Medical copolymers
99 9Medical copolymers are provided which comprise (a) a polymer backbone comprising (i) a plurality of -C═C- groups within the polymer backbone, (ii) a plurality of -R- groups within the polymer backbone, wherein Rcomprises a radical-substituted C2-C10 cyclic or heterocyclic group, or (iii) both a...
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| Format | Patent |
| Language | English |
| Published |
29.05.2012
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| Online Access | Get full text |
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| Abstract | 99 9Medical copolymers are provided which comprise (a) a polymer backbone comprising (i) a plurality of -C═C- groups within the polymer backbone, (ii) a plurality of -R- groups within the polymer backbone, wherein Rcomprises a radical-substituted C2-C10 cyclic or heterocyclic group, or (iii) both a plurality of -C═C- groups and a plurality of -R- groups within the polymer backbone, (b) a plurality of hydrocarbon-based pendant groups along the polymer backbone that comprise a saturated or unsaturated carbon chain of at least four carbons in length, and (c) a plurality of zwitterionic pendant groups along the polymer backbone that comprise a positively charged quaternary ammonium group and a negatively charged phosphate group. Methods of forming such copolymers, medical products that contain such copolymers, and methods of making such medical products are also disclosed. |
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| AbstractList | 99 9Medical copolymers are provided which comprise (a) a polymer backbone comprising (i) a plurality of -C═C- groups within the polymer backbone, (ii) a plurality of -R- groups within the polymer backbone, wherein Rcomprises a radical-substituted C2-C10 cyclic or heterocyclic group, or (iii) both a plurality of -C═C- groups and a plurality of -R- groups within the polymer backbone, (b) a plurality of hydrocarbon-based pendant groups along the polymer backbone that comprise a saturated or unsaturated carbon chain of at least four carbons in length, and (c) a plurality of zwitterionic pendant groups along the polymer backbone that comprise a positively charged quaternary ammonium group and a negatively charged phosphate group. Methods of forming such copolymers, medical products that contain such copolymers, and methods of making such medical products are also disclosed. |
| Author | Ippoliti, J. Thomas Schewe, Scott Warner, Robert W Zoromski, Michele |
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| References | V. Amir-Ebrahimi et al., "Copolymerization of cycloalkenes as a probe of the propagation steps in olefin metathesis", Journal of Molecular Catalysis A: Chemical 115 (1997) 85-94. (2004250613) 20040900 R. Collingwood et al., "Stent-Based Delivery of ABT-578 via a Phosphorylcholine Surface Coating Reduces Neointimal Formation in the Porcine Coronary Model", Catheter Cardiovasc. Interv., 65 (2005) 227-232. T. M. Sisson et al., "Novel polymer architectures via the selective polymerization of lyotropic liquid crystals of heterobifunctional amphiphiles", J. Am. Chem. Soc. 1998, 120, 2322-2329. R. Virmani et al.,"Localized Hypersensitivity and Late Coronary Thrombosis Secondary to a Sirolimus-Eluting Stent", Circulation Feb. 17, 2004, 109(6) 701-5. Richard et al. (2007/0269480) 20071100 J. A. Hayward et al., "Biomembrane Surfaces as Models for Polymer Design: The Potential for Haemocompatibility", Biomaterials 5 (1984) 135. Hauenstein (2007/0141104) 20070600 Tegoulia et. al., "Surface Properties, Fibrinogen Adsorption, and Cellular Interactions of a Novel Phosphorylcholine-Containing Self-Assembled Monolayer on Gold", Langmuir 2001, 17, 4396-4404. D.M. Whelan et al., "Biocompatibility of phosphorylcholine coated stents in normal porcine coronary arteries", Heart ;83 (2000) 338-345. A. L. Lewis et al., "Synthesis and Characterization of phosphorylcholine-based polymers useful for coating blood filtration devices", Biomaterials 21 (2000) 1847-1859. S.F. Zhang et al., "Physical and Biological Properties of Compound Membranes Incorporating a Copolymer with a Phosphoylcholine Head Group", Biomaterials 19 (1998) 691-700. Bowden et al. (2006/0147490) 20060700 (01/01957) 20010100 J. Das et al., "Synthesis and Pharmacological Evaluation of 5,6exo -Epoxy-7-oxabicyclo[ 2.2.1] heptane Derivatives", J. Med. Chem. 31 (1988) 930-935. (98/55487) 19981200 N. Malik et al., "Phosporylcholine-Coated Stents in Porcine Coronary Arteries: In Vivo Assessment of Biocompatibility", J. Invasive Cardiol. 13 (2001) 193-201. A.L. Lewis et al., "Blending in with the Body", J. Chem. Ed., 79(3), Mar. 2002, 321-326. Ring Opening Metathesis Polymerization, 4 pp., downloaded from http://www.ilpi.com/organomet/romp.html on Mar. 10, 2008. (02/055121) 20020700 S. Ranade et al., "Physical characterization of controlled release of paclitaxel from the TAXUS™ Express2™ drug-eluting stent", Journal of Biomedical Materials Research Part A, 71A (2004) 625-634. S. Chen et al., "Strong Resistance of Oligo(phosphorylcholine) Self-Assembled Monolayers to Protein Adsorption", Langmuir 2006, 22, 2418-2421. Emrick et al. (2008/0142454) 20080600 |
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