Label-free sensor
The invention provides a label-free sensor that includes a substrate, a first electrode formed on the substrate, a second electrode formed on the substrate and spaced away from the first electrode, and a semiconductor layer formed on the substrate and being in contact with the first electrode and th...
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Main Authors | , , , , , , , |
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Format | Patent |
Language | English |
Published |
10.07.2012
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Online Access | Get full text |
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Abstract | The invention provides a label-free sensor that includes a substrate, a first electrode formed on the substrate, a second electrode formed on the substrate and spaced away from the first electrode, and a semiconductor layer formed on the substrate and being in contact with the first electrode and the second electrode. The semiconductor layer has a plurality of probe groups bonded to the semiconductor layer by functionalization, for sensing a coupling-specific substance having bonding specificity with the probe groups. The semiconductor layer is bonded with the probe groups, and the detection of detected object is performed in an instant, quick, rapid, and sensitive manner by measuring variation in electric current, avoiding the use of fluorescent reading equipment for reading fluorescent signals. |
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AbstractList | The invention provides a label-free sensor that includes a substrate, a first electrode formed on the substrate, a second electrode formed on the substrate and spaced away from the first electrode, and a semiconductor layer formed on the substrate and being in contact with the first electrode and the second electrode. The semiconductor layer has a plurality of probe groups bonded to the semiconductor layer by functionalization, for sensing a coupling-specific substance having bonding specificity with the probe groups. The semiconductor layer is bonded with the probe groups, and the detection of detected object is performed in an instant, quick, rapid, and sensitive manner by measuring variation in electric current, avoiding the use of fluorescent reading equipment for reading fluorescent signals. |
Author | Hong, Sheng-Fu Liu, Wen-Hsing Dai, Ming-Zhi Liu, Chien-Cheng Chao, Yu-Chiang Li, Jan-Hao Meng, Hsin-Fei Chang, Cheng-Chung |
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References | Lee et al. (7509860) 20090300 Jabs et al. (2006/0121501) 20060600 Briman et al. (2007/0259359) 20071100 Gamo et al. (2010/0084634) 20100400 Kuzmych et al., Nanotechnology, 18:1-7 (2007). Kam et al., J. Am. Chem. Soc., 126:6850-6851 (2004). Hayashi et al. (6365825) 20020400 Green (2010/0294659) 20101100 Ono et al. (2007/0007538) 20070100 Star et al., PNAS, 103(4):921-926 (2006). Agarwala et al. (6734090) 20040500 Cui et al., Science, 293:1289-1292 (2001). |
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Snippet | The invention provides a label-free sensor that includes a substrate, a first electrode formed on the substrate, a second electrode formed on the substrate and... |
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