Test strip for creatinine determination

1 34 6 32357 23 146 4 The present invention provides a novel test piece for creatinine measurement. The test piece includes a compound expressed by the following formula (1), a metal that forms a colored complex with the compound, and a buffer agent in a porous material. The amount of creatinine is...

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Main Author Kosaka, Hideko
Format Patent
LanguageEnglish
Published 26.10.2010
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Abstract 1 34 6 32357 23 146 4 The present invention provides a novel test piece for creatinine measurement. The test piece includes a compound expressed by the following formula (1), a metal that forms a colored complex with the compound, and a buffer agent in a porous material. The amount of creatinine is determined by optically measuring a colored complex of the compound and the metal and evaluating the degree of inhibition of the colored complex formation by creatinine. In the formula (1), Rrepresents H, SOX, or COOX. Rand Rrepresent OH, SOX, or COOX and may be either the same or different. R, R, R, and Rrepresent H, OH, Cl, Br, I, NO, NO, or CHand may be either the same or different. Xs in the R, R, and Rrepresent H, Na, K, or NHand may be either the same or different.
AbstractList 1 34 6 32357 23 146 4 The present invention provides a novel test piece for creatinine measurement. The test piece includes a compound expressed by the following formula (1), a metal that forms a colored complex with the compound, and a buffer agent in a porous material. The amount of creatinine is determined by optically measuring a colored complex of the compound and the metal and evaluating the degree of inhibition of the colored complex formation by creatinine. In the formula (1), Rrepresents H, SOX, or COOX. Rand Rrepresent OH, SOX, or COOX and may be either the same or different. R, R, R, and Rrepresent H, OH, Cl, Br, I, NO, NO, or CHand may be either the same or different. Xs in the R, R, and Rrepresent H, Na, K, or NHand may be either the same or different.
Author Kosaka, Hideko
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References Itsuo Mori, "Spectrophotometric Determination of Creatinine using o-Hydroxy-hydroquinonephthalein-Palladium (II) Complex", 1983, Chem. Pharm. Bull. 31 (4), p. 1389-1391.
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Pugia (5374561) 19941200
(0 952 451) 19991000
Yip (5464777) 19951100
Pugia (5399498) 19950300
Mori, et al.. "Spectrophotometric Determination of Creatinine using o-Hydroxy-hydroquinonephthalein-Palladium (iII) Complex", Chem. Pharm. Bull. 31 (4) 1389-1391, 1983, XP009104072.
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Roy W. Bonsnes et al., "On the Colorimetric Determination of Creatinine by the Jaffe Reaction", Journal of Biological Chemistry, 1945, 158, pp. 581-591.
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Stanley R. Benedict et al., "Some Applications of a New Color Reaction for Creatinine", Journal of Biological Chemistry, 1936, 113, p. 515-532.
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Yang, Dingguo, "Study on chromogenic reaction of palladium (II) with Chrome Azurol B-cetyldimethylammonium acetate-Triton X-100 and its application", Chemical Abstracts Service, 1990, XP002490393.
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Enzo Tanganelli et al., "Enzymic Assay of Creatinine in Serum and Urine with Creatinine Lminohydrolase and Glutamate Dehydrogenase", Clinical Chemistry, 1982, 28, p. 1461-1464.
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