Imidazolyl derivatives
The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonist or antagonists of somatostatin receptors.
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Format | Patent |
Language | English |
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29.12.2009
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Abstract | The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonist or antagonists of somatostatin receptors. |
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AbstractList | The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonist or antagonists of somatostatin receptors. |
Author | Gordon, Thomas D Bigg, Dennis C. H Poitout, Lydie Francine Moinet, Christophe Philippe Morgan, Barry A Thurieau, Christophe Alain Galcera, Marie-Odile |
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References | Stocker, Fred B. et al.; Chem. Abstract, 1970, 72:121434. (97/30053) 19970800 Hirschmann, Ralph et al.; "De Novo Design and Synthesis of Somatostatin . . . "; Journal of the American Chemical Society; 1996, vol. 115, No. 26; pp. 12550-12568; XP002124710. (97/43278) 19971100 Thurieau et al. (6852725) 20050200 (01-203383) 19890800 (96/11927) 19960400 (99/64401) 19991200 (00/00477) 20000100 Bundgaard, Hans, Design of Prodrugs, 1985, p. 1, Elsevier Science Publishers. Hirschmann, Ralph et al.; "Nonpeptidal Peptidomimetics with a beta-D-glucose Scaffolding"; Journal of the American Chemical Society; 1992, vol. 114, No. 23; XP002124711. Morgenstern, R. et al., "Antihistamine activity of some 4-phenylimidazoles", Pharmazie, 1975, 30:103-105. (in English). Von Geldern, Thomas W. et al.; Chem Abstract, 1996, 124:193276. Carini et al. (5128355) 19920700 (98/27108) 19980600 Albert, Rainer, et al.; "Direct Synthesis of [DOTA-Dphe1]-Octreotide (SMT487): . . . "; Bioorganic & Medicinal Chemistry Letters, 1998,vol. 8; pp. 1207-1210; XP002124712. Ellinger and Goldberg; J. Chem. Soc.; 1949; 263, 266; Beilstein Registry No. 1965. (218 460) 19870900 Towliati, Hossein; Chem. Abstract, 1971, 74:53642. (95/08550) 19950300 Von Geldern et al., "Azole endothelin antagonists. 1. A receptor model explains an unusual structure-activity profile," J. Med. Chem., 1996, 394(4):957-967. (2 132 632) 19721100 Carr et al. (5733882) 19980300 Miller, William H. et al.; Chem. Abstract 1997, 127:161822. Thurieau et al. (7238695) 20070700 (WO 9964401) 19991200 Barraclough, P. et al., "Synthesis and pharmacological properties of BW315C and other inotropic 2-arylimidazo[1,2-a]pyrazines", Bioroganic & Med. Chem. Letters, 1993, 3:509-514. (94/04494) 19940300 Bornowski, Heinz et al.; Chem. Abstract 1973, 78:13689. Avallone, L. et al., "Research on heterocyclic compounds, XXXV[1]. Synthesis of 2-phenylimidazo[1,2-a]-pyrazine-3-acetates", Monatshefte fur Chemie, 1996, 127:947-953. Von Geldern, Thomas W. et al.; Chem. Abstract, 1996, 124:127005. (99/65942) 19991200 Werbel, L. M. et al., "Synthesis of fused imidazo-heterocyclic systems", J. Heterocyclic Chem., 1965, 2:287-290. Gordon, T. D. et al., "Synthetic approaches to the "azole" peptide mimetics," Tet. Lett., 34:1901-1904, 1993. Gordon, Thomas D. et al.; Chem. Abstract 1997, 127:248417. Al-Dabbagh et al., "Species differences in oxidative drug metabolism: some basic considerations," Archives of Toxicology, 1984Supplement 7:219-231. (0 166 609) 19860100 Silverman, R., The Organic Chemistry of Drug Design and Drug Action, 1992, p. 352-400, Academic Press, Inc. (97/45425) 19971200 Emery, P.T.J. et al., "Anti-secretory properties of non-peptide somatostatin receptor agonists in isolated rat colon: luminal activity and possible interaction with p-glycoprotein," Br. J. Pharm., 135:1443-1448, 2002. Spitzer, W. A. et al., "Imidazo[1,2-1]pyrimidines and imidazo[1,2-a]pyrazines: the role of nitrogen position in inotropic activity", J. Med. Chem., 1988, 31:1590-1595. Ellinger and Goldberg; J. Chem. Soc.; 1949; 263, 266; Beilstein Registry No. 3689018. Papageorgiou, Christos et al.; "A Non-peptide ligand for the Somatostatin Receptor having a Benzodiazepinone Structure"; Bioorganic & Medicinal Chemistry Letters; 1996, vol. 6, No. 3; pp. 267-272; XP004135075. (97/24119) 19970700 Von Geldern, Thomas W. et al.; Chem. Abstract, 1996, 124:164291. (96/16040) 19960500 Gramberg, Dieter et al; "Synthesis of a Type Vibeta-Turn Peptide . . . ";Helvetica Chimica Acta; 1995, vol. 78, pp. 1588-1606; XP000612160. (96/00730) 19960100 Ellinger and Goldberg; J. Chem. Soc.; 1949; 263, 266; Beilstein Registry No. 3798855. Towliati, H. "Report on the synthesis of imidazole derivatives", Chem. Reports., 1970, 103:3952-3953. (English translation). |
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