利用非共价复合物实现对布洛芬分子的手性分析
手性药物的检测对于深入了解药物作用机理具有十分重要的意义.布洛芬(Ibuprofen)是常用的临床消炎药物,具有R型和S型两种构型,但其消炎作用却几乎全部由S-布洛芬所提供.本研究建立了一种区分布洛芬手性的方法,将布洛芬对映体与γ-环糊精及BaCl2混合,得到系列非共价复合物,利用捕集离子淌度质谱(Trapped ion mobility spectrometry-time-of-flight mass spectrometry,TIMS-TOF MS)测量各物质的离子淌度(Ion moboility).采用TIMS-TOF MS成功分离了非对映体离子[γ-CD+R-Ibuprofen+Ba(...
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| Published in | 分析化学 Vol. 49; no. 1; pp. 95 - 102 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
复旦大学化学系,上海200438%上海医药工业研究院,上海200040%宁波大学材料科学与化学工程学院,质谱技术与应用研究院,宁波315211
2021
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| Abstract | 手性药物的检测对于深入了解药物作用机理具有十分重要的意义.布洛芬(Ibuprofen)是常用的临床消炎药物,具有R型和S型两种构型,但其消炎作用却几乎全部由S-布洛芬所提供.本研究建立了一种区分布洛芬手性的方法,将布洛芬对映体与γ-环糊精及BaCl2混合,得到系列非共价复合物,利用捕集离子淌度质谱(Trapped ion mobility spectrometry-time-of-flight mass spectrometry,TIMS-TOF MS)测量各物质的离子淌度(Ion moboility).采用TIMS-TOF MS成功分离了非对映体离子[γ-CD+R-Ibuprofen+Ba(BaCl)-H]2+与[γ-CD+S-Ibuprofen+Ba(BaCl)-H]2+,碰撞截面的差值高达0.07 nm2.此外,实验结果表明,一系列[γ-CD+S-Ibuprofen+Ba(BaCl)-H]2+的离子淌度谱峰强度分数与其摩尔分数呈线性关系.本方法无需对样品分子进行前处理或化学衍生化,可以快速、高效地分析手性分子. |
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| AbstractList | 手性药物的检测对于深入了解药物作用机理具有十分重要的意义.布洛芬(Ibuprofen)是常用的临床消炎药物,具有R型和S型两种构型,但其消炎作用却几乎全部由S-布洛芬所提供.本研究建立了一种区分布洛芬手性的方法,将布洛芬对映体与γ-环糊精及BaCl2混合,得到系列非共价复合物,利用捕集离子淌度质谱(Trapped ion mobility spectrometry-time-of-flight mass spectrometry,TIMS-TOF MS)测量各物质的离子淌度(Ion moboility).采用TIMS-TOF MS成功分离了非对映体离子[γ-CD+R-Ibuprofen+Ba(BaCl)-H]2+与[γ-CD+S-Ibuprofen+Ba(BaCl)-H]2+,碰撞截面的差值高达0.07 nm2.此外,实验结果表明,一系列[γ-CD+S-Ibuprofen+Ba(BaCl)-H]2+的离子淌度谱峰强度分数与其摩尔分数呈线性关系.本方法无需对样品分子进行前处理或化学衍生化,可以快速、高效地分析手性分子. |
| Author | 周鸣飞 余绍宁 周爱南 李建其 古连城 陈新 丁传凡 吴芳玲 |
| AuthorAffiliation | 复旦大学化学系,上海200438%上海医药工业研究院,上海200040%宁波大学材料科学与化学工程学院,质谱技术与应用研究院,宁波315211 |
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| Author_FL | ZHOU Ai-Nan CHEN Xin YU Shao-Ning ZHOU Ming-Fei DING Chuan-Fan GU Lian-Cheng LI Jian-Qi WU Fang-Ling |
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| DOI | 10.19756/j.issn.0253-3820.201477 |
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| DocumentTitle_FL | Chiral Analysis of Ibuprofen through Non-covalent Complexes |
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| Keywords | 手性分析 非共价复合物 布洛芬 氯化钡 捕集离子淌度质谱 γ-环糊精 |
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| Publisher | 复旦大学化学系,上海200438%上海医药工业研究院,上海200040%宁波大学材料科学与化学工程学院,质谱技术与应用研究院,宁波315211 |
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| Snippet | 手性药物的检测对于深入了解药物作用机理具有十分重要的意义.布洛芬(Ibuprofen)是常用的临床消炎药物,具有R型和S型两种构型,但其消炎作用却几乎全部由S-布洛芬所提供.本研究建立了一种区分布洛芬手性的方法,将布洛芬对映体与γ-环糊精及BaCl2混合,得到系列非共价复合物,利用捕集离子淌度质谱(Trapped... |
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| Title | 利用非共价复合物实现对布洛芬分子的手性分析 |
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