Substituted imidazoles
This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.
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Format | Patent |
Language | English |
Published |
22.09.2009
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Abstract | This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides. |
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AbstractList | This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides. |
Author | Chubb, Nathan Anthony Logan Lauret, Christelle Ewin, Richard Andrew Dauvergne, Jerome Sebastien Cox, Mark Roger |
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References | Galley et al. (2007/0197621) 20070800 (WO 2005/007188) 20050100 PCT International Search Report, PCT/IB2007/000071. Wolff et al. (Burger's Medicinal Chemistry, 5th Ed., vol. 1, pp. 975-977, 1994). Buschmann et al. (2005/0222135) 20051000 (01/94318) 20011200 (WO 99/28300) 19990600 Colombo et al. (5017596) 19910500 Huh, Dal H. A novel synthetic method for 2-arylmethyl substituted imidazolines and imidazoles from 2 aryl-1,1-dibromoethenes. Tetrahedron 60 (2004) 9857-9862. Nathanson (4678775) 19870700 Bachmann et al. (6103733) 20000800 Torregrosa et al., "Isoprene-catalyzed lithiation of imidazole: synthesis of 2-(hydroxyalkyl)- and 2-(aminoalkyl) imidazoles", Tetrahedron, 61:11148-11155, 2005. (2 681 322) 19930300 (WO 03/092374) 20031100 Nardi et al., "Research Research on durene derivatives. Note I-hypertensive activity of 2-(2,3,5,6-tetramethylbenzyl) imidazoline and related compounds", Farmaco, Ed. Sci., 34(9):789-801, 1979. Stella, Valentino J, Expert Opinion of Therapeutic Patents, Prodrugs as therapeutics, 2004 14(3): 277-280. Testa, Bernard, Biochemical Pharmacology, Prodrug Research: futile or fertile? 68 (2004) 2097-2106. Bowles (2006/0178404) 20060800 (103 04 374) 20040800 Patani, George A. Bioisosterism: A rational approach in drug design. Chem. Rev. 96 (1996) 3147-3176. Miller, Duane D. Synthesis and α2-Adrenoceptor Effects of Substituted Catecholimidazoline and Catecholimidazole Analogues in Human Platelets. Journal of Medicinal Chemistry. 33 (1990) 1138-1144. Allegretti et al. (2007/0155717) 20070700 (7-243054) 19950900 (WO 2004/103959) 20041200 Chubb et al. (2007/0167506) 20070700 Spada et al. (5646153) 19970700 (WO 01/00686) 20010100 Ettmayer, Peter, Medicinal Chemistry, Lessons Learned from Marketed and Investigational Prodrugs, 47(10) (2004) 2394-2404. |
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Snippet | This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to... |
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