肺癌7项抗体水平与NSCLC患者化疗效果及预后的关系
R734.2; 目的 研究肺癌 7 项抗体水平与非小细胞肺癌(NSCLC)患者化疗效果及预后转归的关系.方法 选取太和县人民医院从 2022 年6 月至2023 年12 月收治的42 例NSCLC患者开展研究.所有受试者均进行4 个周期的化学治疗(化疗).将其按照化疗疗效的差异分作有效组(n=25)与无效组(n=17).对比两组肺癌 7 项抗体水平,并以受试者工作特征(ROC)曲线分析肺癌 7 项抗体评估NSCLC患者化疗疗效的效能.此外,将受试者按照预后转归的差异分作预后良好组(n=21)及预后不良组(n=21).对比两组肺癌 7 项抗体水平,并以多因素Logistic回归分析明确肺癌 7...
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| Published in | 基础医学与临床 Vol. 44; no. 10; pp. 1383 - 1387 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
太和县人民医院 肿瘤放疗科,安徽 阜阳 236000%安徽医科大学第一附属医院 肿瘤放疗科 安徽合肥 230000
2024
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| Abstract | R734.2; 目的 研究肺癌 7 项抗体水平与非小细胞肺癌(NSCLC)患者化疗效果及预后转归的关系.方法 选取太和县人民医院从 2022 年6 月至2023 年12 月收治的42 例NSCLC患者开展研究.所有受试者均进行4 个周期的化学治疗(化疗).将其按照化疗疗效的差异分作有效组(n=25)与无效组(n=17).对比两组肺癌 7 项抗体水平,并以受试者工作特征(ROC)曲线分析肺癌 7 项抗体评估NSCLC患者化疗疗效的效能.此外,将受试者按照预后转归的差异分作预后良好组(n=21)及预后不良组(n=21).对比两组肺癌 7 项抗体水平,并以多因素Logistic回归分析明确肺癌 7 项抗体水平与NSCLC患者预后转归的关系.结果 化疗有效组肺癌 7 项抗体水平均低于无效组(P＜0.05).经ROC曲线分析证实,肺癌 7 项抗体(CAGE、GAGE7、GBU4-5、P53、PGP95、SOX2、MAGEA1)评估NSCLC患者化疗疗效的效能均较佳,曲线下面积分别为 0.861、0.769、0.778、0.786、0.793、0.842、0.833.预后不良组肺癌 7 项抗体水平均高于预后良好组(P＜0.05).经多因素Logistic回归分析证实,肺癌 7 项抗体为NSCLC患者预后不良的危险因素水平(OR＞1,P＜0.05).结论 肺癌 7 项抗体水平与NSCLC患者化疗效果及预后密切相关,随着肺癌 7 项抗体水平的升高,NSCLC患者化疗效果及预后越差. |
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| AbstractList | R734.2; 目的 研究肺癌 7 项抗体水平与非小细胞肺癌(NSCLC)患者化疗效果及预后转归的关系.方法 选取太和县人民医院从 2022 年6 月至2023 年12 月收治的42 例NSCLC患者开展研究.所有受试者均进行4 个周期的化学治疗(化疗).将其按照化疗疗效的差异分作有效组(n=25)与无效组(n=17).对比两组肺癌 7 项抗体水平,并以受试者工作特征(ROC)曲线分析肺癌 7 项抗体评估NSCLC患者化疗疗效的效能.此外,将受试者按照预后转归的差异分作预后良好组(n=21)及预后不良组(n=21).对比两组肺癌 7 项抗体水平,并以多因素Logistic回归分析明确肺癌 7 项抗体水平与NSCLC患者预后转归的关系.结果 化疗有效组肺癌 7 项抗体水平均低于无效组(P＜0.05).经ROC曲线分析证实,肺癌 7 项抗体(CAGE、GAGE7、GBU4-5、P53、PGP95、SOX2、MAGEA1)评估NSCLC患者化疗疗效的效能均较佳,曲线下面积分别为 0.861、0.769、0.778、0.786、0.793、0.842、0.833.预后不良组肺癌 7 项抗体水平均高于预后良好组(P＜0.05).经多因素Logistic回归分析证实,肺癌 7 项抗体为NSCLC患者预后不良的危险因素水平(OR＞1,P＜0.05).结论 肺癌 7 项抗体水平与NSCLC患者化疗效果及预后密切相关,随着肺癌 7 项抗体水平的升高,NSCLC患者化疗效果及预后越差. |
| Abstract_FL | Objective To study the relationship between seven antibody of lung cancer and the chemotherapy effect and prognosis of patients with non-small cell lung cancer(NSCLC).Methods A total of 42 patients with NSCLC admitted to Taihe County People's Hospital from June 2022 to December 2023 were selected.All subjects underwent 4 cycles of chemotherapy.They were divided into effective group(n=25)and non-effective group(n=17)according to the outcome of chemotherapy.The seven antibody of lung cancer were titrated and compared and the efficacy in evaluating chemotherapy was analyzed by receiver operating characteristic(ROC)curve.In addition,the subjects were divided into a good prognosis group(n=21)and a poor prognosis group(n=21)according to the difference in clinical outcomes.The seven antibody of lung cancer were titrated and compared between the two groups,and the relationship between the antibody level and the prognosis of NSCLC patients was determined by multivariate Logistic regression analysis.Results The an-tibody level in effective group was lower than that in the non-effective group(P＜0.05).ROC curve analysis confirmed that the level of CAGE,GAGE7,GBU4-5,P53,PGP95,SOX2 and MAGEA1 is significantly re-lated to better efficacy of chemotherapy and the areas under the curve were 0.861,0.769,0.778,0.786,0.793,0.842 and 0.833,respectively.The antibody level of lung cancer in poor prognosis group was higher than those in good prognosis group(P＜0.05).Multiple Logistic regression analysis confirmed that the seven antibody levels were the risk factors for poor prognosis in NSCLC patients(all OR value＞1,P＜0.05).Conclusions The level of seven antibody of lung cancer are negatively related to the chemotherapy effect and prognosis of NSCLC patients.With increase of the seven antibody level of lung cancer,prognosis of patients re-sulted from chemotherapy is worse. |
| Author | 杨连任 梁伟 张伟 张振 |
| AuthorAffiliation | 太和县人民医院 肿瘤放疗科,安徽 阜阳 236000%安徽医科大学第一附属医院 肿瘤放疗科 安徽合肥 230000 |
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| Author_FL | ZHANG Zhen LIANG Wei YANG Lianren ZHANG Wei |
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| Author_xml | – sequence: 1 fullname: 张伟 – sequence: 2 fullname: 张振 – sequence: 3 fullname: 杨连任 – sequence: 4 fullname: 梁伟 |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| DocumentTitle_FL | Association of seven antibody levels in lung cancer with chemotherapy effect and prognosis in patients with NSCLC |
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| Keywords | non-small cell lung cancer 预后转归 autoantibody chemotherapy effect 非小细胞肺癌 prognosis 自身抗体 化疗效果 |
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| Title | 肺癌7项抗体水平与NSCLC患者化疗效果及预后的关系 |
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