Inhibitors of histone deacetylase

1234 This invention comprises the novel compounds of formula (I) wherein n, t, R, R, R, R, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

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Main Authors Angibaud, Patrick René, Pilatte, Isabelle Noëlle Constance, Van Brandt, Sven Franciscus Anna, Roux, Bruno, Ten Holte, Peter, Verdonck, Marc Gustaaf Celine, Meerpoel, Lieven, Dyatkin, Alexey Borisovich
Format Patent
LanguageEnglish
Published 18.09.2012
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Abstract 1234 This invention comprises the novel compounds of formula (I) wherein n, t, R, R, R, R, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
AbstractList 1234 This invention comprises the novel compounds of formula (I) wherein n, t, R, R, R, R, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
Author Ten Holte, Peter
Meerpoel, Lieven
Roux, Bruno
Verdonck, Marc Gustaaf Celine
Pilatte, Isabelle Noëlle Constance
Dyatkin, Alexey Borisovich
Van Brandt, Sven Franciscus Anna
Angibaud, Patrick René
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  givenname: Sven Franciscus Anna
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References Acharya et al., "Rational Development of Histone Deacetylase Inhibitors as Anticancer Agents: A Review," Molecular Pharmacology, 2005; 68(4):917-932.
Tomcufcik et al. (3331843) 19670700
(WO-00/71516) 20001100
Gorrod et al, "The Metabolism of N-Ethyl-N-methylaniline by Rabbit Liver Microsomes: The Measurement of Metabolites by Gas-Liquid Chromatography," Xenobiotica, 1975; 5(8):453-462.
(2 518 950) 20050200
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,784 dated Apr. 6, 2007, 13 pages.
Angibaud et al. (8101616) 20120100
Walsh et al., "Synthesis and Antiallergy Activity of N-[2-(Dimethylamino)ethyl]-4-aryl-1-piperazinecarboxamide Derivatives," J. Med. Chemistry, 1990; 33:2028-2032.
(WO-2005/030704) 20050400
In the U.S. Patent and Trademark Office U.S. Appl. No. 12/539,682 Non-Final Office Action dated Sep. 30, 2009, 13 pages.
(WO 2006/136553) 20061200
Van Emelen et al. (2010/0010004) 20100100
Irikura et al., "Absorption, Excretion, and Metabolism of 1-(p-aminobenzoyl)-4-(3, 4, 5-trimethoxybenzamido)piperidine (KU-55)," Pharmacometrics, 1973; 7(7):985-990. (With English-language Abstract).
Asberom et al. (5952349) 19990900
Sausville et al., "Contributions of Human Tumor Xenografts to Anticancer Drug Development," American Association for Cancer Research, 2006; 66(7):3351-3354.
(WO-2004/071400) 20040800
Dankwardt, et al., "Solid Phase Synthesis of Aryl and Benzylpiperazines and their Applications in Combinatorial Chemistry," Tetrahedron Letters, 1995; 36(28):4923-4926.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/160,156 dated Sep. 29, 2009, 13 pages.
Arts et al. (2009/0270419) 20091000
Angibaud et al. (2009/0170836) 20090700
(WO-2004/092115) 20041000
In the U. S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,084 dated Jul. 22, 2008, 5 pages.
Van Emelen et al. (2010/0048588) 20100200
(WO-2004/087693) 20041000
In the U.S. Patent and Trademark Office U.S. Appl. No. 11/914,208 Non-Final Office Action dated Mar. 10, 2011, 5 pages.
Van Brandt et al. (7947830) 20110500
Mizuchi et al. (5147876) 19920900
(1 525 199) 20050400
International Search Report from PCT/EP07/50374 dated Mar. 12, 2007, 4 pages.
Angibaud et al. (7888360) 20110200
Chou et al., "Chemotherapeutic Synergism, Potentiation and Antagonism," Encyclopedia of Human Biology, 1991; 2:371-379.
Hideshima et al., "Small-Molecule Inhibition of Proteasome and Aggresome Function Induces Synergistic Antitumor Activity in Multiple Myeloma," PNAS, 2005; 102(24):8567-8572.
(0188094) 19860700
Miura et al. (5025012) 19910600
Van Emelen et al. (8071615) 20111200
Berger et al. (3966743) 19760600
Pei Xin-Yan et al., "Synergistic Induction of Oxidative Injury and Apoptosis in Human Multiple Myeloma Cells by the Proteasome Inhibitor Bortezomib and Histone Deacetylase Inhibitors," Clinical Cancer Research, 2004; 10:3839-3852.
(WO-98/05335) 19980200
(WO-2005/086898) 20050900
Khuthier et al., "Studies of Tertiary Amine Oxides, 9.1 Thermal Rearrangement of 1-(4-Substituted-phenyl)piperidine N-Oxides to the Corresponding N-Hydroxlmines," J. Org. Chem, 1987: 52:1710-1713.
(WO 01/70675) 20010900
Marconnet-Decrane et al. (2009/0143401) 20090600
Priepke et al. (2004/0248897) 20041200
International Search Report from PCT/EP03/02513 dated May 22, 2003, 2 pages.
Golub et al., "Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring," Science, 1999; 286:531-537.
Bertino et al., "Principles of Cancer," Cecil's Textbook of Medicine, 2000; 21st Edition, vol. 1:1060-1074.
(WO-00/43394) 20000700
Calabresi P. and Chabner BA, "Section IX Chemotherapy of Neoplastic Diseases-Introduction," Goodmans & Gilman's The Pharmacological Basis of Therapeutics, 10th ed., 2001, Hardman JG, Limbird LE, and Gilman AG, Eds, McGraw-Hill, New York 2001, 1381-1388 (1381, 1383-1385, 1388 provided).
(WO 98/55449) 19981200
In the U.S. Patent and Trademark Office U.S. Appl. No. 10/507,708 Non-Final Office Action dated Nov. 23, 2005, 15 pages.
Singh et al. (5342846) 19940800
(WO-2004/082638) 20040900
(WO-2005/092899) 20051000
Van Emelen et al., "Discovery of a Novel Class of Aromatic Hydroxamic Acids as Potent HDAC Inhibitors," AACR-NCI-Eortc International Conference on Molecular Targets and Cancer Therapeutics, 2003, XP009095813.
International Search Report from PCT/EP03/02512 dated Jun. 30, 2003, 4 pages.
(WO-97/23216) 19970700
Yokoyama et al., CAPLUS Abstract 105:226622 (1986).
Pasternak et al., "Potent, orally bioavailable somoatostatin agonists; good absorption achieved by urea backbone cyclization," Bioorganic and Medicinal Chemistry Letters 9, 1999; 9:491-496.
(1 485 365) 20080500
Van Emelen et al. (2010/0240639) 20100900
(WO-2005/030705) 20050400
(WO-02/18335) 20020300
Chen et al., "A Short and General Approach to the Synthesis of Styryllactones: (+)-Goniodiol, its Acetates and β-Trifluoromethyl Derivative, (+)-7-epi-Goniodiol and (+)-9-Deoxygoniopypyrone," SYNLETT, 2002; 8:1265-1268.
(WO 03/076430) 20030900
(WO-94/25437) 19941100
Van Emelen et al. (7704998) 20100400
Moradei et al. (2008/0132459) 20080600
Sutheesophon et al., "Histone Deacetylase Inhibitor Despsipeptides (FK228) Induces Apoptosis in Leukemic Cells by Facilitating Mitochondrial Translocation of Bax, Which is Enhanced by the Proteasome Inhibitor Bortezomib," ACTA Haematologica, 2006; 115:78-90.
(1 492 534) 20080600
In the U. S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,785 dated Jul. 19, 2007, 16 pages.
In the U. S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,784 dated Feb. 13, 2008, 5 pages.
In the U.S. Patent and Trademark Office U.S. Appl. No. 12/160,124 Non-Final Office Action dated Mar. 25, 2011, 12 pages.
Verdonck et al. (2009/0124646) 20090500
(WO-02/00651) 20020100
Bali et al., "Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90," Journal of Biological Chemistry, 2005, 280(29):26729-26734.
(WO-2004/072047) 20040800
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/160,221 dated Jan. 19, 2010, 7 pages.
Finnin et al., "Sturctures of histone deacetylase homologue bound to the TSA and SAHA inhibitors," Nature, 1999, pp. 188-193, vol. 401.
(WO-2004/069823) 20040800
International Search Report from PCT/EP06/62324 dated Aug. 16, 2006, 4 pages.
(1 485 099) 20100700
Angibaud et al. (7541369) 20090600
(WO 2006/010749) 20060200
Adams et al. (6083903) 20000700
Van Emelen (7884105) 20110200
In the U. S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/506,998 dated Oct. 2, 2008, 5 pages.
(WO-2004/065354) 20040800
(0827742) 19980300
(1 485 370) 20090300
Awada et al., "The pipeline of new anticancer agents for breast cancer treatment in 2003," Oncology Hematology, 2003: 48:45-63.
Bali et al., "A Combination of Histone Deacetylase Inhibitor LAQ 824 and the FLT-3 Kinase Inhibitor PKC412 is Highly Active Against Human AML Cells with Constitutively Active Mutant FLT-3 Tyrosine Kinase," Blood, 2003; 102(11):96a-97b.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/160,140 dated Aug. 9, 2010, 6 pages.
Banker et al., "Prodrugs," Modern pharmaceuticals, Marcel Dekker, Inc., 3rd Ed. 1996; p. 596.
Nawrocki et al., "Aggresome Disruption: A Novel Strategy to Enhance Bortezomib-Induced Apoptosis in Pancreatic Cancer Cells," Cancer Research, 2006; 66(7):3773-3781.
(1 592 665) 20070700
Internal Medicine, 4th Edition, Editor-in-Chief Jay Stein, Chapters 71-72, pp. 699-715, (1994).
In the U.S. Patent and Trademark Office U.S. Appl. No. 11/917,999 Final Office Action dated Feb. 24, 2011, 15 pages.
(WO-00/35855) 20000600
In the U. S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,271 dated Jul. 25, 2007, 12 pages.
(1 682 538) 20090500
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/160,120 dated Sep. 30, 2009, 13 pages.
(1 613 622) 20060100
Dorwald, Side Reactions in organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface.
(1 592 667) 20051100
In the U. S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/372,801 dated Dec. 10, 2009, 7 pages.
(WO-03/076422) 20030900
In the U. S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/539,682 dated Aug. 17, 2010, 8 pages.
Angibaud et al. (7834025) 20101100
(1 002 795) 20000500
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/160,133 dated Sep. 29, 2009, 12 pages.
Van Emelen et al. (7446109) 20081100
In the U. S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,084 dated Jun. 1, 2007, 7 pages.
Ciszewski et al. (6897307) 20050500
(WO 03/076401) 20030900
(1 501 508) 20070200
Banno et al. (4455422) 19840600
Roux et al. (2009/0023726) 20090100
Mitsiades et al., Transcriptional Signature of Histone Deacetylase Inhibition in Multiple Myeloma: Biological and Clinical Implications, PNAS, 2004; 101(2):540-545.
Van Emelen et al. (7205304) 20070400
Freshney et al., "Culture of Animal Cells, A Manual of Basic Technique," Alan R Liss, Inc. 1983 New York, p. 1-6.
Collingwood et al. (6589950) 20030700
Angibaud et al. (2009/0221580) 20090900
(WO-2004/063169) 20040700
(1 472 216) 20041100
(1 485 364) 20090300
(1 485 348) 20080600
(WO 03/076421) 20030900
(1 663 953) 20060600
Carter et al., Chemotherapy of Cancer, Wiley (2nd edition,1981): 362-365.
Lentzsch et al., "Combination of Proteasome Inhibitor PS 341 with Histone Acetylase Inhibitor (HDAC) PXD 101 Shows Superior Anti-Myeloma Activity and Inhibits Osteoclastogenesis," Blood Poster Session, 2005; 106(Abstract 2488):p. 1.
(1 585 735) 20051000
(WO 2006/122926) 20061100
In the U.S. Patent and Trademark Office U.S. Appl. No. 11/572,563 Final Office Action dated Mar. 3, 2011, 5 pages.
(1 312 609) 20051200
Marks et al., "Histone Deacetylases and Cancer: Causes and Therapies," Nature Reviews, 2001, pp. 194-20
References_xml – year: 20000700
  ident: WO-00/43394
– year: 20050400
  ident: 2005/0080258
  contributor:
    fullname: Davis et al.
– year: 19940300
  ident: 042 28 792
– year: 20100900
  ident: 2010/0240639
  contributor:
    fullname: Van Emelen et al.
– year: 20090100
  ident: 2009/0023726
  contributor:
    fullname: Roux et al.
– year: 20070200
  ident: 1 501 508
– year: 20100100
  ident: 2010/0010004
  contributor:
    fullname: Van Emelen et al.
– year: 20110200
  ident: 7884105
  contributor:
    fullname: Van Emelen
– year: 20090600
  ident: 7541369
  contributor:
    fullname: Angibaud et al.
– year: 20110500
  ident: 7947830
  contributor:
    fullname: Van Brandt et al.
– year: 20040200
  ident: WO-2004/013130
– year: 20061200
  ident: WO 2006/136553
– year: 20040100
  ident: 2 491 131
– year: 20100100
  ident: 2010/0009988
  contributor:
    fullname: Van Emelen
– year: 20050800
  ident: 2005/0171347
  contributor:
    fullname: Van Emelen et al.
– year: 20070700
  ident: 1 592 665
– year: 19981200
  ident: WO 98/55449
– year: 20031000
  ident: WO-03/082288
– year: 20050300
  ident: WO-2005/028447
– year: 20060600
  ident: 1 663 953
– year: 20080500
  ident: 1 485 354
– year: 20050500
  ident: WO-2005/040161
– year: 19860700
  ident: 0188094
– year: 20010500
  ident: WO 01/38322
– year: 20060200
  ident: WO-2006/010750
– year: 19740200
  ident: 1 345 872
– year: 20100500
  ident: 7709487
  contributor:
    fullname: Van Emelen et al.
– year: 20070600
  ident: 2007/0135424
  contributor:
    fullname: Van Brandt et al.
– year: 20090300
  ident: 7501417
  contributor:
    fullname: Van Emelen et al.
– year: 20120100
  ident: 8101616
  contributor:
    fullname: Angibaud et al.
– year: 20111200
  ident: 8071615
  contributor:
    fullname: Van Emelen et al.
– year: 19940800
  ident: 5338738
  contributor:
    fullname: Matson et al.
– year: 20040800
  ident: WO-2004/071400
– year: 20050400
  ident: WO-2005/030704
– year: 20040900
  ident: WO-2004/082638
– year: 20020300
  ident: 2002/0032195
  contributor:
    fullname: Breitfelder et al.
– year: 20051000
  ident: WO-2005/092899
– year: 20090300
  ident: 1 485 370
– year: 20090500
  ident: 1 682 538
– year: 20101100
  ident: 7834025
  contributor:
    fullname: Angibaud et al.
– year: 20051200
  ident: 1 608 628
– year: 20100200
  ident: 2010/0048588
  contributor:
    fullname: Van Emelen et al.
– year: 20100900
  ident: 2010/0234353
  contributor:
    fullname: Van Emelen et al.
– year: 20000600
  ident: WO-00/35855
– year: 20091100
  ident: 7615553
  contributor:
    fullname: Van Emelen et al.
– year: 20090300
  ident: 1 485 364
– year: 20101000
  ident: 7816363
  contributor:
    fullname: Angibaud et al.
– year: 20020500
  ident: WO-02/42271
– year: 20051100
  ident: 1 592 667
– year: 20080500
  ident: 1 485 365
– year: 19690800
  ident: 3459731
  contributor:
    fullname: Gramera et al.
– year: 20030900
  ident: WO-03/076422
– year: 20010900
  ident: WO 01/70675
– year: 20050400
  ident: 1 525 199
– year: 20090900
  ident: 2009/0227558
  contributor:
    fullname: Angibaud et al.
– year: 19970700
  ident: WO-97/23216
– year: 19980300
  ident: 0827742
– year: 20050900
  ident: 1 572 626
– year: 19991000
  ident: WO-99/50250
– year: 20090600
  ident: 1 611 088
– year: 20090700
  ident: 2009/0170836
  contributor:
    fullname: Angibaud et al.
– year: 19941100
  ident: WO-94/25437
– year: 20051200
  ident: 1 312 609
– year: 20000500
  ident: WO-00/26203
– year: 20110200
  ident: 7888360
  contributor:
    fullname: Angibaud et al.
– year: 20050500
  ident: WO-2005/040101
– year: 20030900
  ident: WO 03/076400
– year: 20030900
  ident: WO 03/076401
– year: 20040700
  ident: WO-2004/063169
– year: 20090500
  ident: 2009/0124646
  contributor:
    fullname: Verdonck et al.
– year: 20051000
  ident: 1 585 735
– year: 20000900
  ident: WO 00/52001
– year: 19670700
  ident: 3331843
  contributor:
    fullname: Tomcufcik et al.
– year: 20040700
  ident: WO-2004/063146
– year: 20051000
  ident: 1 583 736
– year: 20061100
  ident: WO 2006/122926
– year: 19980700
  ident: 5780454
  contributor:
    fullname: Adams et al.
– year: 20001100
  ident: WO-00/71516
– year: 20050900
  ident: WO-2005/086898
– year: 19851200
  ident: 0 076 530
– year: 20070700
  ident: WO 2007/082880
– year: 19980800
  ident: 5789412
  contributor:
    fullname: Halazy et al.
– year: 20070700
  ident: WO 2007/082882
– year: 20090200
  ident: 2009/0042920
  contributor:
    fullname: Van Emelen et al.
– year: 20091000
  ident: 2009/0270419
  contributor:
    fullname: Arts et al.
– year: 20070700
  ident: WO 2007/082873
– year: 20070400
  ident: 7205304
  contributor:
    fullname: Van Emelen et al.
– year: 20030900
  ident: WO 03/076395
– year: 20040100
  ident: WO-2004/009536
– year: 19920900
  ident: 5147876
  contributor:
    fullname: Mizuchi et al.
– year: 20030200
  ident: 6518283
  contributor:
    fullname: Langham et al.
– year: 20070700
  ident: WO 2007/082874
– year: 20070700
  ident: WO 2007/082876
– year: 20090100
  ident: 2009/0018152
  contributor:
    fullname: Angibaud et al.
– year: 20030500
  ident: 0 788 360
– year: 20070700
  ident: WO 2007/082878
– year: 20050100
  ident: 1 495 002
– year: 20041000
  ident: WO-2004/087693
– year: 19990900
  ident: 5952349
  contributor:
    fullname: Asberom et al.
– year: 20100400
  ident: 7704998
  contributor:
    fullname: Van Emelen et al.
– year: 19960500
  ident: WO-96/13266
– year: 20090100
  ident: 2009/0005393
  contributor:
    fullname: Angibaud et al.
– year: 19910600
  ident: 5025012
  contributor:
    fullname: Miura et al.
– year: 20040800
  ident: WO-2004/065354
– year: 20000700
  ident: 6083903
  contributor:
    fullname: Adams et al.
– year: 20101100
  ident: 7834011
  contributor:
    fullname: Roux et al.
– year: 20050800
  ident: WO-2005/075469
– year: 20010200
  ident: WO-01/09134
– year: 20100900
  ident: 2010/0222574
  contributor:
    fullname: Rombouts et al.
– year: 19940800
  ident: 5342846
  contributor:
    fullname: Singh et al.
– year: 20090900
  ident: 7592450
  contributor:
    fullname: Van Emelen
– year: 20050500
  ident: 2005/0096468
  contributor:
    fullname: Van Emelen et al.
– year: 20000500
  ident: 6066730
  contributor:
    fullname: Adams et al.
– year: 20030200
  ident: WO-03/016306
– year: 20041100
  ident: 1 472 216
– year: 20050500
  ident: 6897307
  contributor:
    fullname: Ciszewski et al.
– year: 20010700
  ident: WO-01/49688
– year: 19620700
  ident: 0 901 749
– year: 20090900
  ident: 2009/0221580
  contributor:
    fullname: Angibaud et al.
– year: 20070500
  ident: WO 2007/048767
– year: 20040200
  ident: 102 33 412
– year: 19770900
  ident: 4049811
  contributor:
    fullname: Berger et al.
– year: 20050900
  ident: 2005/0197336
  contributor:
    fullname: Anandan et al.
– year: 20041200
  ident: 1 485 353
– year: 20030900
  ident: WO 03/076421
– year: 19840600
  ident: 4455422
  contributor:
    fullname: Banno et al.
– year: 20030900
  ident: WO 03/076438
– year: 20081000
  ident: 1 627 880
– year: 20040700
  ident: WO-2004/056748
– year: 19760600
  ident: 3966743
  contributor:
    fullname: Berger et al.
– year: 20050500
  ident: 2005/0107384
  contributor:
    fullname: Angibaud et al.
– year: 20100800
  ident: 7767679
  contributor:
    fullname: Van Emelen et al.
– year: 20020300
  ident: WO-02/18335
– year: 20030900
  ident: WO 03/076430
– year: 20090700
  ident: 2009/0170881
  contributor:
    fullname: Angibaud et al.
– year: 20080600
  ident: 1 485 348
– year: 19980200
  ident: WO-98/05335
– year: 20080600
  ident: 2008/0132459
  contributor:
    fullname: Moradei et al.
– year: 20060100
  ident: 1 613 622
– year: 20031100
  ident: WO-03/092686
– year: 20050200
  ident: 2 518 950
– year: 20030800
  ident: WO-03/066579
– year: 20070800
  ident: 1 685 094
– year: 20100700
  ident: 1 485 099
– year: 20030200
  ident: WO 03/011851
– year: 20000500
  ident: WO-00/27825
– year: 20080300
  ident: WO 2008/031820
– year: 20050400
  ident: WO-2005/030705
– year: 20031000
  ident: WO-03/087057
– year: 20080600
  ident: 1 485 378
– year: 20050400
  ident: 1 523 470
– year: 20040800
  ident: WO-2004/069803
– year: 20030500
  ident: WO-03/035855
– year: 20030700
  ident: 6589950
  contributor:
    fullname: Collingwood et al.
– year: 20080600
  ident: 1 492 534
– year: 20040800
  ident: WO-2004/072047
– year: 20070200
  ident: WO-2007/016532
– year: 19971000
  ident: 2 104 509
– year: 20090100
  ident: 2009/0018153
  contributor:
    fullname: Angibaud et al.
– year: 20090200
  ident: 2009/0036463
  contributor:
    fullname: Angibaud et al.
– year: 20081100
  ident: 7446109
  contributor:
    fullname: Van Emelen et al.
– year: 19970500
  ident: WO-97/18839
– year: 20100600
  ident: 1 673 349
– year: 20041000
  ident: WO-2004/092115
– year: 20041200
  ident: 2004/0248897
  contributor:
    fullname: Priepke et al.
– year: 20051000
  ident: 2005/0222414
  contributor:
    fullname: Van Emelen et al.
– year: 20030900
  ident: WO 03/075929
– year: 20030100
  ident: WO-03/000653
– year: 20000500
  ident: 1 002 795
– year: 20100600
  ident: 2010/0160321
  contributor:
    fullname: Holte et al.
– year: 20040800
  ident: WO-2004/069823
– year: 20020100
  ident: WO-02/00651
– year: 20070700
  ident: 1 581 484
– year: 20010900
  ident: 6294538
  contributor:
    fullname: Mylari
– year: 20060200
  ident: WO 2006/010749
– year: 20100400
  ident: 1 590 340
– year: 20081000
  ident: 2008/0255140
  contributor:
    fullname: Van Emelen
– year: 20090600
  ident: 2009/0143401
  contributor:
    fullname: Marconnet-Decrane et al.
– year: 19820900
  ident: 4348401
  contributor:
    fullname: Friebe et al.
Score 2.8678887
Snippet 1234 This invention comprises the novel compounds of formula (I) wherein n, t, R, R, R, R, L, Q, X, Y, Z and have defined meanings, having histone deacetylase...
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Title Inhibitors of histone deacetylase
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