Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives

The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hy...

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Main Authors Davis, S. Christopher, Grate, John H, Gray, David R, Gruber, John M, Huisman, Gjalt W, Ma, Steven K, Newman, Lisa M, Sheldon, Roger, Wang, Li A
Format Patent
LanguageEnglish
Published 05.10.2010
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Summary:The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.