Sterile immunogenic non-tumorigenic tumor cell compositions and methods

This invention relates to methods of removing bioburden from an aggregate of cells to obtain sterile cells that remain viable and immunogenic for the production of vaccines. This invention further relates to a method of eliciting an immune response to prevent a recurrence of metastases that involves...

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Main Authors Haspel, Martin V, Pomato, Nicholas, Hanna, Jr, Michael G
Format Patent
LanguageEnglish
Published 08.12.2009
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Abstract This invention relates to methods of removing bioburden from an aggregate of cells to obtain sterile cells that remain viable and immunogenic for the production of vaccines. This invention further relates to a method of eliciting an immune response to prevent a recurrence of metastases that involves preparing and administering a sterile vaccine derived from solid tumors. The vaccine is prepared by excising a solid tumor from a cancer patient, digesting the tumor cells with an enzyme to obtain dissociated cells, irradiating the dissociated cells to render the cells non-tumorigenic, and sterilizing the cells.
AbstractList This invention relates to methods of removing bioburden from an aggregate of cells to obtain sterile cells that remain viable and immunogenic for the production of vaccines. This invention further relates to a method of eliciting an immune response to prevent a recurrence of metastases that involves preparing and administering a sterile vaccine derived from solid tumors. The vaccine is prepared by excising a solid tumor from a cancer patient, digesting the tumor cells with an enzyme to obtain dissociated cells, irradiating the dissociated cells to render the cells non-tumorigenic, and sterilizing the cells.
Author Haspel, Martin V
Hanna, Jr, Michael G
Pomato, Nicholas
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References Berd (6333028) 20011200
Margolis-Nunno et al. (6413714) 20020700
Harris, J.E., "Adjuvant Active Specific Immunotherapy for Stage II and III Colon Cancer with an Autologous Tumor Cell Vaccine: Eastern Cooperative Oncology Group Study E5283", Journal of Clinical Oncology, vol. 18, No. 1, Jan. 2000, pp. 148-157.
Hanna MG Jr, Peters LC, Hoover HC Jr., "Immunotherapy by active specific immunization: Basic Principles and Preclinical Studies", Biologic Therapy of Cancer Principles and Preclinical Studies, pp. 651-669, 1991.
Hoover HC Jr, Surdyke MG, Dangel RB, et al., "Prospectively randomized trial of adjuvant active specific immunotherapy for human colorectal cancer", Cancer 55:1236-1243, Mar. 1985.
Hanna MG Jr, Peters LC., "Specific immunotherapy of established visceral micrometastases by BCG-tumor cell vaccine alone or as an adjunct to surgery", Cancer 42:2613-2625, Dec. 1978.
Hanna MG Jr, Peters LC., "Morphological and functional aspects of active specific immunotherapy of established pulmonary metastases in guinea pigs", Cancer Res 41:4001-4009, Oct. 1981.
Smilowitz et al. (6299873) 20011000
Wood (6406699) 20020600
Peterson (5730933) 19980300
Hanna MG Jr, Zbar B, Rapp HJ., "Histopathology of tumor regression after intralesional injection of Mycobacterium bovis. I. Tumor growth and metastasis," J Natl Cancer Inst 48:1441-1455, May 1972.
Peters LC, Hanna MG Jr., "Active specific immunotherapy of established micrometastasis: Effect of cryopreservation Procedures on Tumor Cell Immunogenicity in Guinea Pigs", J Natl Cancer Inst 64:1521-1525, Jun. 1980.
Hanna MG Jr, Peters LC., "Immunotherapy of established micrometastases with bacillus calmette-guérin tumor cell vaccine", Cancer Res 38:204-209, Jan. 1978.
Granger (5837233) 19981100
Peters, L.C. et al., "Preparation of Immunotherapeutic Autologous Tumor Cell Vaccines from Solid Tumors", Cancer Research, vol. 39, Apr. 1979, pp. 1353-1360.
Hanna, Jr. et al. (5484596) 19960100
Dalmasso et al. (5788941) 19980800
Hanna MG Jr, Snodgrass MJ, Zbar B, Rapp HJ., "Histopathology of tumor regression after intralesional injection of Mycobacterium bovis. IV. Development of immunity to tumor cells and to BCG", J Natl Cancer Inst 51:1897-1908, Dec. 1973.
Holler (5532141) 19960700
Examination Report issued Jun. 26, 2007.
Ravindranath et al. (6218166) 20010400
Hanna MG Jr, Peters LC., "Efficacy of intralesional BCG therapy in guinea pigs with disseminated tumor", Cancer 36:1298-1304, Oct. 1975.
(0151030) 19850800
Granger (6136306) 20001000
Hrinda et al. (5300433) 19940400
Laugharn, Jr. et al. (6270723) 20010800
Girardot et al. (6506339) 20030100
Hanna MG Jr, Peters LC, Fidler IJ, "The efficacy of BCG-induced tumor immunity in guinea pigs with regional and systemic malignancy", Cancer Immunol Immunother 1:171-177, 1976.
Janicke et al (1994), Cancer Research, vol. 54, pp. 2527-2530.
Hoover HC Jr, Surdyke M, Dangel RB, et al., "Delayed cutaneous hypersensitivity to autologous tumor cells in colorectal cancer patients immunized with an autologous tumor cell: Bacillus Calmette-Guérin vaccine", Cancer Res 44:1671-1676, Apr. 1984.
Maes (6090385) 20000700
Hanna, M.G. Jr., "Adjuvant Active Specific Immunotherapy of Stage II and III Colon Cancer with an Autologous Tumor Cell Vaccine: First Randomized Phase III Trials Show Promise", Vaccine, vol. 19, No. 17-19, Mar. 2001, pp. 2576-2582.
Hamer et al (1999), J Bone Joint Surg [Br], 81-B, pp. 342-344.
Young et al. (6180357) 20010100
Dalgleish et al. (6699483) 20040300
Hanna MG Jr, Brandhorst JS, Peters LC., "Active specific immunotherapy of residual micrometastasis: An evaluation of sources, doses and ratios of BCG with tumor cells", Cancer Immunol Immunother 7:165-173, 1979.
Definition of "excision" in Merriam-Webster Online Dictionary downloaded on Jan. 30, 2007 from the url, world wide web, m-w.com.
Judy et al. (4878891) 19891100
(WO 93/06867) 19930400
Peters LC, Brandhorst JS, Hanna MG Jr., "Preparation of immunotherapeutic autologous tumor cell vaccines from solid tumors", Cancer Res 39:1353-1360, Apr. 1979.
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Title Sterile immunogenic non-tumorigenic tumor cell compositions and methods
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