Compounds

Heterocyclic amides useful as inhibitors of dipeptylpeptidase-IV (DPP-IV) enzyme, process for the preparation thereof and intermediates therefore.

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Main Authors Arányi, Péter, Balázs, László, Bata, Imre, Bátori, Sándor, Boronkay, Éva, Kapui, Zoltán, Susán, Edit, Szabó, Tibor, Nagy, Lajos T, Urbán-Szabó, Katalin, Varga, Márton
Format Patent
LanguageEnglish
Published 24.08.2010
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Abstract Heterocyclic amides useful as inhibitors of dipeptylpeptidase-IV (DPP-IV) enzyme, process for the preparation thereof and intermediates therefore.
AbstractList Heterocyclic amides useful as inhibitors of dipeptylpeptidase-IV (DPP-IV) enzyme, process for the preparation thereof and intermediates therefore.
Author Arányi, Péter
Bátori, Sándor
Varga, Márton
Boronkay, Éva
Szabó, Tibor
Urbán-Szabó, Katalin
Bata, Imre
Balázs, László
Nagy, Lajos T
Kapui, Zoltán
Susán, Edit
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References (1 323 710) 20030700
Mayer, S.C., et al; "Synthesis of New Didemnin B Analogs for Investigations of Structure/Biological Activity Relationships"; Journal of Medicinal Chemistry, 1994, vol. 59, No. 18, pp. 5192-5205.
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Conti, S., et al; "Chiral Ligands Containing Heteroatoms:13.1 Optically Active 4-(2′-Pyridyl)1,3-oxazolidines: an Improved Synthesis of 2-(2′-Pyridy1)-2-aminoalcohols"; Tetrahedron, 1994, vol. 50, No. 47, pp. 13493-13500.
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Villhauer, E.B., et al; "1-[2-{(5-Cyanopyridin-2-yl)amino]ethylamino}acetyl-2-(S)-pyrrolidine-carbonnitrile: A Potent, Selective, and Orally Bioavailable Dipeptidyl Peptidase IV Inhibitor with Antihyperglycemic Properties"; Journal of Medicinal Chemistry, 2002, vol. 45, No. 12, pp. 2362-2365.
Kiely, J.S., et al; "Quinolone Antibacterials: Preparation and Activity of Bridged Bicyclic Analogues of the C7-Piperazine"; Journal of Medicinal Chemistry, 1991, vol. 34, No. 2, pp. 656-663.
(WO 01/96295) 20011200
Mach, R.H., et al; "18F-Labeled Benzamides for Studying the Dopamine D2 Receptor with Positron Emission Tomography"; Journal of Medicinal Chemistry, 1993, vol. 36, No. 23, pp. 3707-3720.
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Kitchin, J., et al; Synthesis and Structure-Activity Relationships of a Series of Penicillin-Derived HIV Proteinase Inhibitors: Heterocyclic Ring Systems Containing P1′ and P2′ Substituents; Journal of Medicinal Chemistry, 1994, vol. 37, No. 22, pp. 3707-3716.
(WO 03/074500) 20031200
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