Process for the preparation of 3-spiro′cyclohexan-1,3′-′3H!indolin-2′-one! derivatives

The invention relates to a process for the preparation of a compound of the formula (I) by reacting a compound of the formula (II) with a compound of the formula (III) characterized by dissolving the compounds of the formula (II) and formula (III) in a water-inmiscible organic solvent in the presenc...

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Main Authors Csikós, Eva, Gönczi, Csaba, Hajdú, Felix, Hermecz, István, Héja, Gergely, Héja, Gergelyné, Majláth, Csilla, Nagy, Lajos, Sántáné Csutor, Andrea, Szomor, Tiborné, Szvoboda, Györgyné
Format Patent
LanguageEnglish
Published 17.11.2009
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Summary:The invention relates to a process for the preparation of a compound of the formula (I) by reacting a compound of the formula (II) with a compound of the formula (III) characterized by dissolving the compounds of the formula (II) and formula (III) in a water-inmiscible organic solvent in the presence of a phase transfer catalyst, reacting with a.) an aqeuos solution of a base, or b.) a base in solid form directly and if desired transforming the compound of formula (I) thus obtained into its salt.