiDf6EFD0N7LB8_uL_swdaFGkmTgCYSO9rgxzCqJZUGKTKkukmNoArYGDWcyiZVgaUwqpoVCqc6oIpbCvQj5IFWa8ucUMmwk_g4EDuK6tgqheG6HF4NeC024ARRMY5CbCA8dvyyboVzmjRoElueBgJGUSCzXCRH3xiLSFNt7QCLVX3MAtIbFr1CfcpUTzTc7Rd_fVhpKArht2WxWUUoy1Cp5kZWJXtRHoTL0Koxbo7ziKMEekL6h9mmqAJgoJgzCKD8yCKIqQ7tRAM_gLcydd1J0D4E-nNHTKHCwogoWUbW_Qp97DwKSnXFx4WTTOXGz4XwBPP3rFJFMSt3NVaXHF7ka7vohRfnRwcXRsm5XRlRw3ypAZ9ttAVsi0zefaXHNzobT5_0-8iDZXvYJJkKBWyoa2RKm6Xby-O4Gzb11b-vIaaHwLdcOPClBiweF1FiMZ6djROqeRAJLjBOLEIo2MLaNwGXMKfJ7MiIm0eYYBPvup317t1KjLhyipx0m7uZpLhST5OJ_r0zZHrRPb5ylgh3wQ4_fR3u7Pz--XL4bDd_-3nw6nW-9QHawfc3gxfb-fav_N3z_ONW_u3HcPc9EM-RG02zUl_wnN41d3d4vLZ_7qLzpNZ92M0ukBkZRlnkZ3EmcDfTZjJej1KGGVWCt0SLXyTX_yru0jF4LpMT2C8ODK-QWu_RZnYVQuhees058A-0lo4f
link.rule.ids 315,786,790,4043,27956,27957,27958
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=miR-140%E8%A1%A8%E8%BE%BE%E4%B8%8E%E8%82%BF%E7%98%A4%E5%8F%91%E7%94%9F%E5%8F%91%E5%B1%95%E5%85%B3%E7%B3%BB%E7%9A%84%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95&rft.jtitle=%E8%A7%A3%E6%94%BE%E5%86%9B%E5%8C%BB%E5%AD%A6%E6%9D%82%E5%BF%97&rft.au=%E6%9D%8E%E7%BB%B4%E5%A8%9C&rft.au=%E4%BD%95%E9%A3%9E&rft.date=2018&rft.pub=710032%2C%E8%A5%BF%E5%AE%89+%E7%A9%BA%E5%86%9B%E5%86%9B%E5%8C%BB%E5%A4%A7%E5%AD%A6%E5%9F%BA%E7%A1%80%E5%8C%BB%E5%AD%A6%E9%99%A2%25475003%2C%E6%B2%B3%E5%8D%97%E5%BC%80%E5%B0%81+%E8%A7%A3%E6%94%BE%E5%86%9B95982%E9%83%A8%E9%98%9F%E5%8D%AB%E7%94%9F%E8%BF%9E&rft.issn=0577-7402&rft.volume=43&rft.issue=6&rft.spage=523&rft.epage=529&rft_id=info:doi/10.11855%2Fj.issn.0577-7402.2018.06.14&rft.externalDocID=jfjyxzz201806014
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fjfjyxzz%2Fjfjyxzz.jpg