Dermatitis treating agent
The present invention is to provide a topical dermatitis treating agent which comprises a pyridine compound represented by the following formula [I]:
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Format | Patent |
Language | English |
Published |
11.01.2011
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Online Access | Get full text |
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Abstract | The present invention is to provide a topical dermatitis treating agent which comprises a pyridine compound represented by the following formula [I]: |
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AbstractList | The present invention is to provide a topical dermatitis treating agent which comprises a pyridine compound represented by the following formula [I]: |
Author | Kikuchi, Matsuo Naotsuka, Atsuko |
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References | E. Frigas et al., "The Eosinophil and the Pathophysiology of Asthma," The Journal of Allergy and Clinical Immunology, vol. 77, No. 4, pp. 527-537 (Apr. 1986). (0 848 000) 20020600 (9-59255) 19970300 (2006-151964) 20060600 A. Ehinger et al., "Effects of the Phosphodiesterase 4 Inhibitor RPR 73401 in a Model of Immunological Inflammation," European Journal of Pharmacology, vol. 392, pp. 93-99 (2000). W. Baumer et al., "Effects of the Phosphodiesterase 4 Inhibitors SB 207499 and AWD 12-281 on the Inflammatory Reaction in a Model of Allergic Dermatitis," European Journal of Pharmacology, vol. 446, pp. 195-200 (2002). Ukita et al. (6005106) 19991200 De Brito et al., "Type 4 Phosphodiesterase Inhibitors and Their Potential in the Treatment of Inflammatory Disease," Emerging Drugs (1997) 2:249-268. Ukita et al. (5965730) 19991000 Supplementary European Search Report and Search Opinion for application EP06811270 based on PCT/JP2006/319932, (2006). Kaminuma et al., "A Novel Phosphodiesterase Inhibitor, T-440: Possible Management of Eosinophilic Inflammation by Down-Regulation of Interleukin-5 Production," Int Arch Allergy Immunol. (1996) 111(suppl 1):16-18. Ukita et al., "Novel, Potent, and Selective Phosphodiesterase-4 Inhibitors as Antiasthmatic Agents: Synthesis and Biological Activities of a Series of 1-Pyridylnaphthalene Derivatives," J. Med. Chem. (1999) 42:1088-99. D. Griswold et al., "SB 207499 (Ariflo), a Second Generation Phosphodiesterase 4 Inhibitor, Reduces Tumor Necrosis Factor α and Interleukin-4 Production in vivo," The Journal of Pharmacology and Experimental Therapeutics, vol. 287, No. 2, pp. 705-711 (1998). (10-226685) 19980800 (2000-63275) 20000200 Dyke & Montana, "The therapeutic potential of PDE4 inhibitors," Exp. Opin. Invest. Drugs (1999) 8(9):1301-25. I. Iwamoto et al., "Role of CD4+ T Lymphocytes and Interleukin-5 in Antigen-Induced Eosinophil Recruitment into the Site of Cutaneous Late-Phase Reaction in Mice," Journal of Leukocyte Biology, vol. 52, pp. 572-578 (Nov. 1992). Ukita et al., "Synthesis and Biological Activities of 1-Pyridylisoquinoline and 1-Pyridyldihydroisoquinoline Derivatives as PDE4 Inhibitors," Bioorganic & Medicinal Chemistry Letters (2003) 13:2347-50. (WO 2004/067006) 20040800 (0 748 805) 19961200 |
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Snippet | The present invention is to provide a topical dermatitis treating agent which comprises a pyridine compound represented by the following formula [I]: |
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Title | Dermatitis treating agent |
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