Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level

The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount...

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Main Authors Chu, Zhi-Liang, Leonard, James N, Al-Shamma, Hussien A, Jones, Robert M
Format Patent
LanguageEnglish
Published 28.09.2010
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Abstract The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues.
AbstractList The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues.
Author Chu, Zhi-Liang
Leonard, James N
Jones, Robert M
Al-Shamma, Hussien A
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References Holst et al., "Inhibition of the Activity of Dipeptidyl-Peptidase IV as a Treatment for Type 2 Diabetes," Diabetes, 47:1663-1670 (1998).
(10251927) 20040500
Ahren et al., "Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes,"J Clin Endocrinol Metab (2004), 89:2078-2084.
(WO 2007/003961) 20070100
(WO 00/12704) 20000300
(WO 2004/046106) 20040600
Maeda et al, Nat Med, 8:731-737, (2002).
Jones et al., "GPR 119 agonists for the treatment of type 2 diabetes," Expert Opinion Therapeutic Patents, 19(10):1339-1359 (2009).
(WO 2005/009956) 20050200
(WO 2006/012395) 20060200
(2005507261) 20050300
McIntosh et al., "Dipeptidyl peptidase IV inhibitors: How do they work as new antidiabetic agents?" Regulatory Peptides, 128:159-165, (2005).
Oku et al, FEBS Letters 581:5029-5033, (2007).
Lippincott Williams & Wilkins; and Handbook of Pharmaceutical Excipients (Rowe et al., eds), 4th Edition, Pharmaceutical Press; 2003.
(WO 00/31258) 20000600
(WO 2005/049022) 20050600
Jones et al. (2005/0070562) 20050300
(WO 2004/092128) 20041000
Souli et al Peptides, 18:551-557, (1997).
(1338592) 20030800
(WO 03/002530) 20030100
Matsuda et al, J Biol Chem 277:37487-37491, (2002).
Altschul et al., "Basic Local Alignment Search Tool," J. Mol. Biol 215:403-410, (1990).
Ausubel et al., Short Protocols in Molecular Biology, 3rd Edition, Wiley & Sons (1995).
Yoshikawa et al. (2004/0116328) 20040600
(1043328) 20001000
(1296974) 20030400
(WO 99/67278) 19991200
Isales et al. (6410508) 20020600
Sakashita et al. (2004/0259883) 20041200
(2824825) 20021100
Nightingale et al, Gut, 39:267-272, (1996).
(2123128) 19930500
Himmelsbach et al. (7645763) 20100100
(2004269468) 20040900
(10256264) 20040600
Overton et al., "GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity," British Journal of Pharmacology, 153:S76-S81 (2008).
Villhauer et al., "1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties," J Med Chem (2003) 46:2774-2789.
Overton et al., "Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents", Cell Metabolism, 3:167-175, (2006).
(WO 2006/070208) 20060600
Hulin et al. (6710040) 20040300
(2003327532) 20031100
Uttenthal, "The Anorectic Gut Hormones: GLP-1 and Co-Secreted Peptides," CLI, pp. 1-4 (2007).
(WO 02/083128) 20021000
Grandt et al, Regul Pept, 51:151-159, (1994).
Jones et al. (2007/0078150) 20070400
Chu et al., "AR231453 mediates improved glycemic control exclusively via GDIR/GPR119", Abstract # 117 & Poster, Diabetes: Molecular Genetics, Signaling Pathways and Integrated Physiology, Keystone Symposia, Jan. 14, 2007-Jan. 19, 2007, Keystone, Colorado.
(1538217) 20050600
(WO 2006/023750) 20060300
(2004521149) 20040700
Sulsky et al. (2002/0183367) 20021200
(1254113) 20021100
Chen et al., "CD26," J. Biol Regul Homest Agents (2004)18:47-54.
Bollag et al., "Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors", Endocrinology, 141:1228-1235, (2000).
(WO 2005/058901) 20050600
(WO2006/015699) 20060200
Hara et al, Diabetes Care, 29:1357-1362, (2006).
(WO 03/002595) 20030100
Pei et al., "Discovery and Structure-Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors," J. Med. Chem., 50:1983-1987 (2007).
DeNanteuil et al. (2003/0087950) 20030500
(2004002368) 20040100
Chu et al. (2007/0072804) 20070300
(WO 98/50066) 19981100
Peters, et al., "Aminomethylpyrimidines as novel DPP-IV inhibitors a 10(5)-fold activity increase by optimization of aromatic substituents.," Bioorg Med Chem Lett (2004), 14:1491-1493.
(WO 01/96295) 20011200
(2289124) 19981100
(WO 91/16339) 19911000
Hay et al, J Clin Gastroenterol, 14:309-317, (1992).
(WO 2005/095339) 20051000
(2000327689) 20001100
Niestroj et al. (6844316) 20050100
(WO 03/074500) 20030900
(2004244412) 20040900
(2004530729) 20041000
(1399470) 20040300
(WO 01/34594) 20010500
(2002356472) 20021200
Milligan et al, "Chimaeric G alpha proteins: their potential use in drug discovery," Trends in Pharmaceutical Sciences (1999), 20:118-24.
Boehringer et al. (2003/0195188) 20031000
Fyfe et al., "New Nonpeptide-binding, GPCRs as Targets of Diabetes and the Metabolic Syndrome," Ann. Rep. Med. Chem., 42:129-145 (2007).
Ashton et al. (7026316) 20060400
Jones et al. (7470699) 20081200
(WO 2004/104215) 20041200
(WO 2008/005576) 20080100
(WO 2005/085246) 20050900
(WO 2007/120689) 20071000
(WO 2004/048379) 20040600
(WO 2005/030127) 20050400
(1489088) 20041200
Chavez-Eng CM et al., J ChromatogrB Analyt Technol Biomed Life Sci, 767:117-29, (2002).
(WO 9938501) 19990800
(WO 2005/000846) 20050100
Yamada et al., "History of GLP-1 Studies," Endocrinology & Diabetology, 23:237-243 (2006) [English translation of Japanese reference].
(WO 99/62914) 19991200
(WO 02/062764) 20020800
(WO2008/025798) 20080300
(WO 93/10127) 19930500
U.S. Appl. No. 60/486,728, filed Jul. 11, 2003, Jones et al.
(WO 03/068748) 20030800
(WO 2006/058064) 20060600
(0980249) 20000200
(2339537) 20000300
Silver et al., Proc. Natl. Acad. Sci. USA, 81:5951-59SS, (1984).
(WO 2005/116014) 20051200
(WO 02/076450) 20021000
Demuth et al. (2003/0162820) 20030800
Ahren, et al., "Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes," Diabetes Care (2002), 25:869-875.
Demuth et al. (2003/0125304) 20030700
Jones et al. (2007/0072844) 20070300
(WO 03/095425) 20031100
Fredriksson R. et al., "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives," FEBS lett. (2003) 20;554(3)381-8.
Wise et al., "The identification of ligands at orphan G-protein coupled receptors", Annu. Rev. Pharmacol. Toxicol., 44:43-66, (2004).
Crespo et al., "Morphometric and mechanical properties of femora in young adult male turkeys with and without femoral fractures", Poultry Science, 79:602-608, (2000).
(1995501078) 19950200
(WO 2005/044195) 20050500
Keire et al, Am J Physiol Gastrointest Liver Physiol 279:G126-G131, (2000).
(WO 03/101958) 20031200
Sondhi, S. et al., "cDNA array reveals increased expression of glucose-dependent insulinotropic polypeptide following chronic clozapine treatment: role in atypical antipsychotic drug-induced adverse metabolic effects", The Pharmacogenomics Journal, 6:131-140, (2006).
Polidori et al. (2007/0032420) 20070200
Villhauer (6166063) 20001200
Demuth et al. (6946480) 20050900
(WO 2006/039325) 20060400
(WO 2004/014860) 20040200
Abramowicz M.; Zuccotti G.: "Drugs for diabetes", Treatment Guidelines from the Medical Letter 3(36):57-62, (2005).
(1215207) 20020600
Boehringer et al. (6861440) 20050300
Takasaki Kotaro et al, "Effects of combination treatment with dipeptidyl peptidase IV inhibitor and sulfonylurea on glucose levels in rats," J. Pharmacol Sciences (2004);95(2):291-293.
(WO 01/97808) 20011200
Sanofi Aventis AVE0010-R&D Meeting, (Sep. 17, 2007).
(WO 2004/018468) 20040300
Ashton et al. (2006/0074087) 20060400
Tao et al, Circulation, 115:1408-1416, (2007).
Yokota et al, Blood, 96:1723-1732, (2000).
(WO 2006/000576) 20060100
Ekstrand et al, PNAS USA 100:6033-6038, (2003).
Pearson, Nursing Times 100:86-90, (2004).
(1658066) 20060500
(WO 2004/037169) 20040500
Holst, "Treatment of Type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors," Expert Opinion on Emerging Drugs, 9(1):155-166 (2004).
Himmelsbach et al. (7501426) 20090300
Endocrinology and Metabolism 4th Edition, Felig et al., Eds. (2001), McGraw-Hill Book Company.
Pierau et al. (2006/0046978) 20060300
Reimer et al., "Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice," Eur. J Endocrinol., 146(5):717-727 (2002).
(WO 2004/007468) 20040100
Tatemoto et al, Nature, 285:417-418, (1980).
Offermanns et al., "G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C.," J Biol Chem (1995), 270:15175-80.
(WO 03/072556) 20030900
(WO 2006/020017) 20060200
(1635818) 20060300
(0641347) 19950300
(2001510442) 20010700
(WO 03/015775) 20030200
Overton et al., "GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity", British Journal of Pharmacology, pp. 1-6, Nov. 26, 2007.
Raisz, Lawrence G., "Pathogenesis of osteoporosis: concepts, conflicts, and prospects", The Journal of Clinical Investigation, 115(12):3318-3325, (2005).
Schwartz, S.L. et al., Clinical Therapeutics, 30(6):1081-8, (2008).
Ohashi et al, Hypertension, 47:1108-1116, (2006).
(WO 2004/076413) 20040900
(1092727) 20010400
(WO 2006/083491) 20060800
(WO 2005/007658) 20050100
Adrian et al, Gastroenterol 89:1070-1077, (1985).
Yoshikawa et al. (7074798) 20060700
(WO 2006/047248) 20060500
Guerre-Millo, Diabetes & Metabolism, 34:12-18, (2008).
(WO 2007/003964) 20070100
Gishl et all, Nature Genetics 3:266-272, (1993).
Berge et al., "Pharmaceutical salts," Journal of Pharmaceutical Sciences (1977) 66:1-19.
Tilg et al, Nat Rev Immunol, 6:772-783, (2006).
(WO 2005/042533) 20050500
Mather et al., Annals N. Y. Acad. Sci 383:44-68, (1982).
(2004525929) 20040800
(WO 2004/043940) 20040500
(WO 2005/051950) 20050600
Ashton et al. (2006/0069116) 20060300
(WO 03/024942) 20030300
(2004534836) 20041100
Duffy et al. (2006/0052382) 20060300
McFadden et al, Am J Surg, 188:516-519, (2004).
He et al. (5922576) 19990700
(2000511559) 20000900
Chu et al., "Agonists of the orphan GPCR 19AJ promote insulin secretion by stimulating both GLP-1-producing endocrine cells and pancreatic β-cells", Abstract #112, p. 42, Diabetes Mellitus: Molecular Mechanisms, Genetics and New Therapies, Keystone Symposia, Jan. 27, 2005-Feb. 2, 2005, Keystone, Colorado.
(1476429) 20041100
(WO 03/040174) 20030500
(0528858) 19930300
Akiyama et al. (2006/0039974) 20060200
(WO 2004/099134) 20041100
Hamann et al. (6995183) 20060200
(WO 2005/106011) 20051100
(WO2006/015691) 20060200
(WO 02/30891) 20020400
Handbook of Pharmaceutic
References_xml – year: 20060200
  ident: 6995183
  contributor:
    fullname: Hamann et al.
– year: 20070700
  ident: 7238670
  contributor:
    fullname: Natarajan et al.
– year: 20040100
  ident: WO 2004/007468
– year: 20050200
  ident: WO2005/012312
– year: 20041200
  ident: WO 2004/104215
– year: 20040500
  ident: 10251927
– year: 20060400
  ident: 2006/0074087
  contributor:
    fullname: Ashton et al.
– year: 20050500
  ident: WO 2005/042533
– year: 20051100
  ident: WO 2005/108382
– year: 20031000
  ident: 1354882
– year: 20021200
  ident: 2002363157
– year: 20021200
  ident: 2002356471
– year: 20050600
  ident: 1538217
– year: 20030600
  ident: 2466870
– year: 19990400
  ident: WO 99/16864
– year: 20050700
  ident: WO 2005/063750
– year: 20070300
  ident: 2007/0072803
  contributor:
    fullname: Chu et al.
– year: 20050500
  ident: WO 2005/040095
– year: 20060200
  ident: WO 2006/020017
– year: 20031000
  ident: 2003/0195188
  contributor:
    fullname: Boehringer et al.
– year: 20050200
  ident: WO2005/012308
– year: 20030200
  ident: WO 03/015775
– year: 20000600
  ident: WO 00/31258
– year: 20060700
  ident: WO 2006/071762
– year: 20000800
  ident: 6100234
  contributor:
    fullname: Huber
– year: 20041200
  ident: WO 2004/110375
– year: 20070100
  ident: WO 2007/003960
– year: 20020100
  ident: WO 02/02560
– year: 20040400
  ident: 1404675
– year: 20040200
  ident: WO 2004/104216
– year: 20070400
  ident: 2007/0082874
  contributor:
    fullname: Jones et al.
– year: 20040400
  ident: 6727261
  contributor:
    fullname: Gobbi et al.
– year: 20060600
  ident: WO 2006/070208
– year: 20060300
  ident: 2006/0052382
  contributor:
    fullname: Duffy et al.
– year: 20030700
  ident: WO 03/055881
– year: 20040100
  ident: 1377288
– year: 20070700
  ident: 7238671
  contributor:
    fullname: Natarajan et al.
– year: 20060600
  ident: WO2006/0068163
– year: 20040500
  ident: WO 2004/043940
– year: 19990700
  ident: 5922576
  contributor:
    fullname: He et al.
– year: 20040300
  ident: 1399154
– year: 20061200
  ident: 1287133
– year: 20030100
  ident: WO 03/000181
– year: 20050400
  ident: WO 2005/032590
– year: 20060400
  ident: WO 2006/039325
– year: 20031200
  ident: WO 03/104229
– year: 20030900
  ident: 6617340
  contributor:
    fullname: Villhauer et al.
– year: 20021000
  ident: 2822826
– year: 19960900
  ident: 0731789
– year: 20060200
  ident: 1627870
– year: 20060700
  ident: WO 2006/070208
– year: 20010900
  ident: WO 01/68603
– year: 20041000
  ident: WO 2004/087650
– year: 20060700
  ident: 7074794
  contributor:
    fullname: Kitajima et al.
– year: 20040300
  ident: WO 2004/018468
– year: 20040900
  ident: WO 2004/076433
– year: 20040800
  ident: 2004525929
– year: 20031100
  ident: 2003/0216450
  contributor:
    fullname: Evans et al.
– year: 20050300
  ident: WO 2005/023762
– year: 20040300
  ident: 10238243
– year: 20000800
  ident: 6100042
  contributor:
    fullname: Fowlkes et al.
– year: 19930500
  ident: 2123128
– year: 20041100
  ident: 1476435
– year: 20000200
  ident: 0975359
– year: 20040600
  ident: WO 2004/052362
– year: 20001200
  ident: 6166063
  contributor:
    fullname: Villhauer
– year: 20040200
  ident: WO 2004/014860
– year: 20040300
  ident: 1399420
– year: 20060300
  ident: 2006/0046978
  contributor:
    fullname: Pierau et al.
– year: 20030800
  ident: WO 03/068757
– year: 20050800
  ident: WO 2005/072530
– year: 20051200
  ident: WO 2005/116029
– year: 20030400
  ident: 1301187
– year: 20060100
  ident: WO 2006/000576
– year: 20040400
  ident: 1406873
– year: 19951100
  ident: WO 95/29691
– year: 20021100
  ident: 1258476
– year: 20040600
  ident: WO 2004/052850
– year: 20021000
  ident: 1245568
– year: 20021200
  ident: 2002356472
– year: 20030800
  ident: WO 03/068748
– year: 20031000
  ident: 2003531204
– year: 20040400
  ident: 2004/0082570
  contributor:
    fullname: Yoshikawa et al.
– year: 20010300
  ident: 1082314
– year: 20051000
  ident: WO 2005/094323
– year: 20041200
  ident: WO 2004/108730
– year: 20050200
  ident: 2005505531
– year: 20060600
  ident: WO 2006/067531
– year: 20010200
  ident: 6183974
  contributor:
    fullname: Bringhurst et al.
– year: 20000300
  ident: WO 00/10549
– year: 20030100
  ident: WO 03/004498
– year: 20060100
  ident: 200410032263
– year: 20040300
  ident: WO 2004/024943
– year: 19790900
  ident: 4166452
  contributor:
    fullname: Generales, Jr. et al.
– year: 19871100
  ident: 4704362
  contributor:
    fullname: Itakura et al.
– year: 20040500
  ident: WO 2004/037169
– year: 20031000
  ident: 2003531191
– year: 20020400
  ident: 2002/0049164
  contributor:
    fullname: Demuth et al.
– year: 20060800
  ident: WO 2006/083491
– year: 20050900
  ident: WO 2005/082906
– year: 20041200
  ident: 1489088
– year: 20060700
  ident: WO 2006/071752
– year: 20050100
  ident: 2005023038
– year: 20080600
  ident: WO 2008070692
– year: 20030600
  ident: 2003/0119738
  contributor:
    fullname: Niestroj et al.
– year: 20060600
  ident: 1671649
– year: 20050300
  ident: WO 2005/021536
– year: 20050400
  ident: WO 2005/033099
– year: 20060800
  ident: 7084120
  contributor:
    fullname: Demuth et al.
– year: 20050200
  ident: WO 2005/009956
– year: 20040500
  ident: WO 2004/041795
– year: 20040200
  ident: 2004/0034014
  contributor:
    fullname: Kanstrup et al.
– year: 20060700
  ident: 2006/0154866
  contributor:
    fullname: Chu et al.
– year: 20000400
  ident: WO 00/22129
– year: 20050600
  ident: WO 2005/051950
– year: 20060200
  ident: 2006/0040963
  contributor:
    fullname: Mathvink et al.
– year: 19810500
  ident: 4265874
  contributor:
    fullname: Bonson et al.
– year: 20051100
  ident: WO 2005/106011
– year: 20080100
  ident: WO 2008/005569
– year: 20060600
  ident: 2006/0135512
  contributor:
    fullname: Boehringer et al.
– year: 20080100
  ident: WO 2008/008895
– year: 20020900
  ident: 2002265439
– year: 19980500
  ident: WO 98/19998
– year: 20050900
  ident: WO 2005/079795
– year: 20060200
  ident: 2006/0024313
  contributor:
    fullname: Chen et al.
– year: 20011200
  ident: WO 01/97808
– year: 20040600
  ident: WO 2004/046106
– year: 20040800
  ident: 1442049
– year: 20041200
  ident: 2004/0259903
  contributor:
    fullname: Boehringer et al.
– year: 20071200
  ident: 2007/0287670
  contributor:
    fullname: Natarajan et al.
– year: 20041200
  ident: WO 2004/110436
– year: 20050200
  ident: 2005/0038020
  contributor:
    fullname: Hamann et al.
– year: 20050300
  ident: 1513808
– year: 20090300
  ident: 7501426
  contributor:
    fullname: Himmelsbach et al.
– year: 20051200
  ident: WO 2005/121131
– year: 20040100
  ident: WO 2004/007446
– year: 20040200
  ident: 2004035574
– year: 20050800
  ident: WO 2005/075426
– year: 20020400
  ident: WO 02/30890
– year: 20060400
  ident: WO 2006/040625
– year: 20071000
  ident: WO 2007/120702
– year: 20060800
  ident: 7094800
  contributor:
    fullname: Schoenafinger et al.
– year: 20060200
  ident: WO2006/015691
– year: 20041200
  ident: WO 2004/103993
– year: 20030600
  ident: 2003/0105077
  contributor:
    fullname: Kanstrup et al.
– year: 20041000
  ident: 2004530729
– year: 20051000
  ident: WO 2005/095381
– year: 20041200
  ident: 2004/0259883
  contributor:
    fullname: Sakashita et al.
– year: 20040900
  ident: WO 2004/076413
– year: 20051200
  ident: WO 2005/121089
– year: 20050100
  ident: 2005500321
– year: 20041100
  ident: 2004534836
– year: 20020800
  ident: 6432969
  contributor:
    fullname: Villhauer et al.
– year: 20040300
  ident: 10238477
– year: 20030100
  ident: WO 03/002553
– year: 20060300
  ident: WO2006/027204
– year: 20000400
  ident: WO 00/023421
– year: 20001100
  ident: 2000327689
– year: 20050100
  ident: 10327439
– year: 20020800
  ident: 2002517401
– year: 20030100
  ident: WO 03/000180
– year: 20031100
  ident: WO 03/095425
– year: 20031100
  ident: 6645995
  contributor:
    fullname: Kanstrup et al.
– year: 20000300
  ident: 6040145
  contributor:
    fullname: Huber
– year: 20041000
  ident: WO 2004/092128
– year: 20040500
  ident: 2004/0087587
  contributor:
    fullname: Himmelsbach et al.
– year: 20041200
  ident: 1490335
– year: 20040400
  ident: WO 2004/032836
– year: 20041200
  ident: 2004536115
– year: 20030300
  ident: 10143840
– year: 20000300
  ident: WO 00/12704
– year: 20030600
  ident: WO 03/045977
– year: 20070400
  ident: 2007/0078150
  contributor:
    fullname: Jones et al.
– year: 20031200
  ident: WO 03/101448
– year: 20070100
  ident: WO 2007/003961
– year: 20050300
  ident: WO 2005/025554
– year: 20041000
  ident: 1465891
– year: 19971000
  ident: 19616486
– year: 19930400
  ident: WO 93/08259
– year: 20060300
  ident: WO 2006/029769
– year: 20060200
  ident: WO 2006/012441
– year: 20060600
  ident: WO 2006/067532
– year: 19950300
  ident: 0641347
– year: 20030500
  ident: WO 03/037327
– year: 20030900
  ident: WO 03/072556
– year: 20050200
  ident: WO 2005/011581
– year: 20050400
  ident: WO 2005/037828
– year: 20001100
  ident: WO 00/69868
– year: 20040500
  ident: WO 2004/037181
– year: 20070500
  ident: 7217711
  contributor:
    fullname: Eckhardt et al.
– year: 20060600
  ident: 7060722
  contributor:
    fullname: Kitajima et al.
– year: 20040100
  ident: 2004026820
– year: 20030500
  ident: 2003/0100563
  contributor:
    fullname: Edmondson et al.
– year: 20090600
  ident: 7550455
  contributor:
    fullname: Himmelsbach et al.
– year: 20040300
  ident: WO 2004/018469
– year: 20070700
  ident: 2007/0155763
  contributor:
    fullname: Jones et al.
– year: 20041100
  ident: 2004534815
– year: 20030700
  ident: 1323710
– year: 20050600
  ident: WO 2005/058849
– year: 20020500
  ident: WO 02/42461
– year: 20060300
  ident: 1638950
– year: 20050200
  ident: 2005/0043292
  contributor:
    fullname: Parker et al.
– year: 19990800
  ident: WO 9938501
– year: 20060400
  ident: WO 2006/043490
– year: 20040400
  ident: 2004/0063935
  contributor:
    fullname: Yasuda et al.
– year: 20030100
  ident: WO 03/002593
– year: 20031200
  ident: WO 03/105763
– year: 20030100
  ident: WO 03/002596
– year: 20030700
  ident: WO 03/057666
– year: 20030800
  ident: 2003/0162820
  contributor:
    fullname: Demuth et al.
– year: 20061000
  ident: 7122555
  contributor:
    fullname: Boehringer et al.
– year: 20030500
  ident: WO 03/035067
– year: 20060500
  ident: 1659123
– year: 20051200
  ident: WO 2005/116014
– year: 20031000
  ident: 2003/0199528
  contributor:
    fullname: Kanstrup et al.
– year: 19981100
  ident: WO 98/50066
– year: 20040600
  ident: 2004/0116328
  contributor:
    fullname: Yoshikawa et al.
– year: 20050300
  ident: 1517907
– year: 20060500
  ident: 2006/0111336
  contributor:
    fullname: Duffy et al.
– year: 20040600
  ident: WO 2004/050022
– year: 20010400
  ident: 6221660
  contributor:
    fullname: Bonini et al.
– year: 20041200
  ident: WO 2004/103276
– year: 20011200
  ident: WO 01/96295
– year: 20040800
  ident: WO 2004/069162
– year: 19971100
  ident: WO 97/40832
– year: 20070300
  ident: 2007/0072844
  contributor:
    fullname: Jones et al.
– year: 20060300
  ident: 1638968
– year: 19810300
  ident: 4256108
  contributor:
    fullname: Teeuwes et al.
– year: 20040200
  ident: 2004043429
– year: 20020200
  ident: WO 02/14271
– year: 20020600
  ident: 6410508
  contributor:
    fullname: Isales et al.
– year: 20060100
  ident: 2006/0014764
  contributor:
    fullname: Feng et al.
– year: 20000300
  ident: 2339537
– year: 20040600
  ident: 1426366
– year: 20040300
  ident: 1399469
– year: 20020600
  ident: WO 02/44362
– year: 20050900
  ident: 6946480
  contributor:
    fullname: Demuth et al.
– year: 20001000
  ident: 1043328
– year: 20041200
  ident: 2004/0259902
  contributor:
    fullname: Boehringer et al.
– year: 20000900
  ident: 2000511559
– year: 19991200
  ident: WO 99/67278
– year: 20050100
  ident: 6844316
  contributor:
    fullname: Niestroj et al.
– year: 20040300
  ident: 10238470
– year: 20040700
  ident: WO 2004/058266
– year: 20060200
  ident: WO 2006/011035
– year: 20060700
  ident: 7074798
  contributor:
    fullname: Yoshikawa et al.
– year: 20030900
  ident: WO 03/074500
– year: 20060600
  ident: 1664031
– year: 20010400
  ident: 1092727
– year: 20050500
  ident: WO 2005/044195
– year: 20040100
  ident: 2004002368
– year: 20021200
  ident: 2002/0183367
  contributor:
    fullname: Sulsky et al.
– year: 20040600
  ident: WO 2004/048379
– year: 20050200
  ident: WO 2005/012249
– year: 20011100
  ident: WO 01/87929
– year: 20071000
  ident: WO 2007/116230
– year: 20040400
  ident: 1406622
– year: 20000800
  ident: WO 00/50562
– year: 20040300
  ident: 6699871
  contributor:
    fullname: Edmondson et al.
– year: 20020200
  ident: 1282600
– year: 20060400
  ident: WO 2006/040966
– year: 20031200
  ident: WO 03/099279
– year: 20050500
  ident: WO 2005/047297
– year: 20020800
  ident: 2002527504
– year: 20041200
  ident: WO 2004/112701
– year: 20040600
  ident: 2004/0110817
  contributor:
    fullname: Hulin et al.
– year: 20001100
  ident: WO 00/71135
– year: 20040600
  ident: WO 2004/050658
– year: 20030400
  ident: WO 03/026661
– year: 20040600
  ident: 2004/0106656
  contributor:
    fullname: Ashton et al.
– year: 20020500
  ident: WO 02/38541
– year: 20050400
  ident: WO 2005/037779
– year: 20050300
  ident: WO 2005/019168
– year: 20030400
  ident: 2003/0078247
  contributor:
    fullname: DeNanteuil et al.
– year: 20030800
  ident: 2003524591
– year: 20040900
  ident: 2004/0180925
  contributor:
    fullname: Matsuno et al.
– year: 20080300
  ident: 1902730
– year: 20020400
  ident: WO 02/30891
– year: 20080300
  ident: WO2008/025798
– year: 20040400
  ident: 2004/0072892
  contributor:
    fullname: Fukushima et al.
– year: 20060600
  ident: 1667524
– year: 20040700
  ident: 2004/0138214
  contributor:
    fullname: Himmelsbach et al.
– year: 20050900
  ident: WO 2005/082348
– year: 20001100
  ident: 1050540
– year: 20050100
  ident: WO 2005/007647
– year: 20010600
  ident: 6242422
  contributor:
    fullname: Karanewsky
– year: 20011100
  ident: WO 01/81337
– year: 20060500
  ident: 7053055
  contributor:
    fullname: Demuth et al.
– year: 20050100
  ident: WO 2005/000846
– year: 20040300
  ident: 1399433
– year: 20080300
  ident: 2008/0058339
  contributor:
    fullname: Brandt et al.
– year: 19980500
  ident: WO 98/18763
– year: 20041000
  ident: 6800650
  contributor:
    fullname: Boehringer et al.
– year: 20040400
  ident: 1304327
– year: 20030100
  ident: WO 03/002530
– year: 20040400
  ident: 1412357
– year: 20040900
  ident: 2004269468
– year: 20040400
  ident: WO 2004/033455
– year: 20040900
  ident: 1461337
– year: 20000900
  ident: WO 00/56296
– year: 20031000
  ident: WO 03/082817
– year: 19911100
  ident: 296075
– year: 20030800
  ident: 1338592
– year: 20030100
  ident: WO 03/004496
– year: 20041100
  ident: WO 2004/099134
– year: 20040100
  ident: 2004026678
– year: 20071000
  ident: WO 2007/116229
– year: 20060100
  ident: WO 2006/009886
– year: 20030700
  ident: 2003/0130199
  contributor:
    fullname: Von Hoersten et al.
– year: 20041000
  ident: 6803357
  contributor:
    fullname: Bachovchin et al.
– year: 20031200
  ident: 2003/0225102
  contributor:
    fullname: Sankaranarayanan et al.
– year: 20041200
  ident: 1480961
– year: 19991200
  ident: WO 99/61431
– year: 20040800
  ident: 1441719
– year: 20020400
  ident: 1261586
– year: 19950200
  ident: 1995501078
– year: 20050600
  ident: WO 2005/058901
– year: 20040300
  ident: 1399470
– year: 20060600
  ident: 2006/0142262
  contributor:
    fullname: Jones et al.
– year: 20020800
  ident: 2002/0103384
  contributor:
    fullname: Kanstrup et al.
– year: 20011000
  ident: 1137635
– year: 20020900
  ident: 2002531547
– year: 20000200
  ident: 0980249
– year: 20060400
  ident: 7022718
  contributor:
    fullname: Boehringer et al.
– year: 20040900
  ident: 2004/0176406
  contributor:
    fullname: Gobbi et al.
– year: 20060600
  ident: 2006/0135767
  contributor:
    fullname: Feng et al.
– year: 20031200
  ident: WO 03/106456
– year: 20041200
  ident: WO2004/111051
– year: 20010800
  ident: 1123272
– year: 20060300
  ident: 1635818
– year: 20031000
  ident: WO 03/080633
– year: 20040700
  ident: 2004522786
– year: 19981100
  ident: 2289125
– year: 20030900
  ident: WO 03/072528
– year: 20030600
  ident: 6573287
  contributor:
    fullname: Sulsky et al.
– year: 20030700
  ident: 2003/0134802
  contributor:
    fullname: Demuth et al.
– year: 20010700
  ident: WO 01/52825
– year: 20031100
  ident: 6653064
  contributor:
    fullname: Jochum et al.
– year: 20050100
  ident: WO 2005/007658
– year: 20081200
  ident: 7470699
  contributor:
    fullname: Jones et al.
– year: 20060300
  ident: 1638970
– year: 20030700
  ident: 2003520849
– year: 20040900
  ident: 1450794
– year: 20050100
  ident: 2005502624
– year: 20061100
  ident: 7132426
  contributor:
    fullname: Jones et al.
– year: 20050300
  ident: 2005/0059650
  contributor:
    fullname: Jones et al.
– year: 20060200
  ident: 1624874
– year: 20050900
  ident: WO 2005/085246
– year: 20041000
  ident: WO 2004/085378
– year: 20040600
  ident: 10256264
– year: 20030100
  ident: WO 03/002595
– year: 20031200
  ident: WO 03/101958
– year: 20000100
  ident: 19828113
– year: 20050200
  ident: 10333935
– year: 20021100
  ident: 1254113
– year: 19911000
  ident: WO 91/16339
– year: 20011100
  ident: WO 01/81304
– year: 20040400
  ident: 2004/0077645
  contributor:
    fullname: Himmelsbach et al.
– year: 20030700
  ident: 2003/0125539
  contributor:
    fullname: Bonini et al.
– year: 20060600
  ident: 2006/0142576
  contributor:
    fullname: Meng et al.
– year: 20000400
  ident: 0995440
– year: 20020600
  ident: 1215207
– year: 20040900
  ident: 2004269469
– year: 20041200
  ident: WO 2004/111041
– year: 20000500
  ident: WO 02/34900
– year: 20050900
  ident: 6949515
  contributor:
    fullname: Demuth et al.
– year: 20080100
  ident: WO 2008/005576
– year: 20020700
  ident: WO 02/051836
– year: 19971000
  ident: 1997509921
– year: 20031100
  ident: 2003327532
– year: 20050300
  ident: 6861440
  contributor:
    fullname: Boehringer et al.
– year: 20050700
  ident: WO 2005/061489
– year: 20050300
  ident: 2005507261
– year: 20031200
  ident: 2003/0232788
  contributor:
    fullname: Karanewsky et al.
– year: 20020900
  ident: WO 02/068420
– year: 20090200
  ident: 2009/0036434
  contributor:
    fullname: Jones et al.
– year: 20000600
  ident: WO 00/34241
– year: 20050500
  ident: 6897222
  contributor:
    fullname: Gobbi et al.
– year: 19991200
  ident: 19823831
– year: 20050300
  ident: 2005/0070562
  contributor:
    fullname: Jones et al.
– year: 20051200
  ident: WO 2005/115982
– year: 20070100
  ident: WO 2007/003964
– year: 20070100
  ident: WO 2007/003962
– year: 20060200
  ident: 2006/0039974
  contributor:
    fullname: Akiyama et al.
– year: 20031100
  ident: 2003535034
– year: 20040700
  ident: 2004521149
– year: 20040500
  ident: WO 2004/041820
– year: 20030500
  ident: WO 03/038123
– year: 20030300
  ident: WO 03/024965
– year: 20100100
  ident: WO 2010/001166
– year: 20030100
  ident: WO 03/002531
– year: 20060400
  ident: 7026316
  contributor:
    fullname: Ashton et al.
– year: 20060300
  ident: WO 2006/023750
– year: 20041100
  ident: 2004535433
– year: 20060900
  ident: 2006/0217379
  contributor:
    fullname: Jones et al.
– year: 20041000
  ident: WO 2004/087053
– year: 20080300
  ident: WO2008/025800
– year: 19950600
  ident: WO 95/15309
– year: 20060300
  ident: 7008957
  contributor:
    fullname: Wagner et al.
– year: 20070700
  ident: 2007/0167473
  contributor:
    fullname: Jones et al.
– year: 20030100
  ident: WO 03/000250
– year: 20040200
  ident: 2004503531
– year: 20090200
  ident: 7495002
  contributor:
    fullname: Langkopf et al.
– year: 20040500
  ident: 2004/0097510
  contributor:
    fullname: Himmelsbach et al.
– year: 20060500
  ident: WO 2006/047248
– year: 20050300
  ident: 6869947
  contributor:
    fullname: Kanstrup et al.
– year: 20030500
  ident: WO 03/040174
– year: 20040100
  ident: WO 2004/009544
– year: 20050600
  ident: WO 2005/049022
– year: 20041100
  ident: WO2004/096806
– year: 20040400
  ident: 6716843
  contributor:
    fullname: de Nanteuil et al.
– year: 20060200
  ident: WO2006/015699
– year: 20050300
  ident: 6867205
  contributor:
    fullname: Boehringer et al.
– year: 20080300
  ident: WO2008/025799
– year: 20031200
  ident: 2003535898
– year: 20040300
  ident: 6710040
  contributor:
    fullname: Hulin et al.
– year: 20050500
  ident: WO 2005/042488
– year: 20030800
  ident: 1338651
– year: 20041000
  ident: 1469873
– year: 20020100
  ident: 2002/0006899
  contributor:
    fullname: Pospisilik et al.
– year: 20030800
  ident: 2003238566
– year: 20041100
  ident: 1476429
– year: 20040800
  ident: 1446116
– year: 20040400
  ident: 1406872
– year: 19980700
  ident: 1998182613
– year: 20040300
  ident: WO 2004/020407
– year: 20041000
  ident: 1463727
– year: 20060800
  ident: 7083933
  contributor:
    fullname: Griffin et al.
– year: 20070300
  ident: 2007/0066590
  contributor:
    fullname: Jones et al.
– year: 20040900
  ident: 2004244412
– year: 20001100
  ident: WO 00/56297
– year: 19951000
  ident: 5462856
  contributor:
    fullname: Lerner et al.
– year: 20100100
  ident: 7645763
  contributor:
    fullname: Himmelsbach et al.
– year: 19981100
  ident: 2289124
– year: 20040800
  ident: WO 2004/071454
– year: 20040100
  ident: 2004002367
– year: 20030800
  ident: 1333025
– year: 20031000
  ident: WO 03/084940
– year: 20030400
  ident: WO 03/002661
– year: 20031000
  ident: 1355886
– year: 20050400
  ident: WO 2005/030127
– year: 20030500
  ident: 2003/0087950
  contributor:
    fullname: DeNanteuil et al.
– year: 20030300
  ident: WO 03/022871
– year: 20070200
  ident: 2007/0032420
  contributor:
    fullname: Polidori et al.
– year: 20021100
  ident: 2824825
– year: 20050200
  ident: 2005/0032804
  contributor:
    fullname: Cypes et al.
– year: 20020800
  ident: 1228061
– year: 19991200
  ident: WO 99/62914
– year: 20021000
  ident: WO 02/083128
– year: 20060300
  ident: 2006/0069116
  contributor:
    fullname: Ashton et al.
– year: 20050100
  ident: 1492777
– year: 20030700
  ident: WO 03/057144
– year: 20050100
  ident: WO 2005/000848
– year: 20041200
  ident: 2004/0242898
  contributor:
    fullname: Hulin et al.
– year: 20071200
  ident: WO 2007/138362
– year: 20040800
  ident: WO 2004/064778
– year: 20040900
  ident: WO 2004/076434
– year: 20020700
  ident: WO 02/055088
– year: 20060600
  ident: WO 2006/058064
– year: 20060300
  ident: WO 2006/030847
– year: 20011000
  ident: 6303661
  contributor:
    fullname: Demuth et al.
– year: 20031000
  ident: 2003531118
– year: 19991100
  ident: WO 99/56753
– year: 20021000
  ident: WO 02/083109
– year: 19930300
  ident: 0528858
– year: 20021000
  ident: 1248604
– year: 20040300
  ident: 1399471
– year: 20051200
  ident: WO 2005/123685
– year: 20060600
  ident: WO 2006/058628
– year: 20060200
  ident: WO 2006/013104
– year: 20060200
  ident: WO 2006/012395
– year: 20080600
  ident: WO 2008076243
– year: 20060500
  ident: 1658066
– year: 20010500
  ident: WO 01/34594
– year: 20041100
  ident: 6812350
  contributor:
    fullname: Hulin et al.
– year: 20020400
  ident: 6380398
  contributor:
    fullname: Kanstrup et al.
– year: 20021000
  ident: 6468756
  contributor:
    fullname: Bonini et al.
– year: 20030500
  ident: WO 03/035057
– year: 20040100
  ident: WO 2004/024943
– year: 20060800
  ident: WO 2006/086727
– year: 20060600
  ident: WO 2006/068978
– year: 20050200
  ident: 6849622
  contributor:
    fullname: Yasuda et al.
– year: 20040300
  ident: WO 2004/018467
– year: 20021000
  ident: WO 02/076450
– year: 20041000
  ident: 2004532220
– year: 20040300
  ident: 6706742
  contributor:
    fullname: de Nanteuil et al.
– year: 19930500
  ident: WO 93/10127
– year: 19980300
  ident: 1998081666
– year: 20030700
  ident: 2003/0125304
  contributor:
    fullname: Demuth et al.
– year: 20040200
  ident: 1385508
– year: 20040800
  ident: WO2004/067509
– year: 20050300
  ident: WO 2005/026148
– year: 20041100
  ident: 2004535445
– year: 20041000
  ident: WO 2004/085661
– year: 20050400
  ident: WO 2005/034940
– year: 20050300
  ident: 2005/0059724
  contributor:
    fullname: Schoenafinger et al.
– year: 19981100
  ident: WO 98/50046
– year: 20030600
  ident: 2003/0119750
  contributor:
    fullname: Demuth et al.
– year: 20041100
  ident: 2004315496
– year: 20020600
  ident: 2002516318
– year: 20010800
  ident: WO 01/55105
– year: 20041200
  ident: 2004/0254226
  contributor:
    fullname: Feng et al.
– year: 19990300
  ident: WO 99/14344
– year: 20020700
  ident: 2433090
– year: 20030400
  ident: 1296974
– year: 20070300
  ident: 2007/0072804
  contributor:
    fullname: Chu et al.
– year: 20050100
  ident: WO 2005/003135
– year: 20030700
  ident: 2003/0130281
  contributor:
    fullname: Boehringer et al.
– year: 20040800
  ident: 2004525179
– year: 20041100
  ident: 2004/0229926
  contributor:
    fullname: Yasuda et al.
– year: 20021200
  ident: 2002/0198205
  contributor:
    fullname: Himmelsbach et al.
– year: 20031200
  ident: WO 04/000327
– year: 20050100
  ident: 2005500308
– year: 20051200
  ident: WO 2005/120494
– year: 20091000
  ident: 2009/0253153
  contributor:
    fullname: Chu et al.
– year: 20020800
  ident: WO 02/062764
– year: 20050300
  ident: WO 2005/020920
– year: 20050400
  ident: WO 2005/030751
– year: 20050900
  ident: WO 2005/087235
– year: 20020500
  ident: 6395767
  contributor:
    fullname: Robl et al.
– year: 20071000
  ident: WO 2007/120689
– year: 20060300
  ident: WO 2006/033848
– year: 20051000
  ident: WO 2005/100334
– year: 20031100
  ident: 2003/0216382
  contributor:
    fullname: Boehringer et al.
– year: 20050900
  ident: WO 2005/082849
– year: 20030200
  ident: 1280797
– year: 20030300
  ident: WO 03/024942
– year: 19931200
  ident: 1993508624
– year: 20060200
  ident: 1625122
– year: 20051000
  ident: WO 2005/095339
– year: 20070300
  ident: WO 2007/035355
– year: 19940800
  ident: 0610317
– year: 20020600
  ident: WO 02/49648
– year: 20000200
  ident: 19834591
– year: 20000400
  ident: 6051386
  contributor:
    fullname: Lerner et al.
– year: 20000900
  ident: WO 00/53171
– year: 20031000
  ident: 2003300977
– year: 20040100
  ident: WO 2004/004661
– year: 20040800
  ident: WO 2004/065380
– year: 20000700
  ident: 2000191616
– year: 20051200
  ident: WO 2005/121121
– year: 20030600
  ident: WO 03/045228
– year: 19990500
  ident: WO 99/25719
– year: 20010700
  ident: 2001510442
– year: 20051200
  ident: WO 2005/118555
– year: 20010600
  ident: 1104293
– year: 20050100
  ident: 2005/0004205
  contributor:
    fullname: Evans et al.
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Snippet The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the...
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Title Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level
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