Imidazopyridine-derivatives as inducible no-synthase inhibitors
The compounds of formula (I) in which R1, R2, R3, R4, R5 and A have the meanings as given in the description are novel effective iNOS inhibitors.
Saved in:
Main Author | |
---|---|
Format | Patent |
Language | English |
Published |
04.05.2010
|
Online Access | Get full text |
Cover
Loading…
Abstract | The compounds of formula (I) in which R1, R2, R3, R4, R5 and A have the meanings as given in the description are novel effective iNOS inhibitors. |
---|---|
AbstractList | The compounds of formula (I) in which R1, R2, R3, R4, R5 and A have the meanings as given in the description are novel effective iNOS inhibitors. |
Author | Ulrich, Wolf-Ruediger |
Author_xml | – sequence: 1 givenname: Wolf-Ruediger surname: Ulrich fullname: Ulrich, Wolf-Ruediger |
BookMark | eNrjYmDJy89L5WSw98zNTEmsyi-oLMpMycxL1U1JLcosSyzJLEstVkgsVsjMSylNzkzKSVXIy9ctrswryUgsTgWKZmQmZZbkFxXzMLCmJeYUp_JCaW4GBTfXEGcP3dLigsSS1LyS4vj0okQQZWBubmBpYmFhTIQSAOG-NKM |
ContentType | Patent |
CorporateAuthor | Altana Pharma AG |
CorporateAuthor_xml | – name: Altana Pharma AG |
DBID | EFH |
DatabaseName | USPTO Issued Patents |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EFH name: USPTO Issued Patents url: http://www.uspto.gov/patft/index.html sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
ExternalDocumentID | 07709488 |
GroupedDBID | EFH |
ID | FETCH-uspatents_grants_077094883 |
IEDL.DBID | EFH |
IngestDate | Sun Mar 05 22:42:41 EST 2023 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-uspatents_grants_077094883 |
OpenAccessLink | https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7709488 |
ParticipantIDs | uspatents_grants_07709488 |
PatentNumber | 7709488 |
PublicationCentury | 2000 |
PublicationDate | 20100504 |
PublicationDateYYYYMMDD | 2010-05-04 |
PublicationDate_xml | – month: 05 year: 2010 text: 20100504 day: 04 |
PublicationDecade | 2010 |
PublicationYear | 2010 |
References | Salvemini, et al., "Dual inhibition of Nitric Oxide and Prostaglandin Production Contributes to the Antiinflammatory Properties of Nitric Oxide Synthase Inhibitors", J. Clin. Invest., vol. 96, pp. 301-308, (1995). Ulrich (7279488) 20071000 D'Agostino, P., et al., "Tetracycline inhibits the nitric oxide synthase activity induced by endotoxin in cultured murine macrophages", European Journal of Pharmacology, vol. 346, pp. 283-290, (1998). (97/25030) 19970700 (2005/030769) 20050400 (0 125 756) 19841100 Lidia, et al., "Prostaglandins and nitric oxide as molecular targets for anti-inflammatory therapy", Fitoterapia, vol. 71, pp. S48-S57, (2000). Kiss, J., et al., "Time-dependent actions of nitric oxide synthase inhibition on colonic inflammation induced by trinitrobenzene sulphonic acid in rats", European Journal of Pharmacology, vol. 336, pp. 219-224, (1997). (2005/061496) 20050700 (25 04 252) 19750800 Tinker, et al., "1,2-dihydro-4-quinazolinamines: Potent Highly Selective Inhibitors of Inducible Nitric Oxide Synthase Which Show Antiinflammatory Activity in vivo", J. Med. Chem, vol. 469 pp. 913-916, (2003). Hua, L. L., et al., "Role of mitogen-activated protein kinases in inducible nitric oxide synthase and TNFα expression in human fetal astrocytes", Journal of Neuroimmunology, vol. 126, pp. 180-189, (2002). Hickey et al., Clinical Science (2001), 1-12. Kankuri, et al., "Suppression of Acute Experimental Colitis by a Highly Selective Inducible Nitric-Oxide Synthase Inhibitor, N-[3-(Aminomethyl)benzy]acetamidine", JPET, vol. 298, pp. 1128-1132, (2001). Kim, M-S., et al., "Water-soluble chitosan inhibits the production of pro-inflammatory cytokine in human astrocytoma cells activated by amyloid β peptide and interleukin-1β", Neuroscience Letters, vol. 321, pp. 105-109, (2002). (2005/030771) 20040400 Ulrich (7468377) 20081200 Ohtsuka, et al., "PPA250 {3-(2,4-difluoropheny1)-6-{2-[4-(1H-imdazol-1-ylmethyl)Phenoxy]ethoxy}-2-phenylpyridine], a Novel Orally Effective Inhibitor of the Dimerization of Inducible Nitric-Oxide Synthase, Exhibits an Anti-inflammatory Effect in Animal Models of Chronic Arthritis", JPET, vol. 303, pp. 52-57, (2002). (2005/030768) 20050400 Liu, et al., "Specificity of inducible nitric-oxide synthase inhibitors: prospects for their clinical therapy", Acta Pharmacol. Sin,, vol. 20, No. 11, pp. 1052-1056, (1999). Hansel, et al., "A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics", FASEB J, vol. 17, pp. 1298-1300, (2003). Ulrich (7138399) 20061100 (03/080607) 20031000 (00/49015) 20000800 Cuzzocrea, et al., "Beneficial effects of GW274150, a novel, potent and selective inhibitor of iNOS activity, in a rodent model of collagen-induced arthritis", Eur. J. Pharm., vol. 453, pp. 119-129, (2002). Berntsson et al. (4045564) 19770800 |
References_xml | – year: 19841100 ident: 0 125 756 – year: 19770800 ident: 4045564 contributor: fullname: Berntsson et al. – year: 19750800 ident: 25 04 252 – year: 20050400 ident: 2005/030768 – year: 20071000 ident: 7279488 contributor: fullname: Ulrich – year: 20050700 ident: 2005/061496 – year: 20031000 ident: 03/080607 – year: 20061100 ident: 7138399 contributor: fullname: Ulrich – year: 20050400 ident: 2005/030769 – year: 20040400 ident: 2005/030771 – year: 19970700 ident: 97/25030 – year: 20081200 ident: 7468377 contributor: fullname: Ulrich – year: 20000800 ident: 00/49015 |
Score | 2.774986 |
Snippet | The compounds of formula (I) in which R1, R2, R3, R4, R5 and A have the meanings as given in the description are novel effective iNOS inhibitors. |
SourceID | uspatents |
SourceType | Open Access Repository |
Title | Imidazopyridine-derivatives as inducible no-synthase inhibitors |
URI | https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7709488 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT8MwDLa2CQk4gQAxXuqBa6BaX9mJA1pVkEA7gLTblDQOq7SlVdOCxq_H6WDiApccHMmxYtmfrdgOwDXyINd-rlmoEWkZaTYexZJxRfCphNQycM3JT89x9ho-zqJZD7JtL8yKzIhVJIu9aW3VlF1xJbn3jeLZZvizmxFo3PSBD7MshZoqfZsklKhw3oc-911p1yTN9mGXWFDIZhr7CzTSA9iZdtRD6KE5gruHVaHEZ1mt64IAA5ki5b93c7etJ6xHyXGbF3KJnimZXZtmQQBD1EUhC_clzjF46eTlPmPb0-ZvtatimfvfUgUnMKBsHk_BkyjiBCXn0RjJfnyR6JC8RigTFQkKHocw_JPN2T9757D387DthxcwaOoWLwkvG3nVXcYX9H54_g |
link.rule.ids | 230,309,786,808,891,64394 |
linkProvider | USPTO |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV07T8MwED6VgnhMIEAtzwyshqh5dmKARimPKgNI3SI7tmmk1oniBFR-PecUKhZYPJyl88kn33cn-z4DXInQyaSdSeJKIXAYSDIc-IyEHOGTUyaZY5qTnyd-_Oo-TL1pB-J1L8wCjxEp0RZ93eiyLtrHlRjeV44nK_JnwxGoDPvAh5oXlCdc3gQBFiphuAGbBmMNi_4oivdgB5Vg0qZq_Qs2on3YSlrpAXSEOoTb8SLn9LMol1WOkCEIR_e_t8zb2qLawvK4yXI2F5YqiF6qeoYQg9JZznLzKc4RWNHo5S4m69XSt8q8Y0ntb7ucY-hiPS96YDFB_UCwMPSGAk-QTQPpYtxwWcA9iuljH_p_qjn5Z-4StpP7KH0aTx5PYffnltt2z6BbV404R_Cs2UW7L18Ltnv4 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Imidazopyridine-derivatives+as+inducible+no-synthase+inhibitors&rft.inventor=Ulrich%2C+Wolf-Ruediger&rft.number=7709488&rft.date=2010-05-04&rft.externalDBID=n%2Fa&rft.externalDocID=07709488 |