Process for obtaining botulinum neurotoxin
botulinum Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield neurotoxin for research, therapeutic and cosmetic use.
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| Format | Patent |
| Language | English |
| Published |
04.12.2012
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| Online Access | Get full text |
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| Abstract | botulinum Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield neurotoxin for research, therapeutic and cosmetic use. |
|---|---|
| AbstractList | botulinum Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield neurotoxin for research, therapeutic and cosmetic use. |
| Author | Ahmad, Wajdie M Patel, Hemant A Bates, Ronald C Ton, Jennifer L |
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| References | Donovan (7445914) 20081100 Prabakaran, S., et al. "Botulinum neurotoxin types B and E: Purification, limited proteolysis by endoproteinase Glu-C and Pepsin, and comparison of their indentified cleaved sites relative to the three-dimensional structure of type A neurotoxin." Toxicon 39 (2001): 1515-1531. Luo (2009/0123497) 20090500 Miwa, Norinaga, et al. International Journal of Food Microbiology 49 (1999): 103-106. Weatherly, G., et al. "Initial purification of recombinant botulinum neurotoxin fragments for pharmaceutical production using hydrophobic charge induction chromatography." Journal of Chromatography A 952 (2002): 99-110. Thompson (4401683) 19830800 Gressler, F., et al. "Production and purification of Clostridium botulinum type C and D neurotoxin." FEMS Immunology and Medical Microbiology 24 (1999): 361-367. Johnson, E., et al. "Clostridium botulinum and its neurotoxins: a metabolic and cellular perspective." Toxicon 39 (2001): 1703-1722. (WO 2005/035749) 20050400 (WO 96/05222) 19960200 Heenan, C.N., et al. Lehensm.-Wiss. U.-Technol. 35 (2002): 171-176. (WO 01/58472) 20010200 Ton et al. (8129139) 20120300 (WO 98/54296) 19980500 Kohl, A., et al. "Comparison of the effect of botulinum toxin A (BOTOX®) with the highly-purified neurotoxin (NT201) in the extensor digitorum brevis muscle test." Movement Disorders 15(Suppl 3) (2000): 165. Ton et al. (2012/0108792) 20120500 Wang et al. (7160699) 20070100 Siegel, L.S. "Fermentation kinetics of botulinum toxin production (types A, B and E)." Biomedical aspects of botulism, New York: Academic Press 1981: 121-128. Oguma (6818409) 20041100 Naumann, M., et al. "Botulinum toxin type A in the treatment of focal, axillary and palmar hyperhidrosis and other hyperhidrotic conditions." European Journal of Neurology 6(Suppl 4) (1999): S111-S115. Schantz, E.J., et al., Lewis, G.E. "Use of Chrystalline type A botulinum toxin in medical research." Biomedical Aspects of Botulism, Academic Press, Inc., George E. Lewis, Jr., Ed., 1981: 143-150. (WO 01/36655) 20011000 Bedu-Addo, F., et al. "Use of Biophysical characterization in preformulation development of a heavy-chain fragment of botulinum serotype B: Evaluation of Suitable Purification process conditions." Pharmaceutical Research 21.8 (2004): 1353:1361. Luo (7452697) 20081100 Schantz. E.J. et al. "Properties and use of botulinum toxin and other microbial neurotoxins in medicine. " Microbiological Reviews Mar. 1992: 80-99. Whitmer, M.E. et al. "Development of improved defined media for Clostridium botulinum serotypes A, B and E." Applied and Environmental Microbiology 54.3 (Mar. 1988): 753-759. Donovan (7148041) 20061200 Demain et al. (2004/0235139) 20041100 Johnson, S., et a. "Scale-up of the fermentation and purification of the recombinant heavy chain fragment C of botulinum neurotoxin serotype F, expressed in Pichia pastoris." Protein Expression and Purification 32 (2003): 1-9. Schiefer-Ullrich, H., et al. "Comparative studies on physiology and taxonomy of obligatory purinolytic clostridia." Archives of Microbiology 138 (1984): 345-353. Luo (2009/0124790) 20090500 Siegel, L.S. "Toxin production by Clostridium botulinum type A under various fermentation conditions." Applied and Environmental Microbiology Oct. 1979: 606-611. Wang (2008/0223103) 20080900 Byrne, M., et al., Fermentation, Purification and Efficacy of a Recombinant Vaccine Candidate Against Botulinum Neurotoxin Type F form Pichia pastoris, Protein Expression and Purification, 2000, 18, pp. 327-337. Karasawa, T., et al. "A defined growth medium for Clostridium difficle." Microbiology 141 (1995): 371-375. Huhtanen, C.N. "Some observations on a perigo-type inhibition of Clostridium botulinum in a simplified medium." Journal of Milk Food Technology 38.12 (Dec. 1975): 761-763. Wang et al. (7560251) 20090700 Porfirio, Z., et al. "Specific peptides of casein pancreatic digestion enhance the production of tetanus toxin." Journal of Applied Microbiology 83 (1997): 678-684. Kozaki, H., et al. "Immunological characterization of papain-induced fragments of Clostridium botulinum type A neurotoxin and the interaction of the fragments with brain synaptosomes." Infection and Immunity 57.9 (1989): 2634-2639. U.S. Appl. No. 12/098,896, filed Apr. 7, 2008, Hui Xiang. Hunt (2003/0118598) 20030600 Simpson, L. S. "Isolation and Characterization of the Botulinum Neurotoxins", Methods in Enzymology, Preparation of Toxins, vol. 165; (1988): 76-85. Schantz, E.J. et al., J. Jankovic ed. "Preparation and characterization of botulinum toxin type A for human treatment." Neurological Disease and Therapy. Therapy with Botulinum Toxin 25 (1994): 41-49. Donovan (2009/0022763) 20090100 Byrne, M., et al. "Purification, potency, and efficacy of the botulinum type A binding Domain from Pichia pastoris as a recombinant vaccine candidate." Infection and Immunity 66.10 (1998): 4817-4822. Donovan (7189541) 20070300 Holdeman, L., et al. "A study of the nutritional requirements and toxin production of Clostridium botulinum Type F." Canadian Journal of Microbiology, 11 (1965): 1009-1019. Ragona, Rosario Marchese, et al. "Management of Parotid Sialocele with botulinum toxin." The Laryngoscope 109 (Aug. 1999): 1344-1346. Tse, et al. European Journal of Ciochemistry 122 (1982): 493-500. Young-Perkins, et al. Journal of Food Science 52 (1987): 1084-1088. Gimenez, J., et al. "Simplified purification method for Clostridium botulinum type E toxin." Applied and Enviromental Microbiology 53.12 (Dec. 1987): 2827-2830. Demain et al. (6558926) 20030500 Mueller, J.H., et al. "Variable factors influencing the product of tetanus toxin." Journal of Bacteriology Mar. 1954, 67.3: 271-277. Ozutsumi, K., et al. "Rapid, simplified method for production and purification of tetanus toxin." Applied and Environmental Microbiology 49.4 (Apr. 1985): 939-943. Li, Y., et al. "Expression and characterization of the heavy chain of tetanus toxin: reconstitution of the fully-recombinant dichain protein in active form."0 Journal of Biochemistry (Tokyo) 125.6 (Jun. 1999): 1200-1208. Condrad (7354470) 20080400 (WO 94/09155) 19940400 Chen, F., et al. "Biophysical characterization of the stability of the 150-kilodalton botulinum toxin, the nontoxic component and the 900-kilodalton botulinum toxin complex species." Infection and Immunity 66.6 (Jun. 1998): 2420-2425. (WO 01/05997) 20010700 Coligan, John E., et al., Eds. "Chp. 1:1-88, Strategies of protein purification and characterization." Current Protocols in Protein Science, Front Matter Aug. 2003. Lungdahl, L.G., et al. "Working with anaerobic bacteria." Manual of Industrial Microbiology and Biotechnology 1986, Chaper 8:84-96. |
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