仿生印迹亲和分析技术研究进展

分子印迹是一种模拟生物分子特异性识别的仿生技术,通过制备分子印迹聚合物(MIPs),结合高特异性亲和分析方法所构建的仿生印迹亲和分析(Biomimetic imprinting affinity analysis,BIA)技术具有灵敏度高、耐受性强、专一性好以及成本低等优势,在食品安全检测、药物分析和环境污染监测等领域展现出良好的发展潜力.本文首先介绍了BIA识别界面的构建方法,包括本体聚合、电聚合和表面印迹法等,总结了近年来MIPs在放射标记亲和分析、酶标记亲和分析、荧光标记亲和分析、化学发光亲和分析和电化学免疫传感等不同分析方法中的研究和应用进展,最后讨论了该技术在实际应用中所面临的挑战和...

Full description

Saved in:
Bibliographic Details
Published in分析化学 Vol. 52; no. 6; pp. 763 - 777
Main Authors 李兆周, 韦玉花, 张孝冲, 陈秀金, 王耀, 牛华伟, 李芳, 高红丽, 于慧春, 袁云霞
Format Journal Article
LanguageChinese
Published 河南科技大学食品与生物工程学院,河南省食品绿色加工与质量安全控制国际联合实验室,洛阳471000 2024
Subjects
Molecularly imprinted
Affinity analysis
分子印迹
亲和分析
仿生
Review
评述
Biomimetic technology
Online AccessGet full text
ISSN0253-3820
DOI10.19756/j.issn.0253-3820.231273

Cover

Abstract 分子印迹是一种模拟生物分子特异性识别的仿生技术,通过制备分子印迹聚合物(MIPs),结合高特异性亲和分析方法所构建的仿生印迹亲和分析(Biomimetic imprinting affinity analysis,BIA)技术具有灵敏度高、耐受性强、专一性好以及成本低等优势,在食品安全检测、药物分析和环境污染监测等领域展现出良好的发展潜力.本文首先介绍了BIA识别界面的构建方法,包括本体聚合、电聚合和表面印迹法等,总结了近年来MIPs在放射标记亲和分析、酶标记亲和分析、荧光标记亲和分析、化学发光亲和分析和电化学免疫传感等不同分析方法中的研究和应用进展,最后讨论了该技术在实际应用中所面临的挑战和未来的发展趋势.
AbstractList 分子印迹是一种模拟生物分子特异性识别的仿生技术,通过制备分子印迹聚合物(MIPs),结合高特异性亲和分析方法所构建的仿生印迹亲和分析(Biomimetic imprinting affinity analysis,BIA)技术具有灵敏度高、耐受性强、专一性好以及成本低等优势,在食品安全检测、药物分析和环境污染监测等领域展现出良好的发展潜力.本文首先介绍了BIA识别界面的构建方法,包括本体聚合、电聚合和表面印迹法等,总结了近年来MIPs在放射标记亲和分析、酶标记亲和分析、荧光标记亲和分析、化学发光亲和分析和电化学免疫传感等不同分析方法中的研究和应用进展,最后讨论了该技术在实际应用中所面临的挑战和未来的发展趋势.
Abstract_FL Molecular imprinting is a biomimetic technique that simulates the specific recognition of biological macromolecules such as antibody. Based on molecular imprinting and high-specificity affinity analysis,the biomimetic imprinting affinity analysis (BIA) possesses many advantages such as high sensitivity,strong tolerance,good specificity and low cost,and thus,it has shown excellent prospects in food safety detection,pharmaceutical analysis and environmental pollution monitoring. In this review,the construction methods of recognition interfaces for BIA were summarized,including bulk polymerization,electro-polymerization and surface molecular imprinting. The application of molecularly imprinted polymers in different analysis methods,such as radiolabeled affinity analysis,enzyme-labeled affinity analysis,fluorescence-labeled affinity analysis,chemiluminescence affinity analysis and electrochemical immunosensor was mainly discussed. Furthermore,the challenges and future development trends of BIA in practical application were elucidated. This review might provide new reference ideas and technical supports for the further development of BIA technique.
Author 袁云霞
张孝冲
韦玉花
高红丽
李芳
陈秀金
王耀
牛华伟
李兆周
于慧春
AuthorAffiliation 河南科技大学食品与生物工程学院,河南省食品绿色加工与质量安全控制国际联合实验室,洛阳471000
AuthorAffiliation_xml – name: 河南科技大学食品与生物工程学院,河南省食品绿色加工与质量安全控制国际联合实验室,洛阳471000
Author_FL GAO Hong-Li
WEI Yu-Hua
YUAN Yun-Xia
LI Zhao-Zhou
YU Hui-Chun
CHEN Xiu-Jin
WANG Yao
LI Fang
NIU Hua-Wei
ZHANG Xiao-Chong
Author_FL_xml – sequence: 1
  fullname: LI Zhao-Zhou
– sequence: 2
  fullname: WEI Yu-Hua
– sequence: 3
  fullname: ZHANG Xiao-Chong
– sequence: 4
  fullname: CHEN Xiu-Jin
– sequence: 5
  fullname: WANG Yao
– sequence: 6
  fullname: NIU Hua-Wei
– sequence: 7
  fullname: LI Fang
– sequence: 8
  fullname: GAO Hong-Li
– sequence: 9
  fullname: YU Hui-Chun
– sequence: 10
  fullname: YUAN Yun-Xia
Author_xml – sequence: 1
  fullname: 李兆周
– sequence: 2
  fullname: 韦玉花
– sequence: 3
  fullname: 张孝冲
– sequence: 4
  fullname: 陈秀金
– sequence: 5
  fullname: 王耀
– sequence: 6
  fullname: 牛华伟
– sequence: 7
  fullname: 李芳
– sequence: 8
  fullname: 高红丽
– sequence: 9
  fullname: 于慧春
– sequence: 10
  fullname: 袁云霞
BookMark eNrjYmDJy89LZWBQMDTQM7Q0NzXTz9LLLC7O0zMwMjXWNbYwMtAzMjY0MjdmYeCEC3EwcBUXZxkYGJubmptzMmg92b3_-ZT5T3s3vNi_88muTU8n9TztaHs2b8KzroZnc9Y_XzDl-cptL_bPfrpxKg8Da1piTnEqL5TmZlB1cw1x9tAtT8xLS8xLj8_KLy3KA8rEp1VkVBgZGJkYmBkYGBkTqw4A_P9Jqw
ContentType Journal Article
Copyright Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 2B.
4A8
92I
93N
PSX
TCJ
DOI 10.19756/j.issn.0253-3820.231273
DatabaseName Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
DocumentTitle_FL Research Progress of Biomimetic Imprinting Affinity Analysis Technique
EndPage 777
ExternalDocumentID fxhx202406002
GroupedDBID --K
--M
-02
-0B
-SB
-S~
.5D
.~1
0R~
188
1B1
1~.
1~5
29B
2B.
4.4
457
4A8
4G.
5GY
5VR
5VS
5XA
5XC
7-5
71M
8P~
8RM
92E
92I
92L
92M
93N
9D9
9DB
AAEDT
AAEDW
AAIKJ
AAITT
AAKOC
AALRI
AAOAW
AAQFI
AARLI
AATTM
AAXKI
AAXUO
AAYWO
ABFNM
ABJNI
ABMAC
ABWVN
ABXDB
ACDAQ
ACGFS
ACNNM
ACRLP
ACRPL
ADBBV
ADECG
ADEZE
ADMUD
ADNMO
ADVLN
AEBSH
AEIPS
AEKER
AENEX
AFJKZ
AFTJW
AFUIB
AFXIZ
AFZHZ
AGCQF
AGHFR
AGRNS
AGUBO
AGYEJ
AIEXJ
AIIUN
AIKHN
AITUG
AJSZI
AKRWK
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ANKPU
APXCP
AXJTR
BBR
BKOJK
BLXMC
BNPGV
CAJEB
CCEZO
CDRFL
CDYEO
CJPJV
CQIGP
CS3
CW7
CW9
DU5
EBS
EFJIC
EJD
EO9
EP2
EP3
FA0
FDB
FEDTE
FIRID
FLBIZ
FNPLU
FYGXN
GBLVA
HVGLF
HZ~
J.9
J1W
JUIAU
KOM
M41
MO0
M~T
N9A
O-L
O9-
OAUVE
OZT
P-8
P-9
P2P
PB1
PB6
PC.
PSX
Q--
Q38
R-B
ROL
RT2
S..
SDF
SDG
SES
SPC
SPCBC
SSH
SSK
SSZ
T5K
T8R
TCJ
TGP
U1F
U1G
U5B
U5L
UY8
UZ4
W94
~G-
~LN
~WA
ID FETCH-wanfang_journals_fxhx2024060023
ISSN 0253-3820
IngestDate Thu May 29 04:00:24 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 6
Keywords Molecularly imprinted
Affinity analysis
分子印迹
亲和分析
仿生
Review
评述
Biomimetic technology
Language Chinese
LinkModel OpenURL
MergedId FETCHMERGED-wanfang_journals_fxhx2024060023
ParticipantIDs wanfang_journals_fxhx202406002
PublicationCentury 2000
PublicationDate 2024
PublicationDateYYYYMMDD 2024-01-01
PublicationDate_xml – year: 2024
  text: 2024
PublicationDecade 2020
PublicationTitle 分析化学
PublicationTitle_FL Chinese Journal of Analytical Chemistry
PublicationYear 2024
Publisher 河南科技大学食品与生物工程学院,河南省食品绿色加工与质量安全控制国际联合实验室,洛阳471000
Publisher_xml – name: 河南科技大学食品与生物工程学院,河南省食品绿色加工与质量安全控制国际联合实验室,洛阳471000
SSID ssj0037577
ssib048394981
ssib007686865
Score 4.7709603
Snippet 分子印迹是一种模拟生物分子特异性识别的仿生技术,通过制备分子印迹聚合物(MIPs),结合高特异性亲和分析方法所构建的仿生印迹亲和分析(Biomimetic imprinting affinity...
SourceID wanfang
SourceType Aggregation Database
StartPage 763
Title 仿生印迹亲和分析技术研究进展
URI https://d.wanfangdata.com.cn/periodical/fxhx202406002
Volume 52
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07bxNBED5FpoAG8RQEiCjYBunM3d4-y137oggJqiCli-4cm1RGAkeKUiAqhBBICIUKBLRUPAokoPCfie38DGZ272XFPBtrvTf3zTffrG_3zru3QXCtl-W5AoZhxhMRsoHWYSb7WyHNFctwG1WucL3zrdti7Q67ucE3llpRY9bSzihv9_YWriv5n6xCHeQVV8n-Q2YrUKiAMuQXPiHD8PlXOSYpI9YSu0pSSTQjGgqcqC6xEUkV1lvtbAyxFA9pSlTH2SiiBEkF0SnRERaUwUkPWNMhxgGaCDGxoIkVBaC2eLqNid-0shzXLsLk6EsLLJguMdUjQGfSJSp1JtydBNRiYlRtojEYI9A9GCqN7oGijWsToNFBkh4fEFOHZekcikZeGIR08cFXkCpuPuyg9WNOpAZK2aTQUcviVGBXawT-GFaWgSGqSQr1dQKDcye6ciFWiZEYBUiJvAGTO2SwsXM4wNdQaPeLmUBuEPyoO1m2A4VefLKBrVencFdRgkQydO3FUA7HeJFdQvCQQEsfI-hnfYrARbcUlTtfsWsiHPONMjscSD8yNEVTgxqQq4iIuQYECICZMHznU9ToiihPwkTRqNlvctq4PjQ7wbLL8uMp6bfpOdJVa8mF66vRQ7vy0IYbDiqTenhSTRod7G7vYpuIhHt77DEqZYyTeNsP6x4Kbp6Fqv-3ZzD8Z1pVk74Syd1erJW3Ym4fcrnxCyZuNd9wkA3vNgae66eCk8Ud41Xjf_6ng6W97TPB8U65UePZ4PrBj_Fs_93k-afD8beD718mL59Nnjyevn0xffpo-ubj7P3-7MPXw_HryedX5wKymq531sLC12ZxmXmwORd2cj5oDe8N-xeAt4gGmvMsU31cTB7rOIm3ekr2oxxf6te7GKz8Hmv5TwaXghNY9g8cLwet0f2d_hUYgo_yFaf6TyeclLU
linkProvider Elsevier
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E4%BB%BF%E7%94%9F%E5%8D%B0%E8%BF%B9%E4%BA%B2%E5%92%8C%E5%88%86%E6%9E%90%E6%8A%80%E6%9C%AF%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95&rft.jtitle=%E5%88%86%E6%9E%90%E5%8C%96%E5%AD%A6&rft.au=%E6%9D%8E%E5%85%86%E5%91%A8&rft.au=%E9%9F%A6%E7%8E%89%E8%8A%B1&rft.au=%E5%BC%A0%E5%AD%9D%E5%86%B2&rft.au=%E9%99%88%E7%A7%80%E9%87%91&rft.date=2024&rft.pub=%E6%B2%B3%E5%8D%97%E7%A7%91%E6%8A%80%E5%A4%A7%E5%AD%A6%E9%A3%9F%E5%93%81%E4%B8%8E%E7%94%9F%E7%89%A9%E5%B7%A5%E7%A8%8B%E5%AD%A6%E9%99%A2%2C%E6%B2%B3%E5%8D%97%E7%9C%81%E9%A3%9F%E5%93%81%E7%BB%BF%E8%89%B2%E5%8A%A0%E5%B7%A5%E4%B8%8E%E8%B4%A8%E9%87%8F%E5%AE%89%E5%85%A8%E6%8E%A7%E5%88%B6%E5%9B%BD%E9%99%85%E8%81%94%E5%90%88%E5%AE%9E%E9%AA%8C%E5%AE%A4%2C%E6%B4%9B%E9%98%B3471000&rft.issn=0253-3820&rft.volume=52&rft.issue=6&rft.spage=763&rft.epage=777&rft_id=info:doi/10.19756%2Fj.issn.0253-3820.231273&rft.externalDocID=fxhx202406002
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Ffxhx%2Ffxhx.jpg