Cyclopropyl aryl amide derivatives and uses thereof

121 2 Compounds of the formula: wherein Ar, Ar, Rand Rare as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.

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Main Authors Du Bois, Daisy Joe, Loughhead, David Garrett, Maag, Hans, Manka, Jason, Smith, David Bernard, Hurst, David Nigel
Format Patent
LanguageEnglish
Published 25.05.2010
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Abstract 121 2 Compounds of the formula: wherein Ar, Ar, Rand Rare as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.
AbstractList 121 2 Compounds of the formula: wherein Ar, Ar, Rand Rare as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.
Author Hurst, David Nigel
Manka, Jason
Loughhead, David Garrett
Smith, David Bernard
Du Bois, Daisy Joe
Maag, Hans
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References (WO 00/42034) 20000700
(WO 2005/087744) 20050900
Goldstein et al. (2003/0191279) 20031000
(WO 2005/012253) 20050200
(WO 2004/018431) 20040300
(WO 2005/090311) 20050900
(WO 2007/039173) 20070400
(WO 02/06239) 20020100
Wolf et al., Enantioseparations by electrochematography with packed capillaries, 1997, Journal of Chromatography A., 782, pp. 175-179.
Bhagwat et al. (2005/0009876) 20050100
(WO 00/42017) 20000700
(WO 02/072090) 20020900
(WO 99/27783) 19990600
(WO 2004/019944) 20040300
(WO 01/51470) 20010700
(WO 2005/077906) 20050800
(WO 99/05115) 19990200
Bhagwat et al. (2004/0127536) 20040700
Bondon, A., et. al. "Oxidation of Cycloalkylamines by Cytochrome P-450," The Journal of Biological Chemistry, 1989, vol. 264 (4), pp. 1988-1997.
Lu et al. (4694016) 19870900
(WO 2005/012252) 20050200
(WO 03/018536) 20030300
White, W. L., et. al. New Reactions of Polyfluoroaromatic Compounds. Part II. † Polyfluoroaralkyl Amines1 J. American Chemical Soc. 1971, pp. 2062-2068.
(WO 00/42020) 20000700
(1 388 535) 20040200
(WO 2005/087745) 20050900
Vlaeminck, F. et. al. "Benzo- and Indoloquinolizidines. Part XVIII. The Preparation of 4b,5,6,7,7°,9,10,14b-Octahydrodibenzo[a,h]Cyclopenta [c] Quinolizine Isomers. An Application of Stereoselective Iminium Cyclisations." Heterocycles 1979, vol. 12 (3), pp. 329-335.
(1 088 819) 20050600
Caldwell et al. (5750549) 19980500
(WO 02/06238) 20020100
(WO 2004/009610) 20040100
(WO 01/44213) 20010600
Nambu et al. (2007/0167497) 20070700
(WO 02/05616) 20020100
(0 284 174) 19920700
(WO 00/42018) 20000700
(WO 2005/085203) 20050900
Biel et al. (3192229) 19650600
(WO 99/05111) 19990200
Brown, R. S., et. al. "Substituent Effects on σ- Conjugation. The Absence of Electron Transmission through Cyclopropane Rings1,2" J. American Chemical Soc. 1973, pp. 8025-8032.
Burger, A., et. al. "Arylcyloalkylamines. I. 2-Phenylcyclopropylamine," J. American Chemical Soc. 1948, vol. 70, pp. 2198-2201.
(WO 2004/081011) 20040900
(WO 2007/134799) 20071100
(WO 2004/093799) 20041100
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Snippet 121 2 Compounds of the formula: wherein Ar, Ar, Rand Rare as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of...
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Title Cyclopropyl aryl amide derivatives and uses thereof
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