Antifungal agents

Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors...

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Main Authors Greenlee, Mark L, Wilkening, Robert, Apgar, James, Sperbeck, Donald, Wildonger, Kenneth J, Meng, Dongfang, Parker, Jr, Dann L, Pacofsky, Gregory J, Heasley, Brian H, Mamai, Ahmed, Nelson, Kingsley
Format Patent
LanguageEnglish
Published 29.05.2012
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Summary:Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (1,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.