Microorganism of

Neurospora crassaNeurospora crassaNeurospora crassaNeurospora crassaProvided is a microorganism belonging to the family Enterobacteriaceae including: a polynucleotide encoding N-trimethyllysine hydroxylase activity derived from ; a polynucleotide encoding 3-hydroxy-6-N-trimethyllysine aldolase activ...

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Main Authors Lee, Bheong-Uk, Kang, Whan-Koo, Park, Young-Hoon, Koh, Eun-Sung, Chung, Sung-Oh, Ju, Jae-Yeong
Format Patent
LanguageEnglish
Published 08.03.2011
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Abstract Neurospora crassaNeurospora crassaNeurospora crassaNeurospora crassaProvided is a microorganism belonging to the family Enterobacteriaceae including: a polynucleotide encoding N-trimethyllysine hydroxylase activity derived from ; a polynucleotide encoding 3-hydroxy-6-N-trimethyllysine aldolase activity derived from ; a polynucleotide encoding γ-trimethylaminoaldehyde dehydrogenase activity derived from ; and a polynucleotide encoding γ-butyrobetaine hydroxylase activity derived from . Provided is also a process for producing L-carnitine using the microorganism.
AbstractList Neurospora crassaNeurospora crassaNeurospora crassaNeurospora crassaProvided is a microorganism belonging to the family Enterobacteriaceae including: a polynucleotide encoding N-trimethyllysine hydroxylase activity derived from ; a polynucleotide encoding 3-hydroxy-6-N-trimethyllysine aldolase activity derived from ; a polynucleotide encoding γ-trimethylaminoaldehyde dehydrogenase activity derived from ; and a polynucleotide encoding γ-butyrobetaine hydroxylase activity derived from . Provided is also a process for producing L-carnitine using the microorganism.
Author Park, Young-Hoon
Lee, Bheong-Uk
Kang, Whan-Koo
Koh, Eun-Sung
Ju, Jae-Yeong
Chung, Sung-Oh
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References International Search Report (Form PCT/ISA/210); PCT/KR2005/002323; Mailed Apr. 19, 2006 (5 sheets).
Vandecasteele et al. (4221869) 19800900
Chung et al., Database WPI Week 200673, Jan. 2006, XP002504316 (Abstract Only).
Galagan et al."The Genome Sequence of Filamentous . . . ", Nature, Apr. 2003, vol. 422, pp. 859-868.
Kaufman, et al., Biosynthesis of carnitine in Neurospora crassa, J. Biol Chem, Nov. 10, 1977, pp. 7437-7439, vol. 252(21).
Kulla et al. (4708936) 19871100
(WO 95/10613) 19950400
Cavazza (4371618) 19830200
(3123975) 19820300
(1020060005189) 20060100
(2007007987) 20070100
Seim et al. (5028538) 19910700
Rebouche, et al., Carnitine biosybthesis in Neurospora carassa: enzymatic conversion of lysine to epsilon-N-trimethyllysine, J. Bacteriol, Jun. 1976, pp. 1207-1214, vol. 126(3).
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