Vector
A vector comprising a nucleotide sequence of interest ("NOI") encoding a product of interest ("POI") is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.
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| Main Authors | , , , , |
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| Format | Patent |
| Language | English |
| Published |
18.05.2010
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| Online Access | Get full text |
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| Abstract | A vector comprising a nucleotide sequence of interest ("NOI") encoding a product of interest ("POI") is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor. |
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| AbstractList | A vector comprising a nucleotide sequence of interest ("NOI") encoding a product of interest ("POI") is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor. |
| Author | Kingsman, Susan M Bebbington, Christopher R Carroll, Miles W Myers, Kevin A Ellard, Fiona M |
| Author_xml | – sequence: 1 givenname: Susan M surname: Kingsman fullname: Kingsman, Susan M – sequence: 2 givenname: Christopher R surname: Bebbington fullname: Bebbington, Christopher R – sequence: 3 givenname: Fiona M surname: Ellard fullname: Ellard, Fiona M – sequence: 4 givenname: Miles W surname: Carroll fullname: Carroll, Miles W – sequence: 5 givenname: Kevin A surname: Myers fullname: Myers, Kevin A |
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"A phase I study of recombinant adenovirus vector-mediated delivery of an anti-erbB-2 single-chain (sFv) antibody gene for previously treated ovarian and extraovarian cancer patients", Human Gene Therapy (1997) 8(2):229-242. Myers, Kevin A., et al. "Isolation of a cDNA Encoding 5T4 Oncofetal Trophoblast Glycoprotein", The Journal of Biological Chemistry (1994) 269(12):9319-9324. Jannot, C.B., et al. "Intracellular Expression of a Single-Chain Antibody Directed to the EGFR Leads to Growth Inhibition of Tumor Cells", Oncogene (1998) 13(2):275-282. Mullins, John H., et al. "Transgenesis in Nonmurine Species", Hypertension (1993) 22:630-633. Kingsman et al. (7074909) 20060700 |
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