Method for the suppression of viral growth

123 4 33A method for suppressing undesired viral growth in a host which comprises administering to the host an effective amount of a compound of the formula: wherein R, R, Rand Rare independently selected from the group consisting of HO-, CHO- and CH(C═O) O-. The method is exemplified by inhibiting...

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Main Authors Huang, Ru Chih C, Gnabre, John N
Format Patent
LanguageEnglish
Published 15.04.2008
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Abstract 123 4 33A method for suppressing undesired viral growth in a host which comprises administering to the host an effective amount of a compound of the formula: wherein R, R, Rand Rare independently selected from the group consisting of HO-, CHO- and CH(C═O) O-. The method is exemplified by inhibiting Tat transactivation of a lentivirus and in suppressing Herpes simplex virus.
AbstractList 123 4 33A method for suppressing undesired viral growth in a host which comprises administering to the host an effective amount of a compound of the formula: wherein R, R, Rand Rare independently selected from the group consisting of HO-, CHO- and CH(C═O) O-. The method is exemplified by inhibiting Tat transactivation of a lentivirus and in suppressing Herpes simplex virus.
Author Huang, Ru Chih C
Gnabre, John N
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References Huang et al. (6777444) 20040800
Huang et al. (6214874) 20010400
Neiss et al. (5276060) 19940100
Russell T. Jordan and Larry M. Allen, "Neoplasm Inhibitors Comprising Metal Salts and Phenol Derivatives," Chemical Abstracts, vol. 111, No. 3, Jul. 17, 1989, p. 64.
Gisvold et al., Ligans from Larrea divaricata, Journal of Pharmecutical Sciences, 1974, vol. 63, No. 12, pp. 1905-1907.
Moeller et al. (4425327) 19840100
Orth et al. (5342930) 19940800
Huang et al. (5663209) 19970900
Wang et al. (5965616) 19991000
Huang et al. (6417234) 20020700
Perry et al, Synthesis of Lignans, I. Nordihydroguaiaretic Acid 1, J. Org. Chem, 1972, vol. 37, No. 26, p. 4371-4376.
Altieri (6245523) 20010600
Jordan (4880637) 19891100
Chemical Abstracts No. 101816r, vol. 110, No. 11, issued Mar. 13, 1989, Jordan, "Compositions Containing Catecholic Butanes and Zinc For Treating Solid Tumors".
Staal et al., Antioxidants Inhibits Stimulation of HIV Transcription, Aids Research and Human Retroviruses, 1993, vol. 9, No. 4, pp. 299-306.
Jordan (4774229) 19880900
Sinnott et al. (5837252) 19981100
Clum et al. (5559149) 19960900
Mulshine et al. (6071949) 20000600
Grabre et al., Inhibition of Human Immunodeficency Virus type 1 transcription and replication by DNA sequence-s-elective plant lignans, Proc. Natl. Acad. Sci. USA, 1995, vol. 92, pp. 11239-11243.
Ru Chih C. Huang et al., "Regulation of HIV Promoter Activities in Human Embryonal Carcinoma Cells, Ntera-2", Gene Regulation and Aids, T. S. Papas, ed. 1989, pp. 147-160.
Weislow et al., New Soluble-Formazan Assay for HIV-1 Cytopathic Effects: Application to High-Flux Screening of Symthetic and Natural Products for AIDS-Antiviral Activity, Journal of the National Cancer Institute, 1989, vol. 81, No. 8, pp. 577-586.
Giza et al., A self-inducing runaway-replication plasmid expression system utilizing the Ro protein, Elsevier Science Publishers B.V. (Biomedical Division), Gene 78, 1989, pp. 73-84.
Chemical Abstracts No. 118499d vol. 118499d vol. 112, No. 13, issued Mar. 26, 1990, Rao, "Regioselective Cleavage of the Methylendioxy Group: Conversion of(-)-Austrobailignan-5 To (-)-Dihydroguairetic Acid."
Shantha (5195965) 19930300
Gnabre et al., Characterization of Anti-HIV Lignans from Larrea tridentateTetrahedrom, 1995, vol. 51, No. 45, pp. 12203-12210.
Khandwala et al. (5827898) 19981000
Paul E. Giza and Ru Chih C. Huang, "A Self-Inducing Runaway-Replication Plasmid Expression System Utilizing the RPO Protein," Gene, 78(1989) pp. 73-84.
Gnabre et al., Isolation of anti-HIV-1 lignans from Larrea tridentateounter-current chromatography, Journal of Chromatography A., 719, 1996, pp. 353-364.
Neiss et al. (5008294) 19910400
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