Triazolo-quinolin derivatives useful as adenosine receptor ligands

3 The present invention relates to adenosine Areceptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I), as well as their...

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Main Authors Aranyi, Peter, Balazs, Laszlo, Batori, Sandor, Bence, Judit, Boer, Kinga, Hajdu, Felix, Kapui, Zoltan, Mikus, Endre, Szabo, Tibor, Nagy, Lajos T, Timari, Geza, Urban-Szabo, Katalin, Walcz, Erzsebet
Format Patent
LanguageEnglish
Published 11.05.2010
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Abstract 3 The present invention relates to adenosine Areceptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I), as well as their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers, furthermore to the new intermediates of the general formulae (II) and to the preparation thereof.
AbstractList 3 The present invention relates to adenosine Areceptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I), as well as their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers, furthermore to the new intermediates of the general formulae (II) and to the preparation thereof.
Author Timari, Geza
Balazs, Laszlo
Aranyi, Peter
Mikus, Endre
Batori, Sandor
Hajdu, Felix
Szabo, Tibor
Kapui, Zoltan
Boer, Kinga
Walcz, Erzsebet
Bence, Judit
Nagy, Lajos T
Urban-Szabo, Katalin
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References Winters et al. (4024149) 19770500
Aranyi (7365089) 20080400
Vippagunta et al., Advanced Drug Delivery Reviews, p. 1.
Brown, R., et al., The Pyrolytic Rearrangement of 1-Alkynoyl-3-Methylpyrazoles: Synthesis, Chemical Abstract. No. 121:108613 (1994).
Potts, K., et al., 1,2,4-Triazoles. XIII. Derivatives of the s-Triazolo[1,5-a]pyridine Ring System, J. Org. Chem., vol. 31, No. 3, pp. 260-265 (1966).
Schefczik et al. (5101028) 19920300
Hubler, D. et al., Prodn. of Triazolopyridine-Carbo-Nitrile Derivs. Useful as Cardiovascular Agents with Positive Inotropic Activity, Derwent Patent Abstract No. 199047 (2004).
(280110) 19900600
Brown, R., et al., N-Alkylation and Electrophilic Substitution Reactions of 2-Methylpyrazolo [1,5-a] pyridin-5-ol and Related Compounds;Chemical Abstract No. 121:134019 (1994).
Selby, T, et al., 7-Phenyl-1,2,4-triazolo [1,5-a] Pyrimidines and Related Heterocycles. A New Family of Bleaching Herbicides., Chemical Abstract No. 118:2390 (1992).
(280109) 19900600
Vippagunta et al., Advanced Drug Delivery Reviews, 2001, vol. 48, 3-26.
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