PPARa governs glycerol metabolism

• Published in: The Journal of clinical investigation Vol. 114; no. 1
• Main Authors: Patsouris, D.A, Mandard, S.J, Voshol, P.J, Escher, P, Tan, N.S, Havekes, L.M, Koenig, W, März, W, Müller, M.R, Kersten, A.H
• Format: Journal Article
• Published: 2004
• Subjects: (ppar)-alpha activation; activated receptor-gamma; deficient mice; fasting response; free fatty-acid; gluconeogenesis; hepatic glucose-production; improves insulin sensitivity; null mice; oletf rats

Glycerol, a product of adipose tissue lipolysis, is an important substrate for hepatic glucose synthesis. However, little is known about the regulation of hepatic glycerol metabolism. Here we show that several genes involved in the hepatic metabolism of glycerol, i.e., cytosolic and mitochondrial gl...