Plant production of immunoglobulins with reduced fucosylation

This invention provides for the plant production of immunoglobulins, wherein at least a portion of the glycans attached to the immunoglobulins lack fucose. The invention also provides the constructs; plasmids; vectors; transformed plant cells, transformed plant calli; transformed plant tissues (e.g....

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Main Authors Briggs, Kristen, Glancy, Todd, Hein, Mich B, Hiatt, Andrew C, Karnoup, Anton S, Anderson, W. H. Kerr, Pareddy, Dayakar, Petolino, Joseph, Rubin-Wilson, Beth, Taylor, Doug, Roberts, Jean L
Format Patent
LanguageEnglish
Published 31.01.2012
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Summary:This invention provides for the plant production of immunoglobulins, wherein at least a portion of the glycans attached to the immunoglobulins lack fucose. The invention also provides the constructs; plasmids; vectors; transformed plant cells, transformed plant calli; transformed plant tissues (e.g., leaves, seeds, tubers, etc.); transformed whole plants used to produce such immunoglobulins; methods of producing the immunoglobulins; the immunoglobulins produced by the disclosed methods; and the use of such immunoglobulins.